DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mahj and DCAF1

DIOPT Version :9

Sequence 1:	NP_001246451.1	Gene:	mahj / 37462	FlyBaseID:	FBgn0034641	Length:	1544	Species:	Drosophila melanogaster
Sequence 2:	NP_194845.4	Gene:	DCAF1 / 829244	AraportID:	AT4G31160	Length:	1883	Species:	Arabidopsis thaliana

Alignment Length:	1961	Identity:	455/1961 - (23%)
Similarity:	739/1961 - (37%)	Gaps:	569/1961 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 DGGEPEADEDADADDAMSVENAENESD-SGGNAEETAAADRRQATKKELTQIIDKWEQQQTQNGY 129
            ||.|.....::..:|..||..||..:: :....|........|:.:.||.....|..:..|....
plant     2 DGQEHAEVPNSMVEDDQSVVAAEAIAELANSTGEPNPEEGEEQSVEDELIAKAQKLMEDITSVAN 66

  Fly   130 DPVPT-LRSLAEIFEREKDVYRRKDPDPLDSRHPYRADPSCQYGLLLKLLFRKDTFMGKLLNDYL 193
            :|.|. |.:|:::.|.::.::..      ::.|...|..|...|.|..|:...|.|...:.:.:|
plant    67 NPNPNILHALSQLLESQESLFLE------ENGHFSNARGSHNSGKLCILIRENDEFFELISSTFL 125

  Fly   194 RENYFSRQNVSRSSLELNILACRLILEIMPGMETSAVFQTAEGDGTINRIYSW---------AED 249
            .||.:|.. |..:|..| ::.|.|          :.::.....|.......:|         .||
plant   126 SENSYSTA-VKAASARL-LMNCSL----------TWMYPHVFDDAVTENFKNWVMEEAVKFPGED 178

  Fly   250 S-------IEPLQSYATGLLAEAME-----VSDIAINFRDLNIRLVPKMIKRLHMLLAISKSATS 302
            |       .|.|::|:|||||.::.     |.|:      |...|..|::..|.:.: :.:.:||
plant   179 SAKKEASDFEMLKTYSTGLLALSLASRGQIVEDV------LTSGLSAKLMHYLRVRV-LKEPSTS 236

  Fly   303 DVNTSM--------------------------HNLSADS-----------------------STA 318
            .::|:.                          |.|..||                       :.:
plant   237 RIHTTETKHVSLKTKEEGRSRVRKIVDTVEGDHVLETDSGREMGQTDVQPDGEFEIDGRDVFNVS 301

  Fly   319 GMLSWVAC----ASNASAPQSPQ---------------HNG------------------------ 340
            |:   |.|    ..:.|....|.               |.|
plant   302 GV---VDCKIKPGDDNSVRDDPSRHRLNRSKSRGRGRVHEGAPDTEVLLASPRLGRLLVRDRDLS 363

  Fly   341 -------------------SGL------------------------------GASSSQ----H-- 350
                               ||:                              ||:.::    |
plant   364 KISDGRNAEDVTVCLGKMKSGIMEIEREDNDECFQGCIIGTKNITDLVKRAVGAAETEARAAHAP 428

  Fly   351 -------GDASNMSIL------FENSR-----------------DAFSVSRY-----------YK 374
                   |||:...:.      |::|.                 ||..|||.           ..
plant   429 DDAAKAAGDAAAELVKTAALEEFKSSGSEEAAVSAATRAAITVIDAAEVSRNPTCVTSDQTTDVS 493

  Fly   375 RMYIPLHPATADTSQMLIMRFLTSLGEYQEFLAMAFENNVMQLIFGYLE---NLDRRDTC--LAY 434
            .:.:|...:.|...:...::.|..||||.|.|........:.:....||   .||.|.|.  |..
plant   494 EVSLPDIESLAQLQEKYCIQCLEILGEYVEVLGPVLHEKGVDVCIVLLERTSQLDDRSTVSPLLP 558

  Fly   435 EVLKYLASLLCHKKFALEFISHGGLELLLKVPRPSLATTGVSIAIYYLAYCEDAMERICSMQRPL 499
            :|:|.:.:|..|:|||..|:...|:..||.|||.|....|:|..:|.:...:..|||:|::...:
plant   559 DVMKLICALAAHRKFAAMFVERRGILKLLAVPRVSETFYGLSSCLYTIGSLQGIMERVCALPLVV 623

  Fly   500 ISELVRYALWILGRCHDSSKCHATMFFSLSFQFKVILDEFDAQDGLRKLYNVISVLKILDPSHND 564
            |.::|:.|:.:|....|.::.::.:||:.:|.|:.|||.|||||.|:||   :::||........
plant   624 IHQVVKLAIELLDCSQDQARKNSALFFAAAFVFRAILDAFDAQDSLQKL---LAILKDAASVRTG 685

