Protein Alignment PTP-ER and PTPN1

DIOPT Version :10

• Sequence 1: NP_726092.1
• Gene: PTP-ER / 37461
• FlyBaseID: FBgn0016641
• Length: 1377
• Species: Drosophila melanogaster
• Sequence 2: NP_002818.1
• Gene: PTPN1 / 5770
• HGNCID: 9642
• Length: 435
• Species: Homo sapiens
• Alignment Length: 492
• Identity: 92/492 - (18%)
• Similarity: 152/492 - (30%)
• Gaps: 233/492 - (47%)

  Fly   884 KENEQ-------KRIFRDLHKEFWDLPLNHQEKPMVFGSQTKNRYKTILPNENSRVLLESESSEL 941
            ||.||       ..|::|:..|..|.|....:.|.   ::.:|||:.:.|.::||:.|..|.::
Human     5 KEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPK---NKNRNRYRDVSPFDHSRIKLHQEDND- 65

  Fly   942 TSLLGEIKRTSSVTASEDLPYINANYIKGPDYVSKCYVATQGPLPNTIFEFWLMIYQNTQRYIRR 1006
                                ||||:.|| .:...:.|:.||||||||...||.|:::...|
Human    66 --------------------YINASLIK-MEEAQRSYILTQGPLPNTCGHFWEMVWEQKSR---- 105

  Fly  1007 CVDGGSSSSPHVDREQILQQYFQKIVMLTNFTEANRQKCAVYFPIELNEIFAVAAKCEVFQLSAA 1071
                                   .:|||....|....|||.|:|.:       ..|..:|:
Human   106 -----------------------GVVMLNRVMEKGSLKCAQYWPQK-------EEKEMIFE---- 136

  Fly  1072 ARDYFDRYLTPTFVPDTVVASSDAIDYEISGRHIGVESVKVTLEGDLLEALPAQGSFFLIKNVGI 1136
                           ||                    ::|:||..:.::      |::.::.:.:
Human   137 ---------------DT--------------------NLKLTLISEDIK------SYYTVRQLEL 160

  Fly  1137 VRRNGYSVRKLVLLYCIRVPQSASYHLQKIYCYHYWYPDWPDHHSPRDINTLLDTCLHVLNLGKC 1201
            ........|:::                     |:.|..|||...|....:.|:....|...|..
Human   161 ENLTTQETREIL---------------------HFHYTTWPDFGVPESPASFLNFLFKVRESGSL 204

  Fly  1202 ESEFDIYDDTRSERNAHLAAQRLEIYQQDIFNAVQPLPVIHCSAGIGRTGCF----TAILNAVRQ 1262
            ..|..                              |: |:||||||||:|.|    |.:|
Human   205 SPEHG------------------------------PV-VVHCSAGIGRSGTFCLADTCLL----- 233

  Fly  1263 LRQSLAYSLTGMLTKSLTSSSTEEYHNPTDSDSSFTCNTIRHISHILDHRDAEAVKTPPSFDRLP 1327
                                                         ::|.|     |.|.|
Human   234 ---------------------------------------------LMDKR-----KDPSS----- 243

  Fly  1328 KMPDIFVDVLGIVCNLRLQRGGMVQNSEQYELIHRAI 1364
                  ||:..::..:|..|.|::|.::|....:.|:
Human   244 ------VDIKKVLLEMRKFRMGLIQTADQLRFSYLAV 274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	PTP_DSP_cys	919..1362	CDD:475123	81/446 (18%)
PTPN1	NP_002818.1	PTPc-N1	16..292	CDD:350456	88/481 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	338..359
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	378..398