DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mahj and Dcaf1

DIOPT Version :9

Sequence 1:	NP_001246451.1	Gene:	mahj / 37462	FlyBaseID:	FBgn0034641	Length:	1544	Species:	Drosophila melanogaster
Sequence 2:	XP_006511816.1	Gene:	Dcaf1 / 321006	MGIID:	2445220	Length:	1516	Species:	Mus musculus

Alignment Length:	1543	Identity:	590/1543 - (38%)
Similarity:	857/1543 - (55%)	Gaps:	201/1543 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 TKKELTQIIDKWEQQQTQNGYDPVPTLRSLAEIFEREKDVYRRKDPDPLDSRHPYRADPSCQYGL 173
            :|.|||.::::||:.. .:|.|.||.|..::|:.|:|.:.||:.||||.|.|||.||||.|..|.
Mouse    20 SKAELTTLLEQWEKDH-GSGQDMVPILTRMSELIEKETEEYRKGDPDPFDDRHPGRADPECMLGH 83

  Fly   174 LLKLLFRKDTFMGKLLNDYLRENYFSRQNVSRSSLELNILACRLILEIMPGMETSAVFQTAEGDG 238
            ||::||:.|.||..|:|.|:.        .||.. .||..||||:|:||||:||:.|||  |.:|
Mouse    84 LLRILFKNDDFMNALVNAYVM--------TSREP-PLNTAACRLLLDIMPGLETAVVFQ--EKEG 137

  Fly   239 TINRIYSWAEDSIEPLQSYATGLLAEAMEVSDIAINFRDLNIRLVPKMIKRL------------- 290
            .:..::.||.::.:||::|:||||..|||..|||.|:||.|.:||..:::||
Mouse   138 IVENLFKWAREADQPLRTYSTGLLGGAMENQDIAANYRDENSQLVAIVLRRLRELQLQEVALRQD 202

  Fly   291 -----------HMLLAISKSATS--------DVNTSMHNLSADSSTAGML-SWVACASNASAPQS 335
                       ..||.:.:.|..        ||.......|.|...:..| |....:|..::...
Mouse   203 SKRPSPRKLSSEPLLPLDEEAVDMDYGDMAVDVVDGEQESSRDMEISFRLDSSHKTSSRVNSATK 267

  Fly   336 PQHNGSGLGASSSQHGDASNM---------------SILFENSRDAFS-VSRYYKRMYIPLHPAT 384
            |:..|.... .|::|||..|.               .:..|.|..::| :|.:.......|:|.|
Mouse   268 PEEGGLKKN-KSAKHGDRENFRKAKQKLGFSSSDPDRVFVELSNSSWSEMSPWVIGTNYTLYPMT 331

  Fly   385 ADTSQMLIMRFLTSLGEYQEFLAMAFENNVMQLIFGYLENLDRRDTCLAYEVLKYLASLLCHKKF 449
            ....|.||:::||.||||||.|.:..:....:|:..|::.....|..|.:|.||:|||||.|.||
Mouse   332 PAIEQRLILQYLTPLGEYQELLPIFMQLGSRELMMFYIDLKQTNDVLLTFEALKHLASLLLHNKF 396

  Fly   450 ALEFISHGGLELLLKVPRPSLATTGVSIAIYYLAYCEDAMERICSMQRPLISELVRYALWILGRC 514
            |.||::|||::.||::||||:|.||||:.:|||:|.:|||||:|.....::|::|.|.||::...
Mouse   397 ATEFVAHGGVQKLLEIPRPSMAATGVSMCLYYLSYNQDAMERVCMHPHNVLSDVVNYTLWLMECS 461

  Fly   515 HDSSKCHATMFFSLSFQFKVILDEFDAQDGLRKLYNVISVLKILDPSHNDSDNDSDFNEDVECAS 579
            |.|..||||||||:.|.|:.:|:.||..||||:|.|:||.|:||    |..|..:..::|...||
Mouse   462 HASGCCHATMFFSICFSFRAVLELFDRYDGLRRLVNLISTLEIL----NLEDQGALLSDDEIFAS 522

