DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10321 and zbtb38

DIOPT Version :9

Sequence 1:	NP_001261124.1	Gene:	CG10321 / 37464	FlyBaseID:	FBgn0034643	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	XP_009292090.1	Gene:	zbtb38 / 101882192	ZFINID:	ZDB-GENE-091204-308	Length:	1265	Species:	Danio rerio

Alignment Length:	687	Identity:	131/687 - (19%)
Similarity:	233/687 - (33%)	Gaps:	172/687 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 HMPTLQPAPAQLLSAAGATTTMPQQI-LLPNGQLITTAQIVAPQLAQIISTAPQSTTNGQATAAQ 263
            |...:.|:.|.|::..|   |..:.| ::.:|.......:|.|....::.::......|..:..:
Zfish     7 HSGVVPPSDAHLIARTG---TRGKTISIMRSGMSKRKMTVVNPSTLGLVDSSHPQAVLGHLSEQR 68

  Fly   264 SQFL----------------PQLLQTPNGQTLQIVQQPNGTQTLQLVQLVPQRSLAPTGVTTV-- 310
            ||.|                ..:|...:|......:.|....:.|:::|...||.....:...
Zfish    69 SQGLFCDVIIVVEDVKFRAHRNILAATSGYFRNAFKTPEVYTSSQVLELTDLRSEVFASILNFIY 133

  Fly   311 ---TTTTNATDMGQHV--GASLGDADVQLLEDGCEVEDEELEDVYEQLDSKADHSFETIVLDDDQ 370
               ..:::..|....|  |..||...::.|.|. |.:...|.........|..:|...:......
Zfish   134 NARVESSSTEDKNSLVAAGKRLGIPFLEKLLDS-ERKSSGLLQCQASSSCKISNSQSKLAESCTL 197

  Fly   371 QQDFLKDHHEHHQVMINEDLTQSES-----QDHEYFDDLDQQQAMDEIEDEEEQMKPEEDQDTFI 430
            :::.||.  |..:......:|.:.|     ..|..|..|:|:..:  ||:.||...|...||| .
Zfish   198 KKEILKP--EELECSKGPRITNAFSITEGGTVHNPFSTLNQRNKV--IENFEEGHPPSSPQDT-S 257

  Fly   431 IEEIQLEDDEMLDDPDGEEIDQDCEYIGEEQDPHLSGDVDDDLEYSIMEPPDGETSVDIDQAFMD 495
            |..::.|....|:: ....:.|     |:|....:.|:.:..:   |...|..:|.|......:.
Zfish   258 ISAVESEPAHALNE-HSYAVSQ-----GQESKEVIQGNDNGTI---IPAVPPAKTVVTHRLGPIK 313

  Fly   496 SEQSHHQQHQEEMQSISLENAVVEFSQATTTTEALVGPTMTVSSASPTPKRAKRSNHQIPAGVTL 560
            ..:.|:.......|:.:..:.:...|.|...|.|.:......|.|:|          :|.:.:.|
Zfish   314 KRRIHNSIPSLSSQTGATGSTIAGTSAAENATAAPISSPQLSSDAAP----------EIDSSLDL 368

  Fly   561 EP-------CDHQPPAAGSTTSSKLAAANSRQLVQTASVIAAAGADDNYEIDANLVTEFIRQHTS 618
            .|       .|.:||......:..:...:.:|..:|.:             |:.|:|..::.|.
Zfish   369 LPPLDVTPSQDAEPPCLSPQNTDYVPTFSCKQCPETFN-------------DSTLLTIHMQIHK- 419

  Fly   619 PLGSGRYICHL----CSTEFRQFKGLQNHMHSHTNWIRANCKKQPQCQICLKSFKGPGMLRMHMK 679
                 |::.||    |..:|...|.|:||.                 |:|:||.|||..|..:.|
Zfish   420 -----RFVSHLFCKYCRKKFMHLKRLRNHE-----------------QVCVKSLKGPSELETNNK 462

  Fly   680 ----------THDAE-----------------------------------------SSTPMCTIC 693
                      |::|.                                         |.|..|::|
Zfish   463 DSLRVPDTNSTYNANTTQQSLPPPDLNIPLSLDPTSTCPLEMSQDQVNGTLKTNGTSRTYKCSVC 527

  Fly   694 NRTFKSKAILYRHRQTHQ-QRAYCCGVANCRKNFSSA-VNLK---WHV-ERKHPEVVDPLFKCGE 752
            .|.:.:.:.|.||...|. .|||.|..  |.|.|:.| ...|   ||. ||:        ::|..
Zfish   528 KRAYVTLSSLKRHENVHSWHRAYPCHY--CNKVFALAEYRTKHEIWHTGERR--------YQCIF 582

  Fly   753 CGSLYDNVDSLQLHVESTDHSAEVQISGQDDAFSGAV 789
            |...:.....|:.|.:|. |..:.|::....:.:|.:
Zfish   583 CLETFLTYYILKNHQKSF-HGIDPQLAVNKKSANGGL 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10321	NP_001261124.1	zf-AD	12..80	CDD:214871
		ASF1_hist_chap	<405..516	CDD:304562	22/110 (20%)
		C2H2 Zn finger	627..647	CDD:275368	8/23 (35%)
		C2H2 Zn finger	661..681	CDD:275368	9/29 (31%)
		C2H2 Zn finger	690..710	CDD:275368	6/19 (32%)
		C2H2 Zn finger	717..740	CDD:275368	10/27 (37%)
		C2H2 Zn finger	750..767	CDD:275368	3/16 (19%)
zbtb38	XP_009292090.1	BTB	64..163	CDD:279045	15/98 (15%)
		BTB	75..171	CDD:197585	15/96 (16%)
		C2H2 Zn finger	398..418	CDD:275368	5/32 (16%)
		C2H2 Zn finger	427..446	CDD:275368	6/35 (17%)
		C2H2 Zn finger	524..544	CDD:275368	6/19 (32%)
		C2H2 Zn finger	552..572	CDD:275368	6/21 (29%)
		C2H2 Zn finger	580..598	CDD:275368	4/17 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24399
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100