Protein Alignment PTP-ER and PTP3

DIOPT Version :9

• Sequence 1: NP_726092.1
• Gene: PTP-ER / 37461
• FlyBaseID: FBgn0016641
• Length: 1377
• Species: Drosophila melanogaster
• Sequence 2: NP_010998.2
• Gene: PTP3 / 856807
• SGDID: S000000877
• Length: 928
• Species: Saccharomyces cerevisiae
• Alignment Length: 1279
• Identity: 249/1279 - (19%)
• Similarity: 416/1279 - (32%)
• Gaps: 474/1279 - (37%)

  Fly   171 KSEHNSPTILFKDESSTTPGLEASRLSYSPKLLSSINNLNVSGSPLNIINSAGYKNGNFFRFPEI 235
            |...:.|:||..|.:|.        ||.:..|:.|.:::....:|:|..:::  .|.|.:..|:.
Yeast     2 KDSVDCPSILPTDRTSV--------LSETSTLVGSSSHVYSRHAPMNSYHNS--MNSNIYHSPKA 56

  Fly   236 DH-VVQDAPMDTVCLEEATRRDRSPALA--EPPEQQQQKSEGRKNRKNKNNLTIRITDVPIKNSS 297
            .. :|.......|.|:.||    :|.|.  :|.||:..|.:|          ...||.|
Yeast    57 SSPLVSYKTSSPVLLKRAT----APVLPSFKPKEQRYNKPQG----------CSLITAV------ 101

  Fly   298 QPSPLPKPKTPTIKSTKEKARSLDSAANESELSIVVHNITESHGSCDDMETGQSQPSTSVIHHHL 362
                             |..:.:::..:|..|.:.|...||.              :.|:|.:.:
Yeast   102 -----------------ELGKIIETLPDEKVLLLDVRPFTEH--------------AKSIITNSI 135

  Fly   363 HLQQPASAIHSTSLSRLDSHLSLANQRRTPRRKSP-----GINTTDWLMYHRKQNPYQVQPTHCS 422
            |:..|     ||.|.|.:...|......||..:|.     .|:....::|
Yeast   136 HVCLP-----STLLRRKNFTFSKLLDNLTPSEQSVLKSKLAIDNLRIIIY--------------- 180

  Fly   423 STTQSSLDSDASLTPSLG--------DFELKSACSV--DGGSKFGIGASLAPRSAHKHNQLLHSS 477
            .:|.:..:|..|| |..|        |..:|...|:  .|..:|               ::|...
Yeast   181 DSTANQTESSVSL-PCYGIASKLIEFDTNVKKTVSILMCGFPQF---------------KILFPD 229

  Fly   478 STNLKTL-PECLTLVEFSSSGGGPKESPFKQKSMDLPMPTLQAKTTVSTSSMNLLQRRGSNHSLT 541
            ..|..|. .:|::..|..|    ||.:  ...|:....|.:.|.|.:|:..|||..:...
Yeast   230 HINTNTFNSDCISSAEPKS----PKTN--LMNSLHNTAPHMTATTPLSSPQMNLKLKVPD----- 283

  Fly   542 LNLHSSCGNLMNSGLSHSNYSLGSILNSKSSCNLDAGTASQIRADQLPQSHLLGSSQGSRQGLFR 606
                       :|...|||:|     :|.|..|:            |..|.:..||..|  .||:
Yeast   284 -----------DSRSDHSNFS-----SSPSPRNV------------LSDSPMSSSSPIS--ALFK 318

  Fly   607 RRGSNHSITLKTGHTTTSCGDLNSMQQLQQQQAMLSAEKY-NRLNMRTNSTGSGSGSGSNVPTPK 670
                   ..|....|     ::|.|.:..|.:.::..|.| :.:|::...
Yeast   319 -------FQLPAPQT-----NINQMFKFSQNEEIMGLETYLSAVNIKEEH--------------- 356

  Fly   671 RGLLERRGSNQSLTLNMGSILGGAAGTEIQMTDIVQPKVTVCSCAAANQAPHQRKFFSTENLNSS 735
                ||..:|.|                                  |.::....:|...:|....
Yeast   357 ----ERWYNNDS----------------------------------AKKSLQNFQFPKNQNSLEK 383

  Fly   736 KANSQKFFGQVCFGSASDLQPNPQQDSVREDQAIGATCTCAGTVRNIMTRPLSPQTTSEEFKIYL 800
            ..|..|...|:.:   .:|..|.:::.:  |..|                        .|:..:|
Yeast   384 DTNKDKLGFQIRY---ENLSKNYEKEVI--DSVI------------------------PEWFQHL 419