  Fly   580 RQMVRHVCVALKRYMEAHFFYKYNSF---LCQTNA---ASPAPSSAHYFNQNPTVAAKLTFDQLN 638
            ||..:|.|:||::|.|||...|....   |.:|..   ..|.|         |..|...|.:|:.
Mouse   523 RQTGKHTCMALRKYFEAHLAIKLEQVKQSLQRTEGGILVHPQP---------PYKACSYTHEQIV 578

  Fly   639 DQIRTLQEHTSIRAHWQPVDQLMKLGGITMLLRIIAFSYDW-VNSGRSETVRSALDVLSVCCIIP 702
            :.:..|.|:...:.:|:|.:..:||..:.:||::|:.:.:| ....|::|||.|||||::..::|
Mouse   579 EMMEFLIEYGPAQLYWEPAEVFLKLSCVQLLLQLISIACNWKTYYARNDTVRFALDVLAILTVVP 643

  Fly   703 RVYVVLCERLLMLDK----TTTSGFCSVLGAAAGE-ISSDAEVIKSALAVLCHCVCSPIIRKDSG 762
            ::.:.|.|.:.:||:    .:|.|...:||.|.|| ...|||:.||||.::.:|||.|    |:.
Mouse   644 KIQLQLAESVDVLDEAGSAVSTVGISIILGVAEGEFFIHDAEIQKSALQIIINCVCGP----DNR 704

  Fly   763 TSLI-KF--GTSSRKNKANHKYAEELIERVWESVCSNNGIVVLLSLMQTKGPITDADCIRGMACR 824
            .|.| ||  ||..||.....|.:|..:.::|..|.|||||.|||||:..|.||||||.||.:||:
Mouse   705 ISSIGKFISGTPRRKLSQTPKSSEHTLAKMWNVVQSNNGIKVLLSLLSIKMPITDADQIRALACK 769

  Fly   825 ALAGLARSDRVRQIVSKLPLFASGQLQTLMRDPILQEKRAEHVIFQKYALELLERVSGKTKPLNN 889
            ||.||:||..||||:||||||:|.|:|.||::|:||:||::||.|.|||.||:|||||  |||..
Mouse   770 ALVGLSRSSTVRQIISKLPLFSSCQIQQLMKEPVLQDKRSDHVKFCKYAAELIERVSG--KPLLI 832

  Fly   890 PLDPSLSNMHKANVIAQTRIQYNKQQLYQLIFEHLESNGLSQTAQMLQREVGLPLQTPTTRSFHQ 954
            ..|.||:.:.||:|:||:||.:.:::|..||..||.|.||.:||.:|.||..||:    |.:.|.
Mouse   833 GTDVSLARLQKADVVAQSRISFPEKELLLLIRNHLISKGLGETATVLTREADLPM----TAASHS 893

  Fly   955 SPFDYKSLPSGSSSLSRNRLRSRMQDVNAAIMGNGDLNRSFGEDSSPA--------GA----GGS 1007
            |.|...:..:...||.|.   .|:.:..|:.:|:.....:....:.||        |:    |.|
Mouse   894 SAFTPVTAAASPVSLPRT---PRIANGIASRLGSHATVGASAPSAPPAHPPPRPPQGSLPLPGPS 955

  Fly  1008 NAGDGVSIPNFSSLNTTQTPI---KIR----RTDRSSVSRS--IQKQAMEPGGMSVGLAEDGQLH 1063
            .||:...|...|.:....:|.   |||    ::|..:.|:|  |:||.            |..|
Mouse   956 YAGNSPLIGRISFIRERPSPCNGRKIRVLRQKSDHGAYSQSPAIKKQL------------DRHL- 1007

  Fly  1064 PKRITLNTIVTEYLTNQHSLCNNPVTTCPQFDLYEPHKCPDPKPSRLLSSNYNLTSRHARTQA-- 1126
            |...||::|:||||..||:.|.|||.|||.|.|:.||:||:||..|  .:..|.|||..|..:
Mouse  1008 PSPPTLDSIITEYLREQHARCKNPVATCPPFSLFTPHQCPEPKQRR--QAPINFTSRLNRRASFP 1070

  Fly  1127 ---GFNTSRFDRRYVHTHFSPWRSIRSADYEDLEFTCCDLAG--KYIIVGTQQGDGRVFNMNDGV 1186
               |.:...|||..:.:.|.|....|.|:.::..||||..:.  :::::||..|..:::|:..|.
Mouse  1071 KYGGVDGGCFDRHLIFSRFRPISVFREANEDESGFTCCAFSARERFLMLGTCTGQLKLYNVFSGQ 1135

