DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10321 and Zbtb24

DIOPT Version :9

Sequence 1:	NP_001261124.1	Gene:	CG10321 / 37464	FlyBaseID:	FBgn0034643	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_700447.2	Gene:	Zbtb24 / 268294	MGIID:	3039618	Length:	710	Species:	Mus musculus

Alignment Length:	488	Identity:	101/488 - (20%)
Similarity:	175/488 - (35%)	Gaps:	118/488 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   383 QVMINEDLTQSESQDHEYFDDLDQQQAMDEIEDEEEQMKPEEDQDTFIIEEIQLEDDEMLDDP-- 445
            |:.:|..:   :::.:..|.:.|..: :.|...|:::.:|..:..:  :||:..|.||..|..
Mouse   185 QLRVNNSV---QNRQNFVFKEEDSVK-LSEQTPEDKESEPAGEPGS--VEEVPAEKDENFDPKAG 243

  Fly   446 DGEEIDQDC-----EYIGEEQDPHLSGDVDDDLEYSIM-------EPPDGETSVDIDQAFMDSEQ 498
            ||:|....|     ....:.:|..|.||.||......:       ..|:.... |.|:.|   :.
Mouse   244 DGQESQSRCSRRRIRRSVKLKDYKLLGDEDDQSTAKRLCGRKKRSSGPEARCK-DCDRVF---KY 304

  Fly   499 SH----HQQHQEEMQSISLENAVVEFSQATTTTEALVGPTMTVSSASPTPKRAKRSNHQIPAGVT 559
            ||    ||:.....:..........|:|                      |.:.:.:.::..|..
Mouse   305 SHFLAIHQRRHTGERPFKCNECGKGFAQ----------------------KHSLQVHTRMHTGER 347

  Fly   560 LEPCDHQPPAAGSTTSSKLAAANSRQLVQTASVIAAAGADDNYEIDANLVTEFIRQHTSPLGSGR 624
            ...|    ...|...::|                             :.:.|.:..|:   |...
Mouse   348 PYTC----TVCGKALTTK-----------------------------HSLLEHMSLHS---GQKS 376

  Fly   625 YICHLCSTEFRQFKGLQNHMHSHTNWIRANCKKQPQCQICLKSFKGPGMLRMHMKTHDAESSTPM 689
            :.|..|...|.|.:.|::|...||.      ...|:|..|.:.|.....|:.|::||..|.  |.
Mouse   377 FTCDQCGKYFSQKRQLKSHYRVHTG------HSLPECSHCHRKFMDVSQLKKHLRTHTGEK--PF 433

  Fly   690 -CTICNRTFKSKAILYRHRQTHQ-QRAYCCGVANCRKNFSSAVNLKWHV---ERKHPEVVDPLFK 749
             |.||.::|.:|:.|..|.:.|: ::.|.|.:  |.|.||.:...:.|.   ..|.|      |.
Mouse   434 TCEICGKSFTAKSSLQTHIRIHRGEKPYSCSI--CGKCFSDSSAKRRHCILHTGKKP------FS 490

  Fly   750 CGECGSLYDNVDSLQLHVESTDHSAEVQISGQDDAFSGAVSIVSNGTTDMS----NMMATGQGTT 810
            |.|||..:..:|:|:.|::.  ||.|...:   |:.|.:.|.|..|...:.    .:..:|:...
Mouse   491 CPECGLQFARLDNLKAHLKI--HSKEKHTA---DSSSVSGSNVDEGRNILQLQPYQLSTSGEQEI 550

  Fly   811 LAGGTGDTHAV--VMGSSGEVYFVTQAXPAEFA 841
            ....|...|.:  :.|.|..|..|... |...|
Mouse   551 QLLVTDSVHNINFMPGPSQGVSIVAAESPQSMA 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10321	NP_001261124.1	zf-AD	12..80	CDD:214871
		ASF1_hist_chap	<405..516	CDD:304562	28/128 (22%)
		C2H2 Zn finger	627..647	CDD:275368	6/19 (32%)
		C2H2 Zn finger	661..681	CDD:275368	5/19 (26%)
		C2H2 Zn finger	690..710	CDD:275368	7/19 (37%)
		C2H2 Zn finger	717..740	CDD:275368	6/25 (24%)
		C2H2 Zn finger	750..767	CDD:275368	6/16 (38%)
Zbtb24	NP_700447.2	BTB	27..128	CDD:279045
		BTB	38..133	CDD:197585
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	134..176
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..256		14/56 (25%)
		C2H2 Zn finger	295..315	CDD:275368	7/23 (30%)
		zf-H2C2_2	308..332	CDD:290200	3/23 (13%)
		COG5048	<320..479	CDD:227381	42/226 (19%)
		C2H2 Zn finger	323..343	CDD:275368	3/41 (7%)
		zf-H2C2_2	335..360	CDD:290200	3/28 (11%)
		C2H2 Zn finger	351..371	CDD:275368	4/52 (8%)
		zf-H2C2_2	363..388	CDD:290200	6/27 (22%)
		C2H2 Zn finger	379..399	CDD:275368	6/19 (32%)
		COG5048	406..>563	CDD:227381	45/171 (26%)
		C2H2 Zn finger	407..427	CDD:275368	5/19 (26%)
		zf-H2C2_2	420..443	CDD:290200	9/24 (38%)
		C2H2 Zn finger	435..455	CDD:275368	7/19 (37%)
		zf-H2C2_2	447..471	CDD:290200	7/25 (28%)
		C2H2 Zn finger	463..479	CDD:275368	5/17 (29%)
		zf-H2C2_2	477..500	CDD:290200	8/28 (29%)
		C2H2 Zn finger	491..511	CDD:275368	7/21 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	651..676
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24399
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100