DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10321 and ZBTB49

DIOPT Version :9

Sequence 1:	NP_001261124.1	Gene:	CG10321 / 37464	FlyBaseID:	FBgn0034643	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_001317554.1	Gene:	ZBTB49 / 166793	HGNCID:	19883	Length:	765	Species:	Homo sapiens

Alignment Length:	438	Identity:	100/438 - (22%)
Similarity:	159/438 - (36%)	Gaps:	116/438 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   459 EEQDPHLSGDVD-----DDLEYSIMEPPDGE-TSVDIDQA--FMDSEQSHHQQHQEEMQSISLEN 515
            :|..||.|..|:     .::.....:..||. |.:...|.  :......:.:|:.:.....|.|.
Human   171 DESHPHASPSVNRHHSAGEISKQAPDTSDGSCTELPFKQPNYYYKLRNFYSKQYHKHAAGPSQER 235

  Fly   516 AVVE---FSQAT--TTTEA-----------LVGP--------TMTVSSASPTPK----------- 545
            .|.:   ||.:|  ||.|:           |..|        ...|:.::|.|:
Human   236 VVEQPFAFSTSTDLTTVESQPCAVSHSECILESPEHLPSNFLAQPVNDSAPHPESDATCQQPVKQ 300

  Fly   546 -RAKRSNH---------QIPAGVTLEP-----CDHQPPAAGSTTSSKLAAANSRQLVQTASVIAA 595
             |.|::.|         |..|....||     ...:..:|...|..| |::.|.:..::..|::.
Human   301 MRLKKAIHLKKLNFLKSQKYAEQVSEPKSDDGLTKRLESASKNTLEK-ASSQSAEEKESEEVVSC 364

  Fly   596 AGADDNYEIDANLVTE--------FIRQHTSPLGSGR-YICHLCSTEFRQFKGLQNHMHSHTNWI 651
                :|:    |.::|        .:...:..|.|.| |.|.||...|:....|:.|..|||.
Human   365 ----ENF----NCISETERPEDPAALEDQSQTLQSQRQYACELCGKPFKHPSNLELHKRSHTG-- 419

  Fly   652 RANCKKQPQCQICLKSFKGPGMLRMHMKTHDAESSTPMCTICNRTFKSKAILYRHRQTHQ-QRAY 715
                :|..:|.||.|.|...|.|:.|::.|..|... :|.||.:.|.:...:.||...|. ::.:
Human   420 ----EKPFECNICGKHFSQAGNLQTHLRRHSGEKPY-ICEICGKRFAASGDVQRHIIIHSGEKPH 479

  Fly   716 CCGVANCRKNFSSAVNLKWHVERKHPEVVDPLFKCGECGSLYDNVDSLQLHVESTDHSAEVQISG 780
            .|.:  |.:.||:..|||   |.|.....|.:|.|.|||..::....|..|  ...|:.|...|
Human   480 LCDI--CGRGFSNFSNLK---EHKKTHTADKVFTCDECGKSFNMQRKLVKH--RIRHTGERPYS- 536

  Fly   781 QDDAFSGAVSIVSNGTTDMSNMMATGQGTTLAGGTGDTHAVVMGSSGE 828
                                 ..|.|:   ..||:||....|...:||
Human   537 ---------------------CSACGK---CFGGSGDLRRHVRTHTGE 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10321	NP_001261124.1	zf-AD	12..80	CDD:214871
		ASF1_hist_chap	<405..516	CDD:304562	12/64 (19%)
		C2H2 Zn finger	627..647	CDD:275368	6/19 (32%)
		C2H2 Zn finger	661..681	CDD:275368	8/19 (42%)
		C2H2 Zn finger	690..710	CDD:275368	6/19 (32%)
		C2H2 Zn finger	717..740	CDD:275368	8/22 (36%)
		C2H2 Zn finger	750..767	CDD:275368	5/16 (31%)
ZBTB49	NP_001317554.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..203		7/31 (23%)
ZBTB49	NP_001317554.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	275..294		3/18 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24399
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100