Protein Alignment PTP-ER and ptpn12

DIOPT Version :10

• Sequence 1: NP_726092.1
• Gene: PTP-ER / 37461
• FlyBaseID: FBgn0016641
• Length: 1377
• Species: Drosophila melanogaster
• Sequence 2: NP_001025666.1
• Gene: ptpn12 / 595058
• XenbaseID: XB-GENE-942122
• Length: 696
• Species: Xenopus tropicalis
• Alignment Length: 546
• Identity: 122/546 - (22%)
• Similarity: 176/546 - (32%)
• Gaps: 257/546 - (47%)

  Fly   836 IEQPPVLGSNARDVETPTDMVPPSSEDS---------ELLASYQTVVSRMAQPIPELKENEQKRI 891
            ::|..:|.|..:.|:| .|:...:.||:         .|...|:|  .::...|...||...|
 Frog     1 MDQVAILKSFIQRVQT-MDIKDQNGEDNFGCDFMKLRRLSTKYRT--DKIYPTITGEKEENVK-- 60

  Fly   892 FRDLHKEFWDLPLNHQEKPMVFGSQTKNRYKTILPNENSRVLLESESSELTSLLGEIKRTSSVTA 956
                                      |||||.|||.::|||                 |.:....
 Frog    61 --------------------------KNRYKDILPFDHSRV-----------------RLALKVP 82

  Fly   957 SEDLPYINANYIKGPDYVSKCYVATQGPLPNTIFEFWLMIYQNTQRYIRRCVDGGSSSSPHVDRE 1021
            |.:..|||||:|||. :..|.|:|||||||||:.::|.||::.....
 Frog    83 SHESDYINANFIKGV-HGPKAYIATQGPLPNTVIDYWRMIWEYNVAI------------------ 128

  Fly  1022 QILQQYFQKIVMLTNFTEANRQKCAVYFPIELNEIFAVAAKCEVFQLSAAARDYFDRYLTPTFVP 1086
                     |||.....|..|:||..|:|                       :|.::  |.||.|
 Frog   129 ---------IVMACREFEMGRKKCERYYP-----------------------NYGEQ--TITFGP 159

  Fly  1087 DTVVASSDAIDYEISGRHIGVESVKVTLEGDLLEALPAQGSFFLIKNVGIVRRNGYSVRKLVLLY 1151
                            .||..||.:                          .|..|.||.|:|.:
 Frog   160 ----------------FHISCESEE--------------------------SRKDYFVRTLLLEF 182

  Fly  1152 CIRVPQSASYHLQKIYCYHYWYPDWPDHHSPRDINTLLDTCLHVLNLGKCESEFDIYDDTRSERN 1216
                    ....:.|:.:|  |.:||||..|...:::||    ::.|.:   .:..:||.
 Frog   183 --------QNETRTIHQFH--YVNWPDHDVPSSFDSILD----MIGLMR---HYQAHDDV----- 225

  Fly  1217 AHLAAQRLEIYQQDIFNAVQPLPVIHCSAGIGRTGCFTAILNAVRQLRQSLAYSLTGMLTKSLTS 1281
                                || .||||||.||||...||
 Frog   226 --------------------PL-CIHCSAGCGRTGAICAI------------------------- 244

  Fly  1282 SSTEEYHNPTDSDSSFTCNTIRHISHILDHRDAEAVKTPPSFDRLPKMPDIFVDVLGIVCNLRLQ 1346
                          .:|.|.::            |.:.|..|           :|..::..:|.|
 Frog   245 --------------DYTWNLLK------------AGRIPEEF-----------NVYSLIQEMRTQ 272

  Fly  1347 RGGMVQNSEQYELIHRAICLYLKRTL 1372
            |...||..|||||:||||....::.|
 Frog   273 RHSAVQTKEQYELVHRAIAQLFQKQL 298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	PTP_DSP_cys	919..1362	CDD:475123	101/442 (23%)
ptpn12	NP_001025666.1	PTPc-N12	2..298	CDD:350452	121/543 (22%)