DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mahj and dcaf1

DIOPT Version :9

Sequence 1:	NP_001246451.1	Gene:	mahj / 37462	FlyBaseID:	FBgn0034641	Length:	1544	Species:	Drosophila melanogaster
Sequence 2:	XP_002935666.2	Gene:	dcaf1 / 100495749	XenbaseID:	XB-GENE-6050928	Length:	1498	Species:	Xenopus tropicalis

Alignment Length:	1546	Identity:	585/1546 - (37%)
Similarity:	851/1546 - (55%)	Gaps:	180/1546 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 TKKELTQIIDKWEQQQTQNGYDPVPTLRSLAEIFEREKDVYRRKDPDPLDSRHPYRADPSCQYGL 173
            :|.|||.::::||... .:|:|.||.|..::|:.|:|.:.||:.||||.|.|||.||:|.|..|.
Frog    10 SKSELTTMLEQWESGH-GSGHDMVPVLTRMSELIEKETEEYRKGDPDPFDDRHPGRANPECMLGH 73

  Fly   174 LLKLLFRKDTFMGKLLNDYLRENYFSRQNVSRSSLELNILACRLILEIMPGMETSAVFQTAEGDG 238
            ||::||:.|.||..|:|.|:.        .||.. .||..||||:|:||||:||:.|||  |.:|
Frog    74 LLRILFKNDDFMNALVNAYVM--------TSREP-PLNTAACRLLLDIMPGLETAVVFQ--EKEG 127

  Fly   239 TINRIYSWAEDSIEPLQSYATGLLAEAMEVSDIAINFRDLNIRLVPKMIKRLHMLLAISKSATSD 303
            .:..::.||.::.:||::||||||..|||..|||.|:||.|.::|..::.||..|.:...|...:
Frog   128 IVENLFKWAREAEQPLRTYATGLLGGAMENQDIAANYRDENSQMVALVLSRLRELQSQDASCKQE 192

  Fly   304 VN-------TSMHNLSADSSTAGMLSWVACASNASAP--QSPQHN-----------GSGLGASSS 348
            :.       .|...|..|.....|       .....|  ..|:|:           |.|:..:|.
Frog   193 MKRQSPRRPLSEPLLPLDEEAVDM-------DYGETPLDTGPKHDEVVSFRLESSPGYGVMVNSG 250

  Fly   349 QHGDASNMSILFENSRD-----AFS----------------VSRYYKRMYIPLHPATADTSQMLI 392
            ..|.||...:..|..|.     :||                :|.:.......|.|.|....|.||
Frog   251 GTGPASRKKLDTEAHRKVKHKLSFSEPERASSELSNSSWSEMSPWVIGTNYSLCPLTPAIEQRLI 315

  Fly   393 MRFLTSLGEYQEFLAMAFENNVMQLIFGYLENLDRRDTCLAYEVLKYLASLLCHKKFALEFISHG 457
            :::||.||||||.|.:..:....:|:..|::.....|..|.:|.||:|||||.|.|||.||::||
Frog   316 LQYLTPLGEYQELLPIFMQMRSRELMMYYIDLKRTNDVLLTFEALKHLASLLLHNKFAAEFVAHG 380

  Fly   458 GLELLLKVPRPSLATTGVSIAIYYLAYCEDAMERICSMQRPLISELVRYALWILGRCHDSSKCHA 522
            |::.||::||||:|.||||:.:|||:|.:|||||:|.....::.::|.|.||::...|.|..|||
Frog   381 GVQKLLEIPRPSMAATGVSMCLYYLSYNQDAMERVCMHPHKVLKDVVNYTLWLMECSHASGCCHA 445

  Fly   523 TMFFSLSFQFKVILDEFDAQDGLRKLYNVISVLKILDPSHNDSDNDSDFNEDVECASRQMVRHVC 587
            |||||:.|.|:.:|:.||:|||||:|.|:||.|:||    |..|..:..::|...||||..:|.|
Frog   446 TMFFSICFSFRAVLELFDSQDGLRRLVNLISTLEIL----NLEDQGALLSDDEIFASRQTGKHTC 506

