DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mahj and dcaf-1

DIOPT Version :9

Sequence 1:	NP_001246451.1	Gene:	mahj / 37462	FlyBaseID:	FBgn0034641	Length:	1544	Species:	Drosophila melanogaster
Sequence 2:	NP_501725.2	Gene:	dcaf-1 / 177804	WormBaseID:	WBGene00014243	Length:	1701	Species:	Caenorhabditis elegans

Alignment Length:	1588	Identity:	489/1588 - (30%)
Similarity:	756/1588 - (47%)	Gaps:	257/1588 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 LTQIIDKWEQQQTQNGYDPVPTLRSLAEIFEREKDVYRRKDPDPLDSRHPYRADPSCQYGLLLKL 177
            :.:::.:::....|:.:||:|.|:.::|:.|:..|::.:.||||||.|||:|..|....|.:||:
Worm    33 IAELLLEFDANHEQSSFDPIPILKRISELLEQATDIFIKNDPDPLDDRHPHRTHPDSALGNILKI 97

  Fly   178 LFRKDTFMGKLLNDYLRENYFSRQNVSRSSLELNILACRLILEIMPGMETSAVFQTAEGDGTINR 242
            :|:.|.||.||:..|:         ::|.::||||...||:|..:||:::..||  :|.|..|.|
Worm    98 IFKNDDFMTKLVVSYI---------LARDNVELNIQGSRLLLACIPGLDSKVVF--SEPDDFIPR 151

  Fly   243 IYSWA--EDSIEPLQSYATGLLAEAMEVSDIAINFRDLNIRLVPKMIKRLHMLLAISKSATSDV- 304
            :|:||  |.:.|.||.||.||||.|:|.::.|..:|:.|..|||..::|||.|...|......:
Worm   152 LYTWAGSEGTNETLQGYAMGLLAAALENTENASKYRNENALLVPFGLRRLHELQGRSLEEQKKIG 216

  Fly   305 NTSMHNLSADSSTAGMLSWVACASNASAPQSPQHNGSGLGASS------SQHGDASNMSIL---- 359
            .|....|.|:.||:...| :......|...|.:.|......|:      .:..:....|:|
Worm   217 QTDFSQLHAEQSTSNGTS-IPSIKITSVDGSTKENEKTFVQSTDPPPPKKRRTEPCLTSLLRTEI 280

  Fly   360 ------FENSR---DAFSVSRYYKRMYI---PLHPATADTSQMLIMRFLTSLGEYQEFLAMAFEN 412
                  |.|.|   |:.|.....:...|   .::|.:..|.|..|:::|.:.||||:.|...||.
Worm   281 TQRVPSFHNLRNLDDSNSKWDILQPFLIGDQQVYPLSLATYQRFILQYLAACGEYQDLLLQTFEG 345

  Fly   413 NVMQLIFGYLENLDRRDTCLAYEVLKYLASLLCHKKFALEFISHGGLELLLKVPRPSLATTGVSI 477
            |.::::|.|::....:|..|.::.||||.|||.|:||||||::.||:..|||||:.|||:.||..
Worm   346 NALEILFDYIDLEKSKDVRLTFDALKYLTSLLVHRKFALEFVNKGGIPALLKVPKTSLASVGVVT 410

  Fly   478 AIYYLAYCEDAMERICSMQRPLISELVRYALWILGRCHDSSKCHATMFFSLSFQFKVILDEFDAQ 542
            .:||:||..|.||.:|.|...::.|.|:|.||.|...|:|....|.||||....:|.||..||..
Worm   411 CLYYIAYSNDVMEILCQMSDEIVDETVQYVLWCLEHSHESGMASACMFFSQGLFYKAILRRFDQY 475

  Fly   543 DGLRKLYNVISVLKILDPSHNDSDNDSDFNEDVEC------ASRQMVRHVCVALKRYMEAHFFYK 601
            ||.|||:|.|:.|.::..           |||||.      .|.|..|.||...:.|:.||.|.|
Worm   476 DGPRKLHNYIATLTLMQN-----------NEDVELTEEQIHTSTQCTRGVCTTFRSYLTAHIFIK 529

  Fly   602 YNSFLCQTNAASPAPSSAHYFNQNPTVAAKLTFDQL--NDQIRTLQEHTSIRAH----WQ----- 655
            ..::            ...|.|..||   .:.|.:|  .|    ..::.|::.:    ||
Worm   530 VENY------------KKLYGNNLPT---GMRFPELVQGD----CPDYKSMKPYEEVCWQCEAIV 575

