DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mahj and Dcaf1

DIOPT Version :9

Sequence 1:	NP_001246451.1	Gene:	mahj / 37462	FlyBaseID:	FBgn0034641	Length:	1544	Species:	Drosophila melanogaster
Sequence 2:	XP_038937498.1	Gene:	Dcaf1 / 315987	RGDID:	1305176	Length:	1556	Species:	Rattus norvegicus

Alignment Length:	1547	Identity:	591/1547 - (38%)
Similarity:	857/1547 - (55%)	Gaps:	209/1547 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 TKKELTQIIDKWEQQQTQNGYDPVPTLRSLAEIFEREKDVYRRKDPDPLDSRHPYRADPSCQYGL 173
            :|.|||.::::||:.. .:|.|.||.|..::|:.|:|.:.||:.||||.|.|||.||||.|..|.
  Rat    37 SKAELTTLLEQWEKDH-GSGQDMVPILTRMSELIEKETEEYRKGDPDPFDDRHPGRADPECMLGH 100

  Fly   174 LLKLLFRKDTFMGKLLNDYLRENYFSRQNVSRSSLELNILACRLILEIMPGMETSAVFQTAEGDG 238
            ||::||:.|.||..|:|.|:.        .||.. .||..||||:|:||||:||:.|||  |.:|
  Rat   101 LLRILFKNDDFMNALVNAYVM--------TSREP-PLNTAACRLLLDIMPGLETAVVFQ--EKEG 154

  Fly   239 TINRIYSWAEDSIEPLQSYATGLLAEAMEVSDIAINFRDLNIRLVPKMIKRL------------- 290
            .:..::.||.::.:||::|:||||..|||..|||.|:||.|.:||..:::||
  Rat   155 IVENLFKWAREADQPLRTYSTGLLGGAMENQDIAANYRDENSQLVAIVLRRLRELQLQEVALRQD 219

  Fly   291 -----------HMLLAISKSATS--------DVNTSMHNLSADSSTAGML-SWVACASNASAPQS 335
                       ..||.:.:.|..        ||.......|.|...:..| |....:|..::...
  Rat   220 NKRPSPRKLSSEPLLPLDEEAVDMDYGDMAVDVVDGEQEASRDMEISFRLDSSHKTSSRVNSATK 284

  Fly   336 PQHNGSGLGASSSQHGDASNM---------------SILFENSRDAFS-VSRYYKRMYIPLHPAT 384
            |:..|.... .|::|||..|.               .:..|.|..::| :|.:.......|:|.|
  Rat   285 PEEGGLKKN-KSAKHGDRENFRKAKQKLGFSSSDPDRVFVELSNSSWSEMSPWVIGTNYTLYPMT 348

  Fly   385 ADTSQMLIMRFLTSLGEYQEFLAMAFENNVMQLIFGYLENLDRRDTCLAYEVLKYLASLLCHKKF 449
            ....|.||:::||.||||||.|.:..:....:|:..|::.....|..|.:|.||:|||||.|.||
  Rat   349 PAIEQRLILQYLTPLGEYQELLPIFMQLGSRELMMFYIDLKQTNDVLLTFEALKHLASLLLHNKF 413

  Fly   450 ALEFISHGGLELLLKVPRPSLATTGVSIAIYYLAYCEDAMERICSMQRPLISELVRYALWILGRC 514
            |.||::|||::.||::||||:|.||||:.:|||:|.:|||||:|.....::|::|.|.||::...
  Rat   414 ATEFVAHGGVQKLLEIPRPSMAATGVSMCLYYLSYNQDAMERVCMHPHNVLSDVVNYTLWLMECS 478

  Fly   515 HDSSKCHATMFFSLSFQFKVILDEFDAQDGLRKLYNVISVLKILDPSHNDSDNDSDFNEDVECAS 579
            |.|..||||||||:.|.|:.:|:.||..||||:|.|:||.|:||    |..|..:..::|...||
  Rat   479 HASGCCHATMFFSICFSFRAVLELFDRYDGLRRLVNLISTLEIL----NLEDQGALLSDDEIFAS 539

