DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10321 and Zbtb37

DIOPT Version :9

Sequence 1:	NP_001261124.1	Gene:	CG10321 / 37464	FlyBaseID:	FBgn0034643	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_001100661.1	Gene:	Zbtb37 / 304918	RGDID:	1308731	Length:	504	Species:	Rattus norvegicus

Alignment Length:	452	Identity:	94/452 - (20%)
Similarity:	153/452 - (33%)	Gaps:	127/452 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   380 EHHQVMINEDLTQSESQDHEYFDDLDQQQAMDEIEDEEEQMKPEEDQDTFIIEEIQLEDDEMLDD 444
            |.|:|..|  ||:|.|..|..... :.:..:..:.|..|...|||.....|||:        ..|
  Rat   153 ESHRVTPN--LTRSLSPRHNASKG-NWRGQVSAVLDIRELSPPEESTSPQIIEQ--------SSD 206

  Fly   445 PDGEE----IDQDCEYIGE----EQDPHLSGD----------VDDDLEYSI--MEPPDGETSVDI 489
            .:|.|    |::..::..|    :|.|. |||          ..::||..:  ...|.||.....
  Rat   207 VEGREPILRINRAGQWYVETGIADQGPQ-SGDEVRVLGAVHIKTENLEEWLGPENQPSGEDGSSA 270

  Fly   490 DQ-AFMDSEQSHHQQHQEEMQSISLENAVVEFSQATTTTEALVGPTMTVSSASPTPKRAKRSNHQ 553
            :: |.|..:.:.|....:|..::....|.|                     |.||.....|.:
  Rat   271 EEVAAMVIDTTGHGSVGQESYTLGSSGAKV---------------------ARPTSSEVDRFS-- 312

  Fly   554 IPAGVTLEPCDHQPPAAGSTTSSKLAAANSRQLVQTASVIAAAGADDNYEIDANLVTEFIRQHTS 618
             |:|..:           |.|....|.:.|           ....|:..::.:.:      :.::
  Rat   313 -PSGSVV-----------SMTERHRARSES-----------PGRMDEPKQLSSQV------EESA 348

  Fly   619 PLGSGRYICHLCSTEFRQFKGLQNHMHSHTNWIRANCKKQPQ--CQICLKSFKGPGMLRMHMKTH 681
            .:|...|:.:|...|..:            .|.|.|    |:  |..|.|||...|.|..||:.|
  Rat   349 MMGVSAYVEYLREQEVSE------------RWFRYN----PRLTCIYCAKSFNQKGSLDRHMRLH 397

  Fly   682 DAESSTP-MCTICNRTFKSKAILYRHRQTHQ-QRAYCCGVANCRKNFSSAVNLKWHVERKHPEVV 744
              ...|| :|.:|.:.:..|..|..|.:.|. .:.:.|.|  |.|:|.....|..|..:.||..:
  Rat   398 --MGITPFVCRMCGKKYTRKDQLEYHIRKHTGNKPFHCHV--CGKSFPFQAILNQHFRKNHPGCI 458

  Fly   745 DPLFKCGECGSLYDNVDSLQLHVESTDHSAEVQISGQDDAFSGAVSIVSNGTTDMSNMMATG 806
             ||          :...|:......|...||......::.       |:.|.:...::..||
  Rat   459 -PL----------EGPHSISPETTVTSRQAEEGSPSHEET-------VAPGESAQGSVSTTG 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10321	NP_001261124.1	zf-AD	12..80	CDD:214871
		ASF1_hist_chap	<405..516	CDD:304562	27/131 (21%)
		C2H2 Zn finger	627..647	CDD:275368	2/19 (11%)
		C2H2 Zn finger	661..681	CDD:275368	9/19 (47%)
		C2H2 Zn finger	690..710	CDD:275368	5/19 (26%)
		C2H2 Zn finger	717..740	CDD:275368	7/22 (32%)
		C2H2 Zn finger	750..767	CDD:275368	1/16 (6%)
Zbtb37	NP_001100661.1	BTB_POZ_ZBTB37	9..131	CDD:349531
		C2H2 Zn finger	377..397	CDD:275368	9/19 (47%)
		zf-H2C2_2	389..414	CDD:404364	8/26 (31%)
		zf-C2H2	403..425	CDD:395048	5/21 (24%)
		C2H2 Zn finger	405..425	CDD:275368	5/19 (26%)
		zf-H2C2_2	418..440	CDD:404364	7/23 (30%)
		DUF4764	<429..>497	CDD:406387	17/87 (20%)
		C2H2 Zn finger	433..451	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24399
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100