DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10321 and zbtb34

DIOPT Version :9

Sequence 1:	NP_001261124.1	Gene:	CG10321 / 37464	FlyBaseID:	FBgn0034643	Length:	855	Species:	Drosophila melanogaster
Sequence 2:	NP_001116183.1	Gene:	zbtb34 / 100004439	ZFINID:	ZDB-GENE-050624-2	Length:	508	Species:	Danio rerio

Alignment Length:	567	Identity:	99/567 - (17%)
Similarity:	180/567 - (31%)	Gaps:	195/567 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   271 LQTPNGQTLQIVQQPNGTQTLQLVQLVPQRSLAPTGVTTVTTTTNATDMGQHVGASLGDADVQLL 335
            |.|.:|.::.:::.|...:.|.......:.:|....|.:..|..:...|             |.:
Zfish    64 LGTMSGLSISVIKSPEVFEQLLAFCYTGRMALRLRDVISFLTAASFLQM-------------QAV 115

  Fly   336 EDGCEVEDEELEDVYEQLDSKADHSFETIVLDDDQQ-------------------------QDFL 375
            .|.|   .:.||.::.::...|...     :|.|.:                         ..|.
Zfish   116 IDKC---TQILEGIHSKISIPASGE-----IDPDNECTTSRAGRNGVKDRGIFVNPTEISPSHFS 172

  Fly   376 KDHHEHHQVMINEDLTQSESQDHEYFDDLDQQQAMDEIEDEEEQMKPEEDQDTFIIEEIQLEDDE 440
            :.:|........:.:.:....|....|.:.:|:|..|:|.|:.::
Zfish   173 RQNHCMEGQSSGKGIAEEGQSDRGSSDSISEQEASMEVESEQVEL-------------------- 217

  Fly   441 MLDDPDGEEIDQDCEYIGEEQDPHLSGDVDDDLEYSIMEPPDGETSVDIDQAFMDSEQSHHQQ-- 503
                     |.:|    |:..|.|:..:..|...||     |..::.|         ..:|.:
Zfish   218 ---------IGKD----GQVTDVHIKLEKTDRPSYS-----DSSSAGD---------DGYHTELV 255

  Fly   504 HQEEMQSISLENAVVEFSQATTTTEALVGPT---MTVSSASPT-------------PKRAKRSNH 552
            ..|::.::|:.:.:...|....|..||  |:   :::||:||:             |||..
Zfish   256 DGEQVLAVSVGSYMPVLSSVGYTYSAL--PSSCFVSLSSSSPSRSLLSSVRGGRARPKRPV---- 314

  Fly   553 QIPAGVTLEP----CDHQPPAAGSTTSSKLAAANSRQLVQTASVIAAAGADDNYEIDANLVTEFI 613
            .:|..:..:|    .:.:|||..:|                            :|.|..  ...:
Zfish   315 PLPVDMLTQPKPGADEGEPPATTAT----------------------------FENDVR--ERSL 349

  Fly   614 RQHTSPLGSGRYICHLCSTEFRQFKGLQNHMHSH---TNWIRANCKKQPQCQICLKSFKGPGMLR 675
            |....|... |.||..|...|.|...|..||..|   |.::         |:.|.|.:.....|.
Zfish   350 RGQWYPYNE-RLICIYCGKSFNQKGSLDRHMRLHMGITPFV---------CKFCGKKYTRKDQLE 404

  Fly   676 MHMKTHDAESSTPMCTICNRTFKSKAILYRHRQTHQQRAYCCGVANCRKNFSSAVNLKWHV---- 736
            .|::.| .::....|.||.:.|..:..|.:|.:              :|:.:|...:..|.
Zfish   405 YHIRGH-TDNKPFHCQICGKCFPFQGTLNQHLR--------------KKHMTSGTEINNHTDLLE 454

  Fly   737 -----ERKHPEVVDPLFKCGE--CGSLY-DNVDSLQLHVESTDHSAE 775
                 :|...|.:..    ||  ||:.| |::.......||...|.|
Zfish   455 EAPDGQRGEQEDISE----GEAACGAAYPDDLSKKSPSEESGKCSPE 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10321	NP_001261124.1	zf-AD	12..80	CDD:214871
		ASF1_hist_chap	<405..516	CDD:304562	18/112 (16%)
		C2H2 Zn finger	627..647	CDD:275368	7/19 (37%)
		C2H2 Zn finger	661..681	CDD:275368	5/19 (26%)
		C2H2 Zn finger	690..710	CDD:275368	6/19 (32%)
		C2H2 Zn finger	717..740	CDD:275368	4/31 (13%)
		C2H2 Zn finger	750..767	CDD:275368	6/19 (32%)
zbtb34	NP_001116183.1	BTB	23..123	CDD:279045	12/74 (16%)
		BTB	34..124	CDD:197585	12/75 (16%)
		CENP_C_N	<181..>267	CDD:292255	20/132 (15%)
		ZnF_C2H2	360..382	CDD:197676	8/21 (38%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		zf-H2C2_2	374..399	CDD:290200	8/33 (24%)
		C2H2 Zn finger	390..410	CDD:275368	5/19 (26%)
		zf-H2C2_2	403..425	CDD:290200	6/22 (27%)
		C2H2 Zn finger	418..436	CDD:275368	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24399
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100