  Fly   801 ASIQMLQSASNPLNQFDLI---RLNYVFDHSYQTNRNIIEQPPVLGSNARDVETPTDMVPPSSED 862
            .||..::..|. ..:.|.:   |||:......:.|..|:|:|...........:.| ::||...|
Yeast   420 MSIPKIELVSQ-FQKLDFLEKRRLNHSVSFRKKENSFILEKPSSYPEQLTSTSSST-IMPPKFPD 482

  Fly   863 SELLASYQTVVSRMAQPIPELKENEQKRIFRDLHKEFWDLPL----NHQEKPMVFGS----QTKN 919
                      |:::.      |.:..:.||....|....|.|    :.:...::..|    ..||
Yeast   483 ----------VNKVQ------KRSHSQPIFTQYSKYKSMLSLESDSDSESDDVIISSGVELGAKN 531

  Fly   920 RYKTILPNENSRVLLES--ESSELTSLLGEIKRTSSVTASEDLP-YINANYIKGPDYVSK----- 976
            |||.|.|.|:|||:|:.  :||:      .||.:.|.:....|. ||||||:..|.:..:
Yeast   532 RYKDIFPYEHSRVILKKGLQSSK------GIKHSHSTSDGGILDNYINANYLSLPRFSVEQNSSF 590

  Fly   977 ----------CYVATQGPLPNTIFEFWLMIYQN-----------TQRYIRRCV---DGGSSSSPH 1017
                      .|:|||.|:|:|:.:|:..|..|           .:..|.:|.   ..|:.:..|
Yeast   591 QTTTTTTRRVRYIATQAPMPSTVHDFYTCILNNGVPLVLSLTNDFENGIEKCYRYWQEGNYNGIH 655

  Fly  1018 VDREQILQQYFQKIVMLTNFTEANR-----QKCAVYFPIELNEIFAVAAKCEVFQLSAAARDYFD 1077
            |   ::|:   :||:.:.:.|...:     |..::|                    ||..:....
Yeast   656 V---KLLE---KKILKMPSTTSMRKNTMGTQNSSLY--------------------SAGVQGNSS 694

  Fly  1078 RYLTPTFVPDTVVASSDAIDYEISGRHIGVESVKVTL------EGDLLEALPAQGSFFLIKNVGI 1136
            .|.|           .:..|.:.:..:....::.||.      :.|..:|:
Yeast   695 NYST-----------DNDNDNDNNNNNNNNSNIAVTAAACDDDDDDDDDAI-------------- 734

  Fly  1137 VRRNGYSVRKLVLLYCIRVPQSASYHLQKIYCYHYWYPDWPDHHSPRDINTLLD--TCLHVLNLG 1199
                  .:||::|.|   ..|...|.|.:|.     ..:||      |:.|||:  :.|..:|:.
Yeast   735 ------LIRKILLTY---HDQEKPYELLQIQ-----VKNWP------DLGTLLNPISILQAINVK 779

  Fly  1200 KCESEFDIYDDTRSERNAHLAAQRLEIYQQDIFNAVQPLPVIHCSAGIGRTGCFTAILNAVRQLR 1264
                  :...||...||         .||.|..    |..::|||||.||||....|.:.:..
Yeast   780 ------NHIIDTLFARN---------YYQNDQL----PTILVHCSAGCGRTGTLCTIDSILSN-- 823

  Fly  1265 QSLAYSLTGMLTKSLTSSSTEEYHNPTDSDSSFTCNTIRHISHILDHRDAEAVKTPPSFDRLPKM 1329
                :.:..||.|                                     |.||.        |.
Yeast   824 ----FEMFEMLQK-------------------------------------EFVKL--------KY 839

  Fly  1330 PDIFVDVLGIVCNL-RLQRGGMVQNSEQYELIHRAICLYLKRTL 1372
            |....|.:....|: |.||..||||..|:..|:..:..|.:..|
Yeast   840 PAKLFDPISWTINIFRKQRISMVQNINQFIFIYDCLLFYFRLRL 883

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	Y_phosphatase	916..1364	CDD:278528	108/493 (22%)
		PTPc	917..1364	CDD:238006	108/492 (22%)
PTP3	NP_010998.2	DSP_MapKP	97..231	CDD:238723	35/206 (17%)
		PTP_fungal	571..873	CDD:350509	90/442 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I2978
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19134
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.000