DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10321 and zbtb20

DIOPT Version :9

Sequence 1:	NP_001261124.1	Gene:	CG10321 / 37464	FlyBaseID:	FBgn0034643	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_021331970.1	Gene:	zbtb20 / 568779	ZFINID:	ZDB-GENE-070112-1992	Length:	707	Species:	Danio rerio

Alignment Length:	707	Identity:	145/707 - (20%)
Similarity:	234/707 - (33%)	Gaps:	232/707 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 QLITTAQIVAPQLAQIISTAPQSTTNGQATAAQSQFLPQLLQTPNGQTLQIVQQPNGTQTLQLVQ 295
            |::|.|.|:  |:..:|....:..:.....:....|             .:|...:|.:|
Zfish   119 QILTAASIL--QIKTVIDECTRIVSQNVGISGSGSF-------------SVVPGDSGQET----- 163

  Fly   296 LVPQRSLAPTGVTTVTTTTNATDMGQHVGASLGDADVQLLEDGCEVEDEELEDVYEQLDSKADHS 360
                    |.|.....|:..::|                      .|...::..::.:.|....|
Zfish   164 --------PRGTPESGTSGPSSD----------------------AESGYMQTSHQSVYSSLYSS 198

  Fly   361 FETIVLDDDQQQDFLKDHHEHHQVMINED----LTQSES-QD-------HEYFDDLDQQQAMDEI 413
            ...:.|.:..:.:  :.|:....|:.|.|    |.|.|: ||       ||....:::..:..|.
Zfish   199 CSGLGLQNGTRGN--RSHYAGAAVIANYDSALPLQQKEAGQDPAWITRIHERSQQMERFLSTTET 261

  Fly   414 EDEEEQMKP-----------EEDQDTFI---IEEIQLEDDEMLD----DPDGEEIDQD-CEYIGE 459
            ....:|.:|           :|..|.|.   ||:.: ||.|.|:    :|.||..|.. ...||.
Zfish   262 THCRKQPRPVRLHPGDIHIKQEQGDEFNCYGIEDCR-EDGEPLECVESEPKGESFDSGVSSSIGT 325

  Fly   460 EQD----PHLSGDVDDDLEYSIMEPPDGE-----TSVDIDQAFMDSEQSHHQQHQEEMQSISLEN 515
            |.|    |.|||         ...|..|:     |.|.|     :...|..:|.||
Zfish   326 ETDSVEQPFLSG---------FNCPSKGQQGERGTPVQI-----EVNDSSPEQTQE--------- 367

  Fly   516 AVVEFSQATTTTEALVGPTMTVSSASPTPKRAKRSNHQ--------IPAGVTLEPCDHQPPAAGS 572
             ::|.|                |...||.:..:...||        :|.|..|.|.:   |.. |
Zfish   368 -IIEDS----------------SGNGPTQESGEIGIHQANLTAPQVMPGGPYLRPGE---PLT-S 411

  Fly   573 TTSSKLAAANSRQLVQTA------SVIAAAGADDN----YEIDANLVT---EFI----------- 613
            .....|...::.|::.||      ::.|...|.||    :.:..::.:   :|:
Zfish   412 NLRMPLTLTSNSQVMGTAGNTYLPTLFATQSASDNKPFLFSLPQSIGSQQPQFVAVPSPNMPPFP 476

  Fly   614 -----------RQHTSPLGS-GR---YICHLCSTEFRQFKGLQNHMHSHTNWIRANCKKQPQCQI 663
                       :|..:|.|. |.   |.|.||...|...:....||..||.      :|..||.|
Zfish   477 GGLSVPPGGSQQQGGAPGGQHGEKKPYACTLCCKTFTAKQNYVKHMFVHTG------EKPHQCSI 535

  Fly   664 CLKSFKGPGMLRMHMKTHDAESSTPMCTICNRTFKSKAILYRHRQTHQ-QRAYCCGVANCRKNFS 727
            |.:||.....|..||.||....:. .|:|||:.|..|:.|..|.:.|: :::|.|.:  |:|.||
Zfish   536 CWRSFSLKDYLIKHMVTHTGVRAY-QCSICNKRFTQKSSLNVHMRLHRGEKSYECYI--CKKKFS 597

  Fly   728 SAVNLKWHVERKHPEVVDPLFKCGECGSLYDNVDSLQLHVESTDHSAEVQISGQDDAFSGA---- 788
            ....|:.|                           :.||...:..|....:||...|...|
Zfish   598 HKTLLERH---------------------------MALHSTGSGVSGVSGVSGAGSAGGPASIPV 635

  Fly   789 -VSIVSNGTTDMSNMMATGQGTTLAGGTGDTHAVVMGSS----GEVYFVTQAXPAEF 840
             :::...|...::..|..|.|.. .||.|:....|...:    |..| :....|.:|
Zfish   636 PMAVPEPGAGVVALAMPVGGGVA-GGGVGNAGVGVAAEASCQEGTTY-MCSVCPVKF 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10321	NP_001261124.1	zf-AD	12..80	CDD:214871
		ASF1_hist_chap	<405..516	CDD:304562	33/138 (24%)
		C2H2 Zn finger	627..647	CDD:275368	6/19 (32%)
		C2H2 Zn finger	661..681	CDD:275368	8/19 (42%)
		C2H2 Zn finger	690..710	CDD:275368	8/19 (42%)
		C2H2 Zn finger	717..740	CDD:275368	7/22 (32%)
		C2H2 Zn finger	750..767	CDD:275368	1/16 (6%)
zbtb20	XP_021331970.1	BTB	41..143	CDD:306997	6/25 (24%)
		C2H2 Zn finger	505..525	CDD:275368	6/19 (32%)
		zf-C2H2	531..553	CDD:306579	9/21 (43%)
		C2H2 Zn finger	533..553	CDD:275368	8/19 (42%)
		zf-H2C2_2	545..570	CDD:316026	10/25 (40%)
		zf-C2H2	559..581	CDD:306579	8/22 (36%)
		C2H2 Zn finger	561..581	CDD:275368	8/19 (42%)
		zf-H2C2_2	573..598	CDD:316026	8/26 (31%)
		C2H2 Zn finger	589..609	CDD:275368	7/48 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24399
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100