  Fly  1187 EQFFSNCHNFSVDAIKANRAGDLVITSSFWRTPTSILWSIADDEFKLKLRLPDVTYCEFSQTVQD 1251
            |:...||||.::..::.:|.|.|::||:.|..|.|.||.: ...|.:|....:..|.|||:..||
Mouse  1136 EEASYNCHNSAITHLEPSRDGSLLLTSATWSQPLSALWGM-KSVFDMKHSFTEDHYVEFSKHSQD 1199

  Fly  1252 RLLGTQNECATLFDINTGSKVAS-FTPTIPNLYTKNRATLCRTDELILSDGVLWDVRSGKEIHKF 1315
            |::||:.:.|.::||.||:|:.: |.|.:.|.|.:|.||...||:|:|:|||||||||.:.||||
Mouse  1200 RVIGTKGDIAHIYDIQTGNKLLTLFNPDLANNYKRNCATFNPTDDLVLNDGVLWDVRSAQAIHKF 1264

  Fly  1316 DKFNQCISGVFHPNCLEIIANTEVWDLRTFHLLQTVPVLDQRNCTFSPMH---VIYGASLGADRD 1377
            ||||..||||||||.||:|.|||:|||||||||.|||.|||....|:  |   |:|||.|.||.:
Mouse  1265 DKFNMNISGVFHPNGLEVIINTEIWDLRTFHLLHTVPALDQCRVVFN--HTGTVMYGAMLQADDE 1327

  Fly  1378 HDM----ETTTYDTSFNVLDAYDYSSIATIDVKRNINDLSVSANGSLIAVVEDYSGYES-KQETY 1437
            .|:    ..:.:.:||...:|.||..||||||||||.||........:||:|:....:: ..:|.
Mouse  1328 DDLLEERMKSPFGSSFRTFNATDYKPIATIDVKRNIFDLCTDTKDCYLAVIENQGSMDALNMDTV 1392

  Fly  1438 VKIYAVGVKK--SERSEEEDDEEVPESDEDGSDTGSENTFAIGQNLLGFPLLRNLHGSDNDDEDL 1500
            .::|.||.::  .:..||||.||..:.:||                              ||||
Mouse  1393 CRLYEVGRQRLAEDEDEEEDQEEEEQEEED------------------------------DDED- 1426

  Fly  1501 DEDDDDGEPLDSDD----DSDDDDGSDNGDDDGDFDVLEYFDRSSSDD 1544
            |:|.||.:.||:|.    :.::||.::|..:|||.|.      |.||:
Mouse  1427 DDDTDDLDELDTDQLLEAELEEDDNNENAGEDGDNDF------SPSDE 1468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mahj	NP_001246451.1	LisH	912..944	CDD:128913	14/31 (45%)
		WD40	1159..>1350	CDD:295369	91/193 (47%)
		WD40 repeat	1159..1192	CDD:293791	9/34 (26%)
		WD40	1194..>1423	CDD:225201	113/236 (48%)
		WD40 repeat	1198..1236	CDD:293791	12/37 (32%)
		WD40 repeat	1241..1278	CDD:293791	16/37 (43%)
		WD40 repeat	1285..1316	CDD:293791	19/30 (63%)
		WD40 repeat	1322..1352	CDD:293791	24/29 (83%)
Dcaf1	XP_006511816.1	WD40	1102..1320	CDD:392136	102/220 (46%)
		WD40 repeat	1106..1142	CDD:293791	9/35 (26%)
		WD40 repeat	1148..1230	CDD:293791	29/82 (35%)
		WD40 repeat	1271..1301	CDD:293791	24/29 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838960
Domainoid	1	1.000	928	1.000	Domainoid score	I39
eggNOG	1	0.900	-	-		E1_KOG1832
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8805
Inparanoid	1	1.050	930	1.000	Inparanoid score	I351
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48874
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006308
OrthoInspector	1	1.000	-	-		oto92905
orthoMCL	1	0.900	-	-		OOG6_104588
Panther	1	1.100	-	-	LDO	PTHR13129
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2475
SonicParanoid	1	1.000	-	-		X5678
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790