  Fly   656 ------------PVDQLMKLGGITMLLRIIAFSYDWVN---SGRSETVRSALDVLSVCCIIPRVY 705
                        ..:.|.|||.:.|.|.:...|.||.|   |.|:|....||:.|.:...:|.:.
Worm   576 TEMLRFTGSSFREAENLRKLGMVRMFLAVRVLSRDWENISPSLRTEMCVHALETLCMMFCLPSIQ 640

  Fly   706 VVLCERLLMLDKTTTSGFCSVLGAAAGEISSDAEVIKSALAVLCHCV-----C-SPIIRKDSGTS 764
            ..|..: ...:.:...||..:|..:.|....|..:..:||..:..||     | ..||::...:.
Worm   641 TELITQ-HSYNHSNYDGFTILLQTSLGRYDEDPSLRMAALGCIQRCVYVEPECWKAIIQRVKSSE 704

  Fly   765 LIKFGTSSRKNK----ANHKYAEELIERVWESVCSNNGIVVLLSLMQTKGPITDADCIRGMACRA 825
            ......|.|::|    .||      :||:|..|...:||:.|::|:..|.|:|:||.||..|...
Worm   705 EKSSSASKRQSKYEIIMNH------LERMWTEVRKTDGIMALVNLINCKIPLTEADSIRKTATNT 763

  Fly   826 LAGLARSDRVRQIVSKLPLFASGQLQTLMRDPILQEKRAEHVIFQKYALELLERVSGKT------ 884
            |.||||...||||::||||.|...||.|||:|:..:||..|..|.|.|::||:.:.|:.
Worm   764 LTGLARHPEVRQILAKLPLIAHNGLQNLMREPVCSDKRDIHAAFCKEAVQLLQVIYGRKIHDQQG 828

  Fly   885 KPLNNPLDPSLSNMHKANVIAQTRIQYNKQQLYQLIFEHLESNGLSQTAQMLQREVGLPLQTPTT 949
            |.:.     |....|:..||..|::.:|:.:|.|||.:||..:.|...|.||:.|..|| ..|.:
Worm   829 KEIQ-----SSEKSHRQWVIENTQVSFNQAELLQLIHDHLLKSKLDSVAAMLKSEAKLP-DRPAS 887

  Fly   950 RSFHQSPFDYKSLPSGSSSLSR----------NRLRSRMQDVNAAIMGNGDLNRSFGEDSSPAGA 1004
            ||.: :|...|.|||..::.|:          ..|.|.:..::|....|.      ...||||.|
Worm   888 RSIN-TPILNKPLPSSGNNFSKINDTYPTLAPRTLESEIGGISARRPSNA------ASLSSPAMA 945

  Fly  1005 GGSNAGDGVSIPNFSSLNTTQTPIKIRRTDRSS-------VSRSIQK-QAMEPGGMSVGLAEDGQ 1061
            ..|::.|.         :...||...||...|.       :|.:.|| :.:.||..|.|
Worm   946 TRSHSTDD---------DVFATPTLPRRYTTSGAFPKKLMISPARQKLRPLTPGESSSG------ 995

  Fly  1062 LHPKRITLNTIVTEYLTNQHSLCNNPVTTCPQFDLYEPHKCPD-------PKPSRLLSSNYNLTS 1119
            ..|.: .||:|||:|..||||.|.|||||||.|.|:..||||:       .:...|.:.:..|..
Worm   996 YRPIK-DLNSIVTDYFRNQHSTCKNPVTTCPPFSLFYQHKCPELSYQTNVVRNISLRTLDQELLR 1059

  Fly  1120 RHARTQAGFNTSRFDRRYVHTHFSPWRSIRSAD--YEDLEFTCCDLAGKYIIVGTQQGDGRVFNM 1182
            .|.|..:.:.    :.|.:.:.|..|::|...|  |....|:..|   :::|||...|:....|:
Worm  1060 PHERVYSQWT----NERTIFSRFRNWKTIHDHDESYTKATFSVDD---EHLIVGLFNGEVHWINV 1117

  Fly  1183 NDGVEQFFSNCHNFSVDAIKANRAGDLVITSSFWRTPTSILWSIADDEFKLKLRLPDVTYCE--- 1244
            :.|:::..:|||..::..|:.::.|.:::|||.:..|.|.||.:.:...::.      ||.|
Worm  1118 DTGLDEGHTNCHGSALTNIEPSKDGSMMLTSSAFSRPLSALWRLGEALQRVH------TYREDSC 1176

