DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10321 and ZBTB6

DIOPT Version :9

Sequence 1:	NP_001261124.1	Gene:	CG10321 / 37464	FlyBaseID:	FBgn0034643	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_006617.1	Gene:	ZBTB6 / 10773	HGNCID:	16764	Length:	424	Species:	Homo sapiens

Alignment Length:	354	Identity:	83/354 - (23%)
Similarity:	132/354 - (37%)	Gaps:	108/354 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   375 LKDHHEHHQVMINEDLTQSESQDHEYFDDLDQQQAMDEIEDEEEQMKPEEDQDTFIIEEIQLEDD 439
            :|::::|      .||.||...|               :::|:|    ..|:|..|||   :.:|
Human   133 MKNNNQH------TDLCQSSDPD---------------VKNEDE----NSDKDCEIIE---ISED 169

  Fly   440 EMLDDPDGEEIDQDCEYIGEEQDPHLSGDVDD-DLEYSIMEPPDGETSVDIDQAFMDSEQSHHQQ 503
            ..::      ||   .::.||:...|...|:. ..|...|:.|:..|   :|..|.|:|..  ..
Human   170 SPVN------ID---FHVKEEESNALQSTVESLTSERKEMKSPELST---VDIGFKDNEIC--IL 220

  Fly   504 HQEEMQSISLENAVVEFSQATTTTEALVGPTMTVSSASPTPKRAKRSNHQIPAGVTLEPCDHQPP 568
            |.|.:.:..:||.  :|||..|:::|    :|..|          .:.|.:
Human   221 HVESISTAGVENG--QFSQPCTSSKA----SMYFS----------ETQHSL-------------- 255

  Fly   569 AAGSTTSSKLAAANSRQLVQTASVIAAAGADDNY----EIDANLVTEFIRQHTSP------LGSG 623
             ..||..|::|.....|    ...:.....:.:|    ||. ||...:..:|..|      |...
Human   256 -INSTVESRVAEVPGNQ----DQGLFCENTEGSYGTVSEIQ-NLEEGYSLRHQCPRCPRGFLHVE 314

  Fly   624 RYICHL----------CSTEFRQFKGLQNHMHSHTNWIRANCKKQP-QCQICLKSFKGPGMLRMH 677
            .|:.||          |...|.|.|.|..|:..|.. ||      | ||.:|||:|.....|:.|
Human   315 NYLRHLKMHKLFLCLQCGKTFTQKKNLNRHIRGHMG-IR------PFQCTVCLKTFTAKSTLQDH 372

  Fly   678 MKTHDAESSTPMCTICNRTFKSKAILYRH 706
            :..|..:... .|..|:..||.|:.|.:|
Human   373 LNIHSGDRPY-KCHCCDMDFKHKSALKKH 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10321	NP_001261124.1	zf-AD	12..80	CDD:214871
		ASF1_hist_chap	<405..516	CDD:304562	25/111 (23%)
		C2H2 Zn finger	627..647	CDD:275368	8/29 (28%)
		C2H2 Zn finger	661..681	CDD:275368	7/19 (37%)
		C2H2 Zn finger	690..710	CDD:275368	7/17 (41%)
		C2H2 Zn finger	717..740	CDD:275368
		C2H2 Zn finger	750..767	CDD:275368
ZBTB6	NP_006617.1	BTB_POZ_ZBTB6	8..123	CDD:349506
		C2H2 Zn finger	303..323	CDD:275368	5/19 (26%)
		zf-C2H2	326..348	CDD:395048	6/21 (29%)
		C2H2 Zn finger	328..348	CDD:275368	6/19 (32%)
		zf-C2H2_8	331..401	CDD:406359	26/78 (33%)
		zf-H2C2_2	340..364	CDD:404364	11/30 (37%)
		C2H2 Zn finger	356..376	CDD:275368	7/19 (37%)
		C2H2 Zn finger	384..401	CDD:275368	7/17 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	402..424
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24399
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100