Protein Alignment PTP-ER and PTP2

DIOPT Version :10

• Sequence 1: NP_726092.1
• Gene: PTP-ER / 37461
• FlyBaseID: FBgn0016641
• Length: 1377
• Species: Drosophila melanogaster
• Sequence 2: NP_014851.3
• Gene: PTP2 / 854383
• SGDID: S000005734
• Length: 750
• Species: Saccharomyces cerevisiae
• Alignment Length: 991
• Identity: 204/991 - (20%)
• Similarity: 304/991 - (30%)
• Gaps: 415/991 - (41%)

  Fly   500 PKESP-FKQKSMDLP-MPTLQAKTTVSTSSMNLLQRRGSNHSLTLNLHSSCGNLMNSGLSHSNYS 562
            |.:.| ::.::::|. :|..|.|.......:|:.:...:.||..|.|....|...||.|.::|..
Yeast    39 PGQMPVYRGETINLSNLPQNQIKPCKDLDDVNIRRNNSNRHSKILLLDLCAGPNTNSFLGNTNAK 103

  Fly   563 LGSILNSKSSCNLDAGTASQIRADQLPQSHLLGSSQGSRQG--------------LFRRRGSNHS 613
            ..::|:......|       ::....|..:||.:..||.:.              :|....|..|
Yeast   104 DITVLSLPLPSTL-------VKRSNYPFENLLKNYLGSDEKYIEFTKIIKDYDIFIFSDSFSRIS 161

  Fly   614 ITLKTGHTTTSC------------------------GDLNSMQQLQQQQAMLSAEKYN------R 648
            ..||    ||.|                        |.||     ..:...|...|.|      .
Yeast   162 SCLK----TTFCLIEKFKKFICHFFPSPYLKFFLLEGSLN-----DSKAPSLGKNKKNCILPKLD 217

  Fly   649 LNMRTNSTG-SGSGSGSNVPTPKRGLLERRGSNQSLTLNMGSILGGAAGTEIQMTDIVQPKVTVC 712
            ||:..|.|. |......|:|.|          |.|..:.:.|:          ..|::.
Yeast   218 LNLNVNLTSRSTLNLRINIPPP----------NDSNKIFLQSL----------KKDLIH------ 256

  Fly   713 SCAAANQAPHQRKFFSTENLNSSKANSQKFFGQVCFGSASDLQPNP-------QQDSVREDQAIG 770
                          :|..:|       ||||.   |...:||.||.       :..||:|::.:
Yeast   257 --------------YSPNSL-------QKFFQ---FNMPADLAPNDTILPNWLKFCSVKENEKV- 296

  Fly   771 ATCTCAGTVRNIMTRPLSPQTTSEEFKIYLASIQMLQSASNPLNQFDLIRLNYVFDHSYQTNRNI 835
                       |:.:..:...|.|.|::.... :.|:....||:|..|          .|..|.
Yeast   297 -----------ILKKLFNNFETLENFEMQRLE-KCLKFKKKPLHQKQL----------SQKQRG- 338

  Fly   836 IEQPPVLGSNARDVETPTDMVPPSSEDSELLASYQTVVSRMAQPIPELKENEQKRIFRDL----- 895
                                 |.|::||:|    .::.|...|....||.|.||.....|
Yeast   339 ---------------------PQSTDDSKL----YSLTSLQRQYKSSLKSNIQKNQKLKLIIPKN 378

  Fly   896 ----------HKEFWDLPLNHQEKPMVFGSQTKNRYKTILPNENSRVLLE--------SESSELT 942
                      ..:....|:|..|......|.|||||..|||.|:|||.|.        ||:|
Yeast   379 NTSSSPSPLSSDDTIMSPINDYELTEGIQSFTKNRYSNILPYEHSRVKLPHSPKPPAVSEAS--- 440

  Fly   943 SLLGEIKRTSSVTASEDLP---------------YINANYIK----GPDYVSKCYVATQGPLPNT 988
                    |:.....:..|               ||||||:|    .||:.   |:|||.|||:|
Yeast   441 --------TTETKTDKSYPMCPVDAKNHSCKPNDYINANYLKLTQINPDFK---YIATQAPLPST 494

  Fly   989 IFEFWLMIYQNTQRYIRRCVDGGSSSSPHVDREQILQQYFQKIVMLTNFTEANRQKCAVYF---- 1049
            :.:||.:|..|..:.                           |:.|.:..|.|.:|..:|:
Yeast   495 MDDFWKVITLNKVKV---------------------------IISLNSDDELNLRKWDIYWNNLS 532

  Fly  1050 ----PIELNEIFAVAAK---C--EVFQLSAAARDYFDRYLTPTFVPDTVVASSDAIDYEISGRHI 1105
                .|:|...:.....   |  .|||:...|                  ..:|.|..:....|
Yeast   533 YSNHTIKLQNTWENICNINGCVLRVFQVKKTA------------------PQNDNISQDCDLPH- 578

  Fly  1106 GVESVKVTLEGDLLEALPAQGSFFLIKNVGIVRRNGYSVRKLVLLYCIRVPQSASYHLQKIYCYH 1170
                     .|||.....|....|::                             |.||
Yeast   579 ---------NGDLTSITMAVSEPFIV-----------------------------YQLQ------ 599

  Fly  1171 YWYPDWPDHHSPRDINTLLDTCLH-------------VLNLGKCESEFDIYDDTRSERNAHLAAQ 1222
              |.:|.|.... |:|.::.  ||             :.:|.|...:.|:.||..||  .||
Yeast   600 --YKNWLDSCGV-DMNDIIK--LHKVKNSLLFNPQSFITSLEKDVCKPDLIDDNNSE--LHL--- 654

  Fly  1223 RLEIYQQDIFNAVQPLPVIHCSAGIGRTGCFTAILNAVRQLRQSLAYSLTGMLTKSLTSSSTEEY 1287
                   |..|: .|| ::|||||.||||.|..:            ..|..:|:.:...|:..:.
Yeast   655 -------DTANS-SPL-LVHCSAGCGRTGVFVTL------------DFLLSILSPTTNHSNKIDV 698

  Fly  1288 HNPTDSDSSFTCNTIRHISHILDHRDAEAVKTPPSFDRLPKMPDIFVDVLGIVCN-LRLQRGGMV 1351
            .|.|.                                          |::.|:.| ||.||..||
Yeast   699 WNMTQ------------------------------------------DLIFIIVNELRKQRISMV 721

  Fly  1352 QNSEQYELIHRAICLY 1367
            ||..||...:.|:..|
Yeast   722 QNLTQYIACYEALLNY 737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	PTP_DSP_cys	919..1362	CDD:475123	109/496 (22%)
PTP2	NP_014851.3	PTP_fungal	467..732	CDD:350509	93/430 (22%)