  Fly   580 RQMVRHVCVALKRYMEAHFFYKYNSF---LCQTNA---ASPAPSSAHYFNQNPTVAAKLTFDQLN 638
            ||..:|.|:||::|.|||...|....   |.:|..   ..|.|         |..|...|.:|:.
  Rat   540 RQTGKHTCMALRKYFEAHLAIKLEQVKQSLQRTEGGILVHPQP---------PYKACSYTHEQIV 595

  Fly   639 DQIRTLQEHTSIRAHWQPVDQLMKLGGITMLLRIIAFSYDW-VNSGRSETVRSALDVLSVCCIIP 702
            :.:..|.|:...:.:|:|.:..:||..:.:||::|:.:.:| ....|::|||.|||||::..::|
  Rat   596 EMMEFLIEYGPAQLYWEPAEVFLKLSCVQLLLQLISIACNWKTYYARNDTVRFALDVLAILTVVP 660

  Fly   703 RVYVVLCERLLMLDK----TTTSGFCSVLGAAAGE-ISSDAEVIKSALAVLCHCVCSPIIRKDSG 762
            ::.:.|.|.:.:||:    .:|.|...:||.|.|| ...|||:.||||.::.:|||.|    |:.
  Rat   661 KIQLQLAESVDVLDEAGSTVSTVGISIILGVAEGEFFIHDAEIQKSALQIIINCVCGP----DNR 721

  Fly   763 TSLI-KF--GTSSRKNKANHKYAEELIERVWESVCSNNGIVVLLSLMQTKGPITDADCIRGMACR 824
            .|.| ||  ||..||.....|.:|..:.::|..|.|||||.|||||:..|.||||||.||.:||:
  Rat   722 ISSIGKFISGTPRRKLSQTPKSSEHTLAKMWNVVQSNNGIKVLLSLLSIKMPITDADQIRALACK 786

  Fly   825 ALAGLARSDRVRQIVSKLPLFASGQLQTLMRDPILQEKRAEHVIFQKYALELLERVSGKTKPLNN 889
            ||.||:||..||||:||||||:|.|:|.||::|:||:||::||.|.|||.||:|||||  |||..
  Rat   787 ALVGLSRSSTVRQIISKLPLFSSCQIQQLMKEPVLQDKRSDHVKFCKYAAELIERVSG--KPLLI 849

  Fly   890 PLDPSLSNMHKANVIAQTRIQYNKQQLYQLIFEHLESNGLSQTAQMLQREVGLPLQTPTTRSFHQ 954
            ..|.||:.:.||:|:||:||.:.:::|..||..||.|.||.:||.:|.||..||:    |.:.|.
  Rat   850 GTDVSLARLQKADVVAQSRISFPEKELLLLIRNHLISKGLGETATVLTREADLPM----TAASHS 910

  Fly   955 SPFDYKSLPSGSSSLSR-----NRLRSRMQDVNAAIMGNGDLNRSFGEDSSP------------- 1001
            |.|...:..:...||.|     |.:.||:.. :||:..:.        .|:|
  Rat   911 SAFTPVTAAASPVSLPRTPRIANGIASRLGS-HAAVGASA--------PSAPPAHPPPRPPQGSL 966

  Fly  1002 AGAGGSNAGDGVSIPNFSSLNTTQTPI---KIR----RTDRSSVSRS--IQKQAMEPGGMSVGLA 1057
            |..|.|.||:...|...|.:....:|.   |||    ::|..:.|:|  |:||.
  Rat   967 ALPGPSYAGNSPLIGRISFIRERPSPCNGRKIRVLRQKSDHGAYSQSPAIKKQL----------- 1020

  Fly  1058 EDGQLHPKRITLNTIVTEYLTNQHSLCNNPVTTCPQFDLYEPHKCPDPKPSRLLSSNYNLTSRHA 1122
             |..| |...||::|:||||..||:.|.|||.|||.|.|:.||:||:||..|  .:..|.|||..
  Rat  1021 -DRHL-PSPPTLDSIITEYLREQHARCKNPVATCPPFSLFTPHQCPEPKQRR--QAPINFTSRLN 1081

  Fly  1123 RTQA-----GFNTSRFDRRYVHTHFSPWRSIRSADYEDLEFTCCDLAG--KYIIVGTQQGDGRVF 1180
            |..:     |.:...|||..:.:.|.|....|.|:.::..||||..:.  :::::||..|..:::
  Rat  1082 RRASFPKYGGVDGGCFDRHLIFSRFRPISVFREANEDESGFTCCAFSARERFLMLGTCTGQLKLY 1146

