Protein Alignment PTP-ER and PTPN2

DIOPT Version :10

• Sequence 1: NP_726092.1
• Gene: PTP-ER / 37461
• FlyBaseID: FBgn0016641
• Length: 1377
• Species: Drosophila melanogaster
• Sequence 2: XP_047293651.1
• Gene: PTPN2 / 5771
• HGNCID: 9650
• Length: 494
• Species: Homo sapiens
• Alignment Length: 577
• Identity: 113/577 - (19%)
• Similarity: 188/577 - (32%)
• Gaps: 217/577 - (37%)

  Fly   802 SIQMLQSASNPLNQFDLIRLNYVFDHSYQTNRNIIEQ-------PPVLGSNARDVETPTDMVPPS 859
            |:::|.|::.|::........:...|. |..:.|..|       |.::.::...|..|..  ||.
Human     6 SLELLSSSNPPVSASQEAGTTHAHHHP-QLIKKIFWQSWCLTVLPRLVSNSYPQVILPAG--PPK 67

  Fly   860 SEDSELLASYQTVVSRMAQPIPELKENEQKRIFR-------DLHKEFWDLPLNHQEKPMVFGSQT 917
            :...:..|.|..|...:. |:|.....:|....|       ::..|..|.|....:.|   .::.
Human    68 APGLQECAFYLAVTGWLL-PVPTPHPRQQNLCSRQAAVRTKEIRNESHDYPHRVAKFP---ENRN 128

  Fly   918 KNRYKTILPNENSRVLLESESSELTSLLGEIKRTSSVTASEDLPYINANYIKGPDYVSKCYVATQ 982
            :|||:.:.|.::|||.|::..::                     ||||:.: ..:...:.|:.||
Human   129 RNRYRDVSPYDHSRVKLQNAEND---------------------YINASLV-DIEEAQRSYILTQ 171

  Fly   983 GPLPNTIFEFWLMIYQNTQRYIRRCVDGGSSSSPHVDREQILQQYFQKIVMLTNFTEANRQKCAV 1047
            ||||||...||||::                           ||..:.:|||....|....|||.
Human   172 GPLPNTCCHFWLMVW---------------------------QQKTKAVVMLNRIVEKESVKCAQ 209

  Fly  1048 YFPIELNEIFAVAAKCEVFQLSAAARDYFDRYLTPTFVPDTVVASSDAIDYEISGRHIGVESVKV 1112
            |:|.:..|:........|..||...:.|:..:|          ...:.|:|        :|::.:
Human   210 YWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHL----------LQLENINY--------IENLWI 256

  Fly  1113 TLEGDLLEALPAQGSFFLIKNVGIVRRNGYSVRKLVLLYCIRVPQSASYHLQKIYCYHYWYPDWP 1177
            ||              :|               ||::|...|..:|.....    ..|:.|..||
Human   257 TL--------------YL---------------KLLMLDVKRSLKSGETRT----ISHFHYTTWP 288

  Fly  1178 DHHSPRDINTLLDTCLHVLNLGKCESEFDIYDDTRSERNAHLAAQRLEIYQQDIFNAVQPLPVIH 1242
            |...|....:.|:....|...|....:             |..|                  |||
Human   289 DFGVPESPASFLNFLFKVRESGSLNPD-------------HGPA------------------VIH 322

  Fly  1243 CSAGIGRTGCFTAILNAVRQLRQSLAYSLTGMLTKSLTSSSTEEYHNPTDSDSSFTCNTIRHISH 1307
            |||||||:|.|:.:                                        .||..:
Human   323 CSAGIGRSGTFSLV----------------------------------------DTCLVL----- 342

  Fly  1308 ILDHRDAEAVKTPPSFDRLPKMPDIFVDVLGIVCNLRLQRGGMVQNSEQYELIHRAI 1364
                              :.|..||  ::..::.|:|..|.|::|..:|....:.||
Human   343 ------------------MEKGDDI--NIKQVLLNMRKYRMGLIQTPDQLRFSYMAI 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	PTP_DSP_cys	919..1362	CDD:475123	87/442 (20%)
PTPN2	XP_047293651.1	PTP_DSP_cys	108..379	CDD:475123	91/469 (19%)