  Fly   588 VALKRYMEAHFFYKYNSF---LCQTNAA---SPAPSSAHYFNQNPTVAAKLTFDQLNDQIRTLQE 646
            :||:||.|||...|....   |.:|...   .|.|         |..|...|.:|:.:.:..|.|
Frog   507 MALRRYFEAHLAIKVEQVKQALQRTEGGLPIHPPP---------PYKACSYTREQIVEMMEYLIE 562

  Fly   647 HTSIRAHWQPVDQLMKLGGITMLLRIIAFSYDW-VNSGRSETVRSALDVLSVCCIIPRVYVVLCE 710
            ....:.:|:|.:..:||..:.:||::|:.:..| ....|::|||.|||||::..::|::.:.|.|
Frog   563 FGPAQLYWEPAEVFLKLSCVQLLLQLISIACTWKTYYARNDTVRYALDVLAILTVVPKIQLQLSE 627

  Fly   711 RLLMLDK----TTTSGFCSVLGAAAGE-ISSDAEVIKSALAVLCHCVCSPIIRKDSGTSLIKFGT 770
            .:.:||:    .:|.|...||..|.|| .:.|||:.||||.::.:|||:|..|..|....:. ||
Frog   628 PVDVLDEAGSTVSTVGMSIVLCVAEGEFFTHDAEIQKSALQIIINCVCAPETRVSSIGKYVS-GT 691

  Fly   771 SSRKNKA-----NHKYAEELIERVWESVCSNNGIVVLLSLMQTKGPITDADCIRGMACRALAGLA 830
            ..|:...     :|...|..:.::|..|.|||||.|||||:..|.||||||.||.:||:||.||:
Frog   692 PRRRGLVCPTFHHHGRGEPTLSKMWNVVQSNNGIKVLLSLLSVKMPITDADQIRALACKALVGLS 756

  Fly   831 RSDRVRQIVSKLPLFASGQLQTLMRDPILQEKRAEHVIFQKYALELLERVSGKTKPLNNPLDPSL 895
            ||..||||:||||||:|.|:|.||::||||:||:|||.|.|||.||:|||||  |||....|.||
Frog   757 RSTSVRQIISKLPLFSSSQIQQLMKEPILQDKRSEHVRFCKYAAELIERVSG--KPLLMGSDVSL 819

  Fly   896 SNMHKANVIAQTRIQYNKQQLYQLIFEHLESNGLSQTAQMLQREVGLPLQTPTTRSFHQS---PF 957
            :.:.||:|:||:||.:.:::|..||..||.|.||.:|...|.||..||:    |.:.|.|   |.
Frog   820 ARLQKADVVAQSRITFPEKELLLLIRNHLVSKGLQETVATLTREADLPM----TAALHSSTYLPA 880

  Fly   958 DYKSLPSGSS--SLSRN-RLRSRMQDVNAAIMGNGDLNRSFGED--SSPAGAGGSNAGDGVSIPN 1017
            .....|:.||  ||.|. |:.:|:.  :.|:..:...:|.....  ||||..   :.|..: |..
Frog   881 TATQPPTTSSPVSLPRTPRIPARLS--STALCPHPPSSRPQLPPPLSSPAPV---STGSPL-IGR 939

  Fly  1018 FSSLNTTQTPIKIRRTDRSSVSRSIQKQAMEPGGMSVGLAEDGQLH---PKRITLNTIVTEYLTN 1079
            .|.....|:|...:|       ..:.:|..:.|..|...|...|:.   |...||::|:||||..
Frog   940 ISFARERQSPCNGKR-------GRVLRQKSDHGAYSQSPAFRKQMERHVPSPPTLDSIMTEYLRE 997

  Fly  1080 QHSLCNNPVTTCPQFDLYEPHKCPDPKPSRLLSSNYNLTSRHARTQA-----GFNTSRFDRRYVH 1139
            ||:.|.|||..||.|.|:.||:||:||..|  .:..|.|||..|..|     |.:...|||..:.
Frog   998 QHARCKNPVAICPPFSLFTPHQCPEPKQRR--QAPTNCTSRLTRRAAFPKYGGVDGGCFDRHLIF 1060