  Fly  1181 NMNDGVEQFFSNCHNFSVDAIKANRAGDLVITSSFWRTPTSILWSIADDEFKLKLRLPDVTYCEF 1245
            |:..|.|:...||||.::..::.:|.|.|::||:.|..|.|.||.: ...|.:|....:..|.||
  Rat  1147 NVFSGQEEASYNCHNSAITHLEPSRDGSLLLTSATWSQPLSALWGM-KSVFDMKHSFTEDHYVEF 1210

  Fly  1246 SQTVQDRLLGTQNECATLFDINTGSKVAS-FTPTIPNLYTKNRATLCRTDELILSDGVLWDVRSG 1309
            |:..|||::||:.:.|.::||.||:|:.: |.|.:.|.|.:|.||...||:|:|:|||||||||.
  Rat  1211 SKHSQDRVIGTKGDIAHIYDIQTGNKLLTLFNPDLANNYKRNCATFNPTDDLVLNDGVLWDVRSA 1275

  Fly  1310 KEIHKFDKFNQCISGVFHPNCLEIIANTEVWDLRTFHLLQTVPVLDQRNCTFSPMH---VIYGAS 1371
            :.||||||||..||||||||.||:|.|||:|||||||||.|||.|||....|:  |   |:|||.
  Rat  1276 QAIHKFDKFNMNISGVFHPNGLEVIINTEIWDLRTFHLLHTVPALDQCRVVFN--HTGTVMYGAM 1338

  Fly  1372 LGADRDHDM----ETTTYDTSFNVLDAYDYSSIATIDVKRNINDLSVSANGSLIAVVEDYSGYES 1432
            |.||.:.|:    ..:.:.:||...:|.||..||||||||||.||........:||:|:....::
  Rat  1339 LQADDEDDLLEERMKSPFGSSFRTFNATDYKPIATIDVKRNIFDLCTDTKDCYLAVIENQGSMDA 1403

  Fly  1433 -KQETYVKIYAVGVKKSERSEEEDDEEVPESDEDGSDTGSENTFAIGQNLLGFPLLRNLHGSDND 1496
             ..:|..::|.||  :...:|:||:||..|.:|.                           .:.|
  Rat  1404 LNMDTVCRLYEVG--RQRLAEDEDEEEDQEEEEQ---------------------------EEED 1439

  Fly  1497 DEDLDEDDDDGEPLDSDD----DSDDDDGSDNGDDDGDFDVLEYFDRSSSDD 1544
            |||.|:|.||.:.||:|.    :.::||.::|..:|||.|.      |.||:
  Rat  1440 DEDDDDDTDDLDELDTDQLLEAELEEDDNNENAGEDGDNDF------SPSDE 1485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mahj	NP_001246451.1	LisH	912..944	CDD:128913	14/31 (45%)
		WD40	1159..>1350	CDD:295369	91/193 (47%)
		WD40 repeat	1159..1192	CDD:293791	9/34 (26%)
		WD40	1194..>1423	CDD:225201	113/236 (48%)
		WD40 repeat	1198..1236	CDD:293791	12/37 (32%)
		WD40 repeat	1241..1278	CDD:293791	16/37 (43%)
		WD40 repeat	1285..1316	CDD:293791	19/30 (63%)
		WD40 repeat	1322..1352	CDD:293791	24/29 (83%)
Dcaf1	XP_038937498.1	WD40	1119..1337	CDD:421866	102/220 (46%)
		WD40 repeat	1123..1159	CDD:293791	9/35 (26%)
		WD40 repeat	1165..1247	CDD:293791	29/82 (35%)
		WD40 repeat	1288..1318	CDD:293791	24/29 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342764
Domainoid	1	1.000	912	1.000	Domainoid score	I44
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8805
Inparanoid	1	1.050	912	1.000	Inparanoid score	I344
OMA	1	1.010	-	-		QHG48874
OrthoDB	1	1.010	-	-		D105679at2759
OrthoFinder	1	1.000	-	-		FOG0006308
OrthoInspector	1	1.000	-	-		oto96459
orthoMCL	1	0.900	-	-		OOG6_104588
Panther	1	1.100	-	-	LDO	PTHR13129
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5678
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910