  Fly  1245 --FSQTVQDRLLGTQNECATLFDINTGSKVASFTPTIPNL-YTKNRATLCRTDELILSDGVLWDV 1306
              |:.|...|::||..:.||::|..|...:.::...|..| |.||.|:....|:||.:||:||||
Worm  1177 VKFANTTMQRIVGTCRDKATVYDTETNHVLDTYLSGIDGLQYEKNYASFSPDDKLIFNDGLLWDV 1241

  Fly  1307 R-SGKEIHKFDKFNQ-CISGVFHPNCLEIIANTEVWDLRTFHLLQTVPVLDQRNCTF-SPMHVIY 1368
            | ....||.||:.:: .:.|.|||:..:|:.|:||:|:|||.:|..||.|::...:| |..:::|
Worm  1242 RKKNSAIHVFDRLSKITLFGTFHPHGTQIVINSEVYDIRTFRMLHHVPELNRCQVSFNSTGNIMY 1306

  Fly  1369 GASLGADRDHDMETTTYD----TSFNVLDAYDYSSIATIDVKRNINDLSVSANGSLIAVVE---- 1425
            ...:     .|:....||    :||...:..|||::.|.:.:|.:.||..|.....:.|:|
Worm  1307 ATEV-----TDVHCPDYDEKIFSSFRTFETRDYSALTTFEGRRPVIDLCASHQDQKMCVIEKVRP 1366

  Fly  1426 DYSGYESKQETYVKIYAVGVKK---SERSEEEDDE-EVPESDEDGSDTG-SENTFAIGQNLLG-- 1483
            ..|.|..:..|.:||..:|..|   .|..||||:: |..:.|||..::| .::...||.|...
Worm  1367 QMSDYMIQASTQLKIVEIGRLKDNEDENDEEEDEQREDHDEDEDSDESGDGDDDEEIGGNSSDRE 1431

  Fly  1484 --FPLLRNL-----HGSDNDDED-------------------------LDEDDDDGEPLDSDDDS 1516
              |..|..|     .||..||.|                         |:..::|.| |...|:.
Worm  1432 SVFRTLGRLGDESDSGSSVDDNDTLDDLDFENAQNRIIRRQAQRRRQRLNSSENDAE-LPGSDEG 1495

  Fly  1517 DDDDGSDNGDDDGDFDVLEYFDRSSSDD 1544
            .|:||.|:.|.:||.|    ||..::.|
Worm  1496 SDEDGDDDEDGEGDPD----FDMGAAID 1519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mahj	NP_001246451.1	LisH	912..944	CDD:128913	13/31 (42%)
		WD40	1159..>1350	CDD:295369	64/198 (32%)
		WD40 repeat	1159..1192	CDD:293791	7/32 (22%)
		WD40	1194..>1423	CDD:225201	74/241 (31%)
		WD40 repeat	1198..1236	CDD:293791	9/37 (24%)
		WD40 repeat	1241..1278	CDD:293791	12/41 (29%)
		WD40 repeat	1285..1316	CDD:293791	15/31 (48%)
		WD40 repeat	1322..1352	CDD:293791	13/29 (45%)
dcaf-1	NP_501725.2	LisH	850..883	CDD:128913	14/33 (42%)
		WD40	<1076..1329	CDD:225201	81/266 (30%)
		WD40 repeat	1133..1168	CDD:293791	9/34 (26%)
		WD40 repeat	1175..1205	CDD:293791	9/29 (31%)
		WD40 repeat	1213..1252	CDD:293791	18/38 (47%)
		WD40 repeat	1258..1295	CDD:293791	16/36 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160403
Domainoid	1	1.000	627	1.000	Domainoid score	I82
eggNOG	1	0.900	-	-		E1_KOG1832
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8805
Inparanoid	1	1.050	627	1.000	Inparanoid score	I469
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48874
OrthoDB	1	1.010	-	-		D105679at2759
OrthoFinder	1	1.000	-	-		FOG0006308
OrthoInspector	1	1.000	-	-		oto19779
orthoMCL	1	0.900	-	-		OOG6_104588
Panther	1	1.100	-	-	LDO	PTHR13129
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2475
SonicParanoid	1	1.000	-	-		X5678
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800