Protein Alignment PTP-ER and PTPN12

DIOPT Version :9

• Sequence 1: NP_726092.1
• Gene: PTP-ER / 37461
• FlyBaseID: FBgn0016641
• Length: 1377
• Species: Drosophila melanogaster
• Sequence 2: NP_002826.3
• Gene: PTPN12 / 5782
• HGNCID: 9645
• Length: 780
• Species: Homo sapiens
• Alignment Length: 527
• Identity: 124/527 - (23%)
• Similarity: 177/527 - (33%)
• Gaps: 241/527 - (45%)

  Fly   861 EDSELLASYQTVVSRMAQPIPELKENEQKRIFRD------LHKEFWDLPLNHQEK--PMVFGSQ- 916
            |..|:|..:...|..|..|    ..|.:....||      |..::      ..||  |...|.:
Human     2 EQVEILRKFIQRVQAMKSP----DHNGEDNFARDFMRLRRLSTKY------RTEKIYPTATGEKE 56

  Fly   917 ---TKNRYKTILPNENSRVLLESESSELTSLLGEIKRTSSVTASEDLPYINANYIKGPDYVSKCY 978
               .|||||.|||.::|||.|..:                 |.|:|..|||||:|||. |..|.|
Human    57 ENVKKNRYKDILPFDHSRVKLTLK-----------------TPSQDSDYINANFIKGV-YGPKAY 103

  Fly   979 VATQGPLPNTIFEFWLMIYQNTQRYIRRCVDGGSSSSPHVDREQILQQYFQKIVMLTNFTEANRQ 1043
            |||||||.||:.:||.||::..                           ...|||.....|..|:
Human   104 VATQGPLANTVIDFWRMIWEYN---------------------------VVIIVMACREFEMGRK 141

  Fly  1044 KCAVYFPIELNEIFAVAAKCEVFQLSAAARDYFDRYLTPTFVPDTVVASSDAIDYEISGRHIGVE 1108
            ||..|:|:                       |.:..:  ||.|
Human   142 KCERYWPL-----------------------YGEDPI--TFAP---------------------- 159

  Fly  1109 SVKVTLEGDLLEALPAQGSFFLIKNVGIVRRNGYSVRKLVLLYCIRVPQSASYHLQKIYCYHYWY 1173
             .|::.|.:                   ..|..|.:|.|:|.:     |:.|   :::|.:|  |
Human   160 -FKISCEDE-------------------QARTDYFIRTLLLEF-----QNES---RRLYQFH--Y 194

  Fly  1174 PDWPDHHSPRDINTLLDTCLHVLNLGKCESEFDIYDDTRSERNAHLAAQRLEIYQQDIFNAVQPL 1238
            .:||||..|...:::||    :::|                         :..||:.     :.:
Human   195 VNWPDHDVPSSFDSILD----MISL-------------------------MRKYQEH-----EDV 225

  Fly  1239 PV-IHCSAGIGRTGCFTAILNAVRQLRQSLAYSLTGMLTKSLTSSSTEEYHNPTDSDSSFTCNTI 1302
            |: ||||||.||||...||                                       .:|.|.:
Human   226 PICIHCSAGCGRTGAICAI---------------------------------------DYTWNLL 251

  Fly  1303 RHISHILDHRDAEAVKTPPSFDRLPKMPDIFVDVLGIVCNLRLQRGGMVQNSEQYELIHRAICLY 1367
            :            |.|.|..|           :|..::..:|.||...||..|||||:||||...
Human   252 K------------AGKIPEEF-----------NVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQL 293

  Fly  1368 LKRTLAL 1374
            .::.|.|
Human   294 FEKQLQL 300

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	Y_phosphatase	916..1364	CDD:278528	106/452 (23%)
		PTPc	917..1364	CDD:238006	106/447 (24%)
PTPN12	NP_002826.3	PTPc	28..292	CDD:214550	115/487 (24%)
		PTPc	60..292	CDD:238006	108/449 (24%)
		Substrate binding. /evidence=ECO:0000305|PubMed:27134172	63..67		3/3 (100%)
		Substrate binding. /evidence=ECO:0000250	231..237		4/5 (80%)
		Interaction with TGFB1I1. /evidence=ECO:0000250	345..438
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	502..639
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	657..725
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	744..780

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900