DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10321 and ZBTB12

DIOPT Version :9

Sequence 1:	NP_001261124.1	Gene:	CG10321 / 37464	FlyBaseID:	FBgn0034643	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_862825.1	Gene:	ZBTB12 / 221527	HGNCID:	19066	Length:	459	Species:	Homo sapiens

Alignment Length:	312	Identity:	67/312 - (21%)
Similarity:	109/312 - (34%)	Gaps:	80/312 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   450 IDQDCEYIGEEQDPHLSGDVDD----DLEYSI-----MEPPDG-ETSVDIDQAFMDSEQSHHQQH 504
            :|:|.|...||:|.....||.|    .:|.::     ::||.| ...:.|..
Human   186 LDEDLELKAEEEDEDEDEDVSDICIVKVESALEVAHRLKPPGGLGGGLGIGG------------- 237

  Fly   505 QEEMQSISLENAVVEFSQATTTTEALVGPTMTVSSASPTPKRAKRSNHQIPAGVTLEPCDHQPPA 569
                   |:...:.|.:|::.....:..|...|.:.....:.|:..      |:.|.|...  .:
Human   238 -------SVGGHLGELAQSSVPPSTVAPPQGVVKACYSLSEDAEGE------GLLLIPGGR--AS 287

  Fly   570 AGSTTSSKLAAANSRQLVQTASV-IAAAGADDNYEIDANLVTEFIRQHTSPLGSG--------RY 625
            .|:|:.          ||:.|:| :||.||..:.....:         ..||..|        ..
Human   288 VGATSG----------LVEAAAVAMAARGAGGSLGAGGS---------RGPLPGGFSGGNPLKNI 333

  Fly   626 ICHLCSTEFRQFKGLQNHMHS-HTNWIRANCKKQPQCQICLKSFKGPGMLRMHMKTHDAESSTPM 689
            .|..|...|:..:.|..||.: |..::         |..|.|.|.....|..||..|....| ..
Human   334 KCTKCPEVFQGVEKLVFHMRAQHFIFM---------CPRCGKQFNHSSNLNRHMNVHRGVKS-HS 388

  Fly   690 CTICNRTFKSKAILYRHRQTHQ-QRAYCCGVANCRKNFSSAVNLKWHVERKH 740
            |.||.:.|..|:.|:.|...|. .|.|.|  :.|...|:....::.|::.:|
Human   389 CGICGKCFTQKSTLHDHLNLHSGARPYRC--SYCDVRFAHKPAIRRHLKEQH 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10321	NP_001261124.1	zf-AD	12..80	CDD:214871
		ASF1_hist_chap	<405..516	CDD:304562	15/75 (20%)
		C2H2 Zn finger	627..647	CDD:275368	6/20 (30%)
		C2H2 Zn finger	661..681	CDD:275368	7/19 (37%)
		C2H2 Zn finger	690..710	CDD:275368	7/19 (37%)
		C2H2 Zn finger	717..740	CDD:275368	4/22 (18%)
		C2H2 Zn finger	750..767	CDD:275368
ZBTB12	NP_862825.1	BTB	23..127	CDD:306997
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..179
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		zf-C2H2	359..381	CDD:306579	7/30 (23%)
		COG5048	<361..>448	CDD:227381	24/81 (30%)
		C2H2 Zn finger	361..381	CDD:275368	7/19 (37%)
		C2H2 Zn finger	389..409	CDD:275368	7/19 (37%)
		C2H2 Zn finger	417..435	CDD:275368	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24399
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100