  Fly   565 SDNDSDFNEDVECASRQMVRHVCVALKRYMEAHFFYKYNSFLCQTNAASPAPSSAHYFNQNPTV- 628
            ::.|....|.:..:.:||..|.|.||::|..||.....:|......:....|||     ..|.:
plant   686 ANTDRSAPEVMTSSEKQMAFHTCFALRQYFRAHLLLLVDSIRPSRISRGGVPSS-----MKPNIR 745

  Fly   629 AAKLTFDQLNDQIRT----LQEH-----TSIRAHWQPVDQLMKLGGITMLLRIIAFSYDWVNSGR 684
            ||....|..|:.:..    ||:.     |.::|.|..|:..:...|...:|.:.  ....|:...
plant   746 AAYKPLDISNEAVDAIFLQLQKDRRLGPTFVKAQWPAVNNFLASSGHVTMLELC--QTPPVDRYL 808

  Fly   685 SETVRSALDVLSVCCIIPRVYVVLCERLLMLDKTTTSGFCSVLGAAAGEISS---DAEVIKSALA 746
            .:.::.|..||.:...||.....:....|   ....:|...:|.||  .||:   |.|:|:.||.
plant   809 HDLLQYAFGVLHIVTSIPDGRKAIAHATL---SNNRAGIAVILDAA--NISNSIVDPEIIQPALN 868

  Fly   747 VLCHCVCSPIIRKDSGTSL------------------------IKFGTSSRKNKANHKYA----- 782
            ||.:.||.|       .||                        :..||.|..|......|
plant   869 VLINLVCPP-------PSLSNKPPLAQNHQPVPGQATTRPSTDVAVGTQSTGNAPQTPVAPASSG 926

  Fly   783 ----------------------EELIERVWESVCSNNGIVVLLSLMQTK---GPITDADCIRGMA 822
                                  |::..:..|:|..|:||.:||.|:|.:   .|....||:|.:|
plant   927 LVGDRRIFLGAGTGSAGLAAKLEQVYRQAREAVRGNDGIKILLKLLQPRIYVNPPATPDCLRALA 991

  Fly   823 CRALAGLARSDRVRQIVSKLPLFASGQLQTLMRDPILQEKRAEHVIFQ----KYALELLERVSGK 883
            ||.|.||||.|.:.||::||.:..|  |..|:||...|....:...:|    :.||||:..|:..
plant   992 CRVLLGLARDDTIAQILTKLEVGKS--LSELIRDSGGQSSGTDQGRWQAELAQVALELIGIVTNS 1054

  Fly   884 ----TKPLNNPLDPSLSNMHKANVIAQTRIQYNKQQLYQLIFEHLESNGLSQTAQMLQREVGL-P 943
                |...::...|:|..:.:|.:.|.|.|.|:.::|..||.|||:::||..||..|.:|..| |
plant  1055 GHATTLTASDAATPTLRRIERAAIAAATPITYDSKELLLLIHEHLQASGLGDTASALLKEAQLTP 1119

  Fly   944 LQT---------PTTRSFHQSPFDYKSLPSGSSS----LSRNRLRSRMQD----VNAAIMG---- 987
            |.:         .||:.. .:|...:..|||.::    .|:.::.:..:|    .|||:..
plant  1120 LPSSASPSSIAYSTTQEM-STPLAQEQWPSGRANSGFFTSKPKVCAHDEDPNSRSNAALSAKKKH 1183

  Fly   988 ------------------NGDLNRSF--------GEDSSPAGAGGSNAGDGVS------IPNFSS 1020
                              :|..|..|        ..|..|:..|  ||.....      .|:|||
plant  1184 LASSTLEMPTPVAQQQWPSGRANCGFCPSIPKINARDEDPSSRG--NAAPSAKKKQLTFSPSFSS 1246

  Fly  1021 LNTTQ-----------------------------------------------TPIKIRRTDRSSV 1038
            .:..|                                               |||...|..:.|.
plant  1247 QSRKQSFSHDALPQSTQRINCCSNSDPALADTSETAAELVLKNDLDADAQFKTPISFPRKRKLSE 1311

  Fly  1039 SR-----------------------SIQKQAMEPGGMSVGLAEDGQL---------------HPK 1065
            .|                       .:|..|........|.:..||:               :|:
plant  1312 LRDSSVPGKRIDLGERRNSTFADGSGLQTPASALDANQSGSSRLGQMTPASQLRLPSDPQPSNPE 1376

  Fly  1066 RITLNTIVTEYLTNQHSLCNNPVTTCPQFDLYEPHKCPDPKPSRLLSSNYNLTSRHARTQ----- 1125
            |::|:::|.:||.:||..|..|:||.|...|..||.||:||  |||.:..|:|.|....:
plant  1377 RLSLDSLVVQYLKHQHRQCLAPITTLPPVSLLHPHVCPEPK--RLLEAPLNMTGRLGTRELQSFY 1439

