DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10321 and zbtb24

DIOPT Version :9

Sequence 1:	NP_001261124.1	Gene:	CG10321 / 37464	FlyBaseID:	FBgn0034643	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_001018866.2	Gene:	zbtb24 / 553955	ZFINID:	ZDB-GENE-081022-123	Length:	678	Species:	Danio rerio

Alignment Length:	615	Identity:	129/615 - (20%)
Similarity:	194/615 - (31%)	Gaps:	234/615 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   343 DEELEDVYEQLDSKADHSFET--------IVLDDDQQQ-------------DFLKDHH------E 380
            :|::.....:||....::|.:        :||.|:...             |.:|.|.      |
Zfish    74 EEQVSQSLYKLDGMTANTFSSVLEFMYSAVVLVDESSSEQLMEMARFLVIPDLIKAHEDLQAVDE 138

  Fly   381 HHQV-------MINEDLTQSESQDHEYFDDLDQQQAMDEIED-EEEQMKPEEDQDTFIIEEIQLE 437
            |.||       ..|:||:|.|:.:.|.     |.|:..||:: .||...|
Zfish   139 HMQVKRKRGRPKKNQDLSQKENPESEL-----QAQSSSEIQEVNEEPASP--------------- 183

  Fly   438 DDEMLDDPDGE-------------EIDQDCEYIGEEQDPHLSGDVDDDLEYSIMEP--------- 480
               ..|..|||             :|.|.....|...|..:.|          .||
Zfish   184 ---ATDGSDGEFNPREERRREGKRKIKQPIRLKGFRMDDLMEG----------KEPGKRGRRRKY 235

  Fly   481 PDGETSVDIDQAFMDSEQSHHQQHQEEMQSISLENAVVEFSQATTTTEALVGP-TMTVSSASPTP 544
            ||.|...                  ||...:...:..::..|.|.|.|.   | ..:|.....|.
Zfish   236 PDTEARC------------------EECGKVFKSHLFLKIHQRTHTGEK---PFRCSVCGKEFTQ 279

  Fly   545 KRAKRSNHQIPAGVTLEPCDHQPPAAGSTTSSKLAAANSRQLVQTASVIAAAGADDNYEIDANLV 609
            |.....:.::..|        :.|...:..|..|:..:|                         :
Zfish   280 KHTLLVHQRMHTG--------EKPYICTVCSKALSTKHS-------------------------L 311

  Fly   610 TEFIRQHTSPLGSGRYICHLCSTEFRQFKGLQNHMHSHTNWIRANCKKQPQCQICLKSFKGPGML 674
            .|.:..||.   :..:.|..|...|.|.:.|::|...||.      |..|:|..|...|.....|
Zfish   312 LEHMNLHTE---NKLFTCEECGKSFSQQRQLKSHNRVHTG------KGLPECAECHHKFMDAAQL 367

  Fly   675 RMHMKTHDAESSTPM-CTICNRTFKSKAILYRHRQTHQ-QRAYCCGVANCRKNFSSAVNLKWHVE 737
            :.|::||..|.  |. |.||.:.|.:|:.|..|.:.|: ::.|.|.|  |.|.||..     ...
Zfish   368 KKHLRTHTGEK--PFTCEICGKCFTAKSTLQTHIRIHRGEKPYVCKV--CDKTFSDP-----SAR 423

  Fly   738 RKHPEVV---DPLFKCGECGSLYDNVDSLQLHV------------ESTD---HSA---------- 774
            |:| ||.   ...|.|..|...:...|:|:.|:            ||||   |||
Zfish   424 RRH-EVSHTGKKTFSCSICKVSFARKDNLKAHIKTHNKENPPAQAESTDKPPHSAPEQQQQQQEQ 487

  Fly   775 ---EVQISGQDDAFS-------------------------------GAVSIVSNGTTDMSNMMAT 805
               :.|.||..:..|                               .::||:::..|:.|..:.|
Zfish   488 EQQQQQTSGDKELHSILQLQPFQLPAHGEQEIQLLVTGENLSLDQEQSISIITSEDTEQSLALLT 552

  Fly   806 ---GQGTTLAGGTGDTHAVVMGSS---GEV 829
               |....||..|.|.:|.:...|   |||
Zfish   553 QPSGHVQNLAVVTPDGNAQIQTISVLGGEV 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10321	NP_001261124.1	zf-AD	12..80	CDD:214871
		ASF1_hist_chap	<405..516	CDD:304562	23/133 (17%)
		C2H2 Zn finger	627..647	CDD:275368	6/19 (32%)
		C2H2 Zn finger	661..681	CDD:275368	5/19 (26%)
		C2H2 Zn finger	690..710	CDD:275368	7/19 (37%)
		C2H2 Zn finger	717..740	CDD:275368	7/22 (32%)
		C2H2 Zn finger	750..767	CDD:275368	4/16 (25%)
zbtb24	NP_001018866.2	BTB	32..129	CDD:279045	8/54 (15%)
		BTB	43..129	CDD:197585	8/54 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..211		22/94 (23%)
		C2H2 Zn finger	242..262	CDD:275368	3/37 (8%)
		zf-H2C2_2	255..279	CDD:290200	6/26 (23%)
		COG5048	<266..456	CDD:227381	56/244 (23%)
		C2H2 Zn finger	270..290	CDD:275368	3/19 (16%)
		zf-H2C2_2	283..307	CDD:290200	4/31 (13%)
		C2H2 Zn finger	298..318	CDD:275368	4/44 (9%)
		zf-H2C2_2	310..335	CDD:290200	7/52 (13%)
		zf-C2H2	324..346	CDD:278523	6/21 (29%)
		C2H2 Zn finger	326..346	CDD:275368	6/19 (32%)
		C2H2 Zn finger	354..374	CDD:275368	5/19 (26%)
		zf-H2C2_2	367..390	CDD:290200	9/24 (38%)
		C2H2 Zn finger	382..402	CDD:275368	7/19 (37%)
		zf-H2C2_2	395..418	CDD:290200	8/24 (33%)
		C2H2 Zn finger	410..430	CDD:275368	10/27 (37%)
		zf-C2H2	436..458	CDD:278523	6/21 (29%)
		C2H2 Zn finger	438..458	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24399
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100