DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTP-ER and PTPRR

DIOPT Version :9

Sequence 1:	NP_726092.1	Gene:	PTP-ER / 37461	FlyBaseID:	FBgn0016641	Length:	1377	Species:	Drosophila melanogaster
Sequence 2:	NP_002840.2	Gene:	PTPRR / 5801	HGNCID:	9680	Length:	657	Species:	Homo sapiens

Alignment Length:	1004	Identity:	215/1004 - (21%)
Similarity:	299/1004 - (29%)	Gaps:	498/1004 - (49%)

- Green bases have known domain annotations that are detailed below.

  Fly   462 LAPRSAHKHNQLLHSSSTNLKTLPECLTLVEFSSSGGGPKESPFKQKSMD-----LPMPTLQAKT 521
            :||:..::|:  .||||....:....:....|......|..:.......|     ||:|.  |..
Human    56 IAPQKIYRHS--YHSSSEAQVSKRHQIVNSAFPRPAYDPSLNLLAMDGQDLEVENLPIPA--ANV 116

  Fly   522 TVSTSSMNLLQRRGSNHSLTLNLHSSCGNLMNSGLSHSNYSLGSILNSKSSCNLDAGTASQIR-- 584
            .|.|..|::     :..::||......|.....||......:..::..|:|..|.....::..
Human   117 IVVTLQMDV-----NKLNITLLRIFRQGVAAALGLLPQQVHINRLIGKKNSIELFVSPINRKTGI 176

  Fly   585 ADQLPQSHLLGS------------------------SQG--------SRQGLF------------ 605
            :|.||...:|.|                        .||        |::|.:
Human   177 SDALPSEEVLRSLNINVLHQSLSQFGITEVSPEKNVLQGQHEADKIWSKEGFYAVVIFLSIFVII 241

  Fly   606 -------------------RRRGSNHSITL------------KTGHTTTSCGDLNSMQQLQQQQA 639
                               :.:..|..|.|            ||.|         ||.|.:|...
Human   242 VTCLMILYRLKERFQLSLRQDKEKNQEIHLSPITLQPALSEAKTVH---------SMVQPEQAPK 297

  Fly   640 MLSAEKYNRLNMRTNSTGSG------SGSGSNVPTPKR----GLLERRGSNQSLTLNMGSILGGA 694
            :        ||:..:..|.|      :.:.|..|:|.:    ||.||||||.||||:|.| ||.
Human   298 V--------LNVVVDPQGRGAPEIKATTATSVCPSPFKMKPIGLQERRGSNVSLTLDMSS-LGN- 352

  Fly   695 AGTEIQMTDIVQPKVTVCSCAAANQAPHQRKFFSTENLNSSKANSQKFFGQVCFGSASDLQPNPQ 759
                      ::|.|::                                            |.|:
Human   353 ----------IEPFVSI--------------------------------------------PTPR 363

  Fly   760 QDSVREDQAIGATCTCAGTVRNIMTRPLSPQTTSEEFKIYLASIQMLQSASNPLNQFDLIRLNYV 824
            :.                                       .:::.|||||..|.:..|
Human   364 EK---------------------------------------VAMEYLQSASRILTRSQL------ 383

  Fly   825 FDHSYQTNRNIIEQPPVLGSNARDVETPTDMVPPSSEDSELLASYQTVVSRMAQPIPELKENEQK 889
                    |:::....:|.|..  :|.|.:.|.|
Human   384 --------RDVVASSHLLQSEF--MEIPMNFVDP------------------------------- 407

  Fly   890 RIFRDLHKEFWDLPLNHQEKPMVFGSQTKNRYKTILPNENSRVLLESESSELTSLLGEIKRTSSV 954
                   ||. |:|.:          .|||||||||||..|||.|               |..:|
Human   408 -------KEI-DIPRH----------GTKNRYKTILPNPLSRVCL---------------RPKNV 439

  Fly   955 TASEDLPYINANYIKGPDYVSKCYVATQGPLPNTIFEFWLMIYQNTQRYIRRCVDGGSSSSPHVD 1019
            |.|.. .|||||||:|.....|.::|||||:.||:.:||.|::|              ..||
Human   440 TDSLS-TYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVWQ--------------EDSP--- 486

  Fly  1020 REQILQQYFQKIVMLTNFTEANRQKCAVYFPIELNEIFAVAAKCEVFQLSAAARDYFDRYLTPTF 1084
                      .|||:|...|.| :||.:|:|    |...:..|.||..:|....|
Human   487 ----------VIVMITKLKEKN-EKCVLYWP----EKRGIYGKVEVLVISVNECD---------- 526

  Fly  1085 VPDTVVASSDAIDYEISGRHIGVESVKVTLEGDLLEALPAQGSFFLIKNVGIVRRNGYSVRKLVL 1149
                                                                    .|::|.|||
Human   527 --------------------------------------------------------NYTIRNLVL 535

  Fly  1150 LYCIRVPQSASYHLQKIYCYHYWYPDWPDHHSPRDINTLLDTCLHVLNLGKCESEFDIYDDTRSE 1214
                    ....|.|.:  .||||..||||.:|.....||...|            |:.:|
Human   536 --------KQGSHTQHV--KHYWYTSWPDHKTPDSAQPLLQLML------------DVEED---- 574

  Fly  1215 RNAHLAAQRLEIYQQDIFNAVQPLPVIHCSAGIGRTGCFTAILNAVRQLRQSLAYSLTGMLTKSL 1279
               .||:|           ...|: |:||||||||||||.|.....:||::
Human   575 ---RLASQ-----------GRGPV-VVHCSAGIGRTGCFIATSIGCQQLKE-------------- 610

  Fly  1280 TSSSTEEYHNPTDSDSSFTCNTIRHISHILDHRDAEAVKTPPSFDRLPKMPDIFVDVLGIVCNLR 1344
                                               |.|                ||.|.|||.||
Human   611 -----------------------------------EGV----------------VDALSIVCQLR 624

  Fly  1345 LQRGGMVQNSEQYELIHRAICLYLKRTLA 1373
            :.||||||.|||||.:|.|:|||..|..|
Human   625 MDRGGMVQTSEQYEFVHHALCLYESRLSA 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	Y_phosphatase	916..1364	CDD:278528	120/447 (27%)
PTP-ER	NP_726092.1	PTPc	917..1364	CDD:238006	120/446 (27%)
PTPRR	NP_002840.2	PTPc	392..644	CDD:214550	130/522 (25%)
PTPRR	NP_002840.2	PTPc	417..644	CDD:238006	120/446 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	220	1.000	Inparanoid score	I3565
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.910