  Fly  1126 AGFNTSRFDRRYVHTHFSPWRSIRSADYEDLEFTCCDLAG--KYIIVGTQQGDGRVFNMNDGVEQ 1188
            :|.:.:|.||::|.:.|..|||.|.   |...|||..|.|  .:|.||:..|:.::|..:.|...
plant  1440 SGVHGNRRDRQFVFSRFKSWRSFRD---ETALFTCIALLGGTNHIAVGSHAGEIKIFEASSGSML 1501

  Fly  1189 FFSNCHNFSVDAIK--ANRAGDLVITSSFWRTPTSILWSIADDEFKLKLRLPDVTYCEFSQT-VQ 1250
            ...:.|...|..::  .:|...|:::||   :....||..:......:.........:||.: :|
plant  1502 ESVSGHQAPVTLVQPYVSRDTQLLLSSS---SSDVQLWDASSITGGPRHSFDGCKAAKFSNSGLQ 1563

  Fly  1251 DRLLGTQ--NECATLFDINTGSKVASFTPTI----PNLYTKNRATLCRTDELILSDGVLWDVRSG 1309
            ...|..:  .:...|:|:.|.|.....|.|:    .|.|:....:.|  |.|||.:|||||.|..
plant  1564 FAALSCEASRKDVLLYDVQTCSPCQKLTDTVTSSRSNPYSLVHFSPC--DTLILWNGVLWDRRIP 1626

  Fly  1310 KEIHKFDKFNQCISGVFHPNCLEIIANTEVWDLRTFHLLQTVPVLDQRNCTFSPMHVIYGASLGA 1374
            :::.:||:|.....|.|||:..|:|.|:|:||:|||.||::||.|||...||:....:..|.|..
plant  1627 EKVRRFDQFTDYGGGGFHPSRNEVIINSEIWDMRTFKLLRSVPSLDQTAITFNSRGDVIYAMLRR 1691

  Fly  1375 DRDHDMETTTYD--------TSFNVLDAYDYSSIATIDVKRNINDLSVSANGSLIAVVEDYSGYE 1431
            :.: |:.:..:.        .:|..|||.:||.||||.|.|.:.|.:.....|.:.::.    .|
plant  1692 NIE-DVMSAVHTRRVKHPLFAAFRTLDAINYSDIATIPVDRCLLDFATEPTDSFLGLIT----ME 1751

  Fly  1432 SKQETY--VKIYAVGVKK--SERSEEEDDEEVPESDE----------------DGSDTGSENTFA 1476
            .:::.:  .::|.:|.::  .:.|:.:||:|..:.||                |.||:|.:
plant  1752 DQEDMFSSARMYEIGRRRPTDDDSDPDDDDETEDEDEDDEEEDDLDRILGLAGDNSDSGDD---- 1812

  Fly  1477 IGQNLLGFPLLRNLHGSDNDD--EDLDEDDD---DG---EPLDSDDDSDDDDGSDNGDDDGDFDV 1533
                        :|...||:|  .|.||:.|   ||   |.|...::.||.:|.|. |||.|.::
plant  1813 ------------DLSSEDNEDSVSDFDEEADILIDGDFMEELIEGENEDDGNGEDE-DDDDDGEM 1864

  Fly  1534 LEYFDRSSSDD 1544
            .::......||
plant  1865 QDFMSSGEEDD 1875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mahj	NP_001246451.1	LisH	912..944	CDD:128913	13/32 (41%)
		WD40	1159..>1350	CDD:295369	59/201 (29%)
		WD40 repeat	1159..1192	CDD:293791	10/34 (29%)
		WD40	1194..>1423	CDD:225201	73/245 (30%)
		WD40 repeat	1198..1236	CDD:293791	7/39 (18%)
		WD40 repeat	1241..1278	CDD:293791	9/39 (23%)
		WD40 repeat	1285..1316	CDD:293791	11/30 (37%)
		WD40 repeat	1322..1352	CDD:293791	15/29 (52%)
DCAF1	NP_194845.4	WD40	1451..>1687	CDD:225201	74/243 (30%)
		WD40	1470..1687	CDD:295369	66/221 (30%)
		WD40 repeat	1470..1506	CDD:293791	10/35 (29%)
		WD40 repeat	1512..1551	CDD:293791	6/41 (15%)
		WD40 repeat	1556..1595	CDD:293791	10/38 (26%)
		WD40 repeat	1603..1633	CDD:293791	11/31 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1832
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	394	1.000	Inparanoid score	I488
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D105679at2759
OrthoFinder	1	1.000	-	-		FOG0006308
OrthoInspector	1	1.000	-	-		oto4149
orthoMCL	1	0.900	-	-		OOG6_104588
Panther	1	1.100	-	-	LDO	PTHR13129
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5678
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.830