  Fly  1140 THFSPWRSIRSADYEDLEFTCCDLAG--KYIIVGTQQGDGRVFNMNDGVEQFFSNCHNFSVDAIK 1202
            :.|.|....|..:.::..||||..:.  :::::||..|..:::|:..|.|:...|||..::..::
Frog  1061 SRFRPISVFRETNEDESGFTCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHISAITHLE 1125

  Fly  1203 ANRAGDLVITSSFWRTPTSILWSIADDEFKLKLRLPDVTYCEFSQTVQDRLLGTQNECATLFDIN 1267
            .:|.|.|::|::.|..|.|.|||: ...|::|....:..|.|||:..|||::||:.:.|.::||.
Frog  1126 PSRDGSLLLTAATWSQPLSALWSM-KSVFEMKHSFTEDHYVEFSKLSQDRVIGTKEDVAHIYDIQ 1189

  Fly  1268 TGSKVAS-FTPTIPNLYTKNRATLCRTDELILSDGVLWDVRSGKEIHKFDKFNQCISGVFHPNCL 1331
            ||.|:.: :...:.|.|.:|.||...||:|:|:|||||||||.:.||||||||..||||||||.|
Frog  1190 TGQKLLTLYNSDLANNYKRNCATFNPTDDLVLNDGVLWDVRSAQAIHKFDKFNMNISGVFHPNAL 1254

  Fly  1332 EIIANTEVWDLRTFHLLQTVPVLDQRNCTFSPM-HVIYGASLGADRDHDM----ETTTYDTSFNV 1391
            |:|.|||:|||||||||.|||.|||....|:.. .|:|||.|.||.:.|:    ..:.:.:||..
Frog  1255 EVIVNTEIWDLRTFHLLHTVPALDQCRVVFNNTGTVMYGAMLQADDEDDLLEERMKSPFGSSFRT 1319

  Fly  1392 LDAYDYSSIATIDVKRNINDLSVSANGSLIAVVEDYSGYES-KQETYVKIYAVGVKK-SERSEEE 1454
            .:|.||..||||||||||.||........:||:|:....:: ..:|..::|.||.:: :|..:||
Frog  1320 FNATDYKPIATIDVKRNIFDLCTDTKDCYLAVIENQGTMDALNMDTVCRLYEVGRQRLAEDEDEE 1384

  Fly  1455 DDEEVPESDEDGSDTGSENTFAIGQNLLGFPLLRNLHGSDNDDEDLDEDDDDGE----------- 1508
            :|:|..|.:::..|...:::..:|      |||         |.:|:|:::.||
Frog  1385 EDQEEEEQEDEEDDDDDDDSDDLG------PLL---------DAELEEEEETGEQAGEDGENDFS 1434

  Fly  1509 PLDS-------DDDSDDDDGSDNGDDDG---DFDV-----LEYFDRSSSDD 1544
            |.|.       :||.||.|..|.||:||   |.|:     |...|..|||:
Frog  1435 PSDDEELANLLEDDEDDGDDGDEGDEDGHDEDSDIDPEVELILGDSDSSDN 1485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mahj	NP_001246451.1	LisH	912..944	CDD:128913	13/31 (42%)
		WD40	1159..>1350	CDD:295369	88/193 (46%)
		WD40 repeat	1159..1192	CDD:293791	9/34 (26%)
		WD40	1194..>1423	CDD:225201	109/234 (47%)
		WD40 repeat	1198..1236	CDD:293791	12/37 (32%)
		WD40 repeat	1241..1278	CDD:293791	15/37 (41%)
		WD40 repeat	1285..1316	CDD:293791	19/30 (63%)
		WD40 repeat	1322..1352	CDD:293791	24/29 (83%)
dcaf1	XP_002935666.2	WD40	1080..1294	CDD:421866	97/214 (45%)
		WD40 repeat	1080..1115	CDD:293791	9/34 (26%)
		WD40 repeat	1121..1160	CDD:293791	12/39 (31%)
		WD40 repeat	1165..1201	CDD:293791	14/35 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	898	1.000	Domainoid score	I55
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H8805
Inparanoid	1	1.050	902	1.000	Inparanoid score	I373
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D105679at2759
OrthoFinder	1	1.000	-	-		FOG0006308
OrthoInspector	1	1.000	-	-		oto103170
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5678
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060