DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10321 and zbtb33

DIOPT Version :9

Sequence 1:	NP_001261124.1	Gene:	CG10321 / 37464	FlyBaseID:	FBgn0034643	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_001093478.1	Gene:	zbtb33 / 562507	ZFINID:	ZDB-GENE-070412-3	Length:	624	Species:	Danio rerio

Alignment Length:	462	Identity:	95/462 - (20%)
Similarity:	164/462 - (35%)	Gaps:	113/462 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   422 PEEDQD-----TFIIEEIQLEDDEM-LDDPDGEEIDQDCE---YIGEEQDPHLSGDVDDDLEYSI 477
            ||:.:|     ..|.|...|..:|. :...:.|:.|.|.:   ::.:.:.|........|:..:|
Zfish   141 PEKPEDGGVNMPIITETFSLSAEEFNMTGANTEKEDSDSDDVLFVSKTEAPQAQKTKISDVHKNI 205

  Fly   478 MEPPDGETSVDIDQAFMDSEQSHHQQHQEEMQSISLEN----AVVEFSQATTTTEALVGPTMTVS 538
            ...|:.:.....::..:..:.|..|:.:...::.||:|    .||..|....::..|..|..|.|
Zfish   206 EGAPETKKQKVTNEEGVAPKSSIPQEKKSSERNASLQNNLDPDVVILSSPEKSSSILTSPVGTGS 270

  Fly   539 SASPTPKRAKRSNHQIPAGVTLEPCD---------------HQPPAAGSTTSSKLAAANS----- 583
            :::|.|.....|....|..|:| |.|               |.|...|..|.|.:.::.|
Zfish   271 NSNPKPPACPDSVPSDPQNVSL-PSDNIEVLGVQKKKVLLEHSPDHPGKITLSDVRSSCSSSNGP 334

  Fly   584 RQLVQTASVIAAAGADDNYEID---------ANL---VTEFIRQHTSPLGSGRYICHLCSTEF-- 634
            ..::...||......|...|||         ||:   ..:.:.....|   |......|.::.
Zfish   335 TNVIPALSVKKTITLDKASEIDSLSPGCKVYANIGENTYDIVPVKDDP---GEGAAPGCKSQIQP 396

  Fly   635 -------------RQFK-GLQNH----MHSHTNWIRANCKKQPQCQICLKSFKGPGMLRMHMKTH 681
                         ::|| ..::|    |...|.::...||:.   .:||.|      ||.|..||
Zfish   397 DSPNTASLSPKSKKKFKPDQEDHYEIIMDGKTFFVCIVCKRP---YVCLTS------LRRHFNTH 452

  Fly   682 DAESSTPMCTICNRTFKSKAILYRHRQTHQ-QRAYCCGVANCRKNFSSAVNLKWHVERKHPEVVD 745
            ..|...| |..||:.|.......:|..:|. :|.|.|.:  |.:.|.:...|..|.::.|.:  |
Zfish   453 SWERKYP-CHYCNKVFALAEYRTKHEISHTGERRYQCLL--CNEMFLNYQILSTHCKQAHNQ--D 512

  Fly   746 P------------LFKCGECGSL----YDNVDSLQLHVESTDHSAEVQISGQDDAFSGAVSIVSN 794
            |            |::...|.::    |..|         :|.|....:.|:|    |.:..|::
Zfish   513 PSGRKEKDDSANNLYRLLPCKTVQFKPYSFV---------SDESGGSPVIGED----GTIQYVNS 564

  Fly   795 GTTDMSN 801
            .....:|
Zfish   565 EKEHCTN 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10321	NP_001261124.1	zf-AD	12..80	CDD:214871
		ASF1_hist_chap	<405..516	CDD:304562	19/106 (18%)
		C2H2 Zn finger	627..647	CDD:275368	5/39 (13%)
		C2H2 Zn finger	661..681	CDD:275368	6/19 (32%)
		C2H2 Zn finger	690..710	CDD:275368	5/19 (26%)
		C2H2 Zn finger	717..740	CDD:275368	5/22 (23%)
		C2H2 Zn finger	750..767	CDD:275368	3/20 (15%)
zbtb33	NP_001093478.1	BTB	23..116	CDD:279045
		BTB	33..116	CDD:197585
		C2H2 Zn finger	432..452	CDD:275368	8/28 (29%)
		zf-H2C2_2	444..468	CDD:290200	11/30 (37%)
		C2H2 Zn finger	460..480	CDD:275368	5/19 (26%)
		C2H2 Zn finger	488..504	CDD:275368	4/17 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24399
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100