Protein Alignment PTP-ER and ca16b

DIOPT Version :10

• Sequence 1: NP_726092.1
• Gene: PTP-ER / 37461
• FlyBaseID: FBgn0016641
• Length: 1377
• Species: Drosophila melanogaster
• Sequence 2: XP_021332937.1
• Gene: ca16b / 569183
• ZFINID: ZDB-GENE-080818-1
• Length: 1382
• Species: Danio rerio
• Alignment Length: 1283
• Identity: 245/1283 - (19%)
• Similarity: 393/1283 - (30%)
• Gaps: 468/1283 - (36%)

  Fly   251 EATRRDRSPALAEPPEQQ-------------QQKSEGRKNRKN---------KNNLTIRITDVPI 293
            |...|::||.....||.|             :.||..|...||         ||:..:|...:|.
Zfish    72 ECGERNQSPVDILDPETQVSQECQELTLDGFETKSSNRTTMKNTGKTVSIVLKNDYFVRGAGLPG 136

  Fly   294 K-------------NSSQPS--PLPKPKTPTIKS----TKEKARSLDSAANE----SELSIVVHN 335
            :             |.|..|  .:...|.|....    ..:...||.:|..|    :.:::....
Zfish   137 RFKAEKVEFHWGSTNGSAGSEHSINGKKFPVEMQIYFYNSDDFDSLSTAIKERRIIAAMAVFFQV 201

  Fly   336 ITESHGSCDDMETGQSQPSTSVIHHHLHLQQPASAIHSTSLSRLDSHLSLANQRRTPRRKSPGIN 400
            .|:.:.:.:.:..|..:    |:||.......:..:.....|.|.|:........||    |...
Zfish   202 ATKDNIAAEPIIAGLKR----VVHHEKETNLGSFILRDLLPSSLGSYYRYTGSLTTP----PCSK 258

  Fly   401 TTDW--------LMYHRKQNPYQV----QPTHCSSTTQ--------SSLDS---------DA--- 433
            ..:|        |.||:.:..|.:    |..|..|...        ..|||         ||
Zfish   259 VVEWIIFSRPVYLSYHQLEAFYSIFTTEQQDHVKSVDYLRNNHRPIQDLDSRRIFKSALMDAWMP 323

  Fly   434 SLTPSLGDFELKSACSVDGGSKFGIGASLAPRSAHKHNQLLHSSSTNLKTL----PECL---TLV 491
            ....|..|.|....|                 |:...|..||..:.....|    |..:   .:|
Zfish   324 ETMASAADTETSRVC-----------------SSIPDNMKLHPLNRTALVLTWDRPSAVYHPPIV 371

  Fly   492 EFSSSGGGPK-ESPFKQKSMDLPMPTLQAKTTVSTSSMNLLQR--------RGSNHSLTL----- 542
            .|..|....| |.||::........:.:|..|:.:..:..|.|        :.|:.|.||
Zfish   372 GFLVSYSWVKDEMPFEKTFTQSSEHSTRAVITLVSPDVLYLFRVQALCQRDQRSDFSQTLLFKAN 436

  Fly   543 ---------------------------NLHSSCGNLMNSGLSHSNYSLGSILNSKSSCNLDAGTA 580
                                       .:.|......::||..|..|:.:.:...||.. .|..|
Zfish   437 TTRIFEGTRIVKTGMPTVSPASSADMAPISSGSSTWTSAGLPFSFVSMATGMGPPSSGG-QATVA 500

  Fly   581 SQIRADQLPQSHLLGSSQGSRQGLFRRRGSNHSITLKTGHTTT----------SCGDLNSMQQLQ 635
            |.:.:..|......||...|..|.|....|.::....|.|..|          |....|.:::.:
Zfish   501 SVVTSTLLAGLGFSGSVISSLPGSFWPTHSTNTGPSPTQHPATPTAENSPSEDSTDTQNKLEEEE 565

  Fly   636 QQQAMLSAEKYNRLNMRTNSTGSGSGSGSNV----------------PTPKRGLLERRGSNQSLT 684
            :.:.....|:.................|.:|                ||.|....||..: :|.|
Zfish   566 EHKKEDDEEEEEEEEEEEQRDEEKKKKGKDVTVKDKKQTVQKPTAPIPTSKHRDRERPDA-ESST 629

  Fly   685 LNMGSILGGAAGTEIQMTDIVQPKVTVCSCAAANQAPHQRKFFSTENLNSSKANSQKFFGQVCFG 749
            |....:....:|                    |.:.|...        :||||..|
Zfish   630 LTPAEVEEQVSG--------------------ATERPDAE--------DSSKATWQ--------- 657

  Fly   750 SASDLQ-PNPQQDSVR-EDQAIGATCTCAGTVRNIMTRPLSPQTTSEEFKIYLASIQMLQSASNP 812
            ..:|:| |:...:|.: .|:..........|.||.:: .:|..:.|...::......|:.||...
Zfish   658 DDNDMQIPSSSTESSKLSDEEKANWPYYINTERNSIS-TVSRDSVSSSSRMEWIIPLMVVSALTL 721

  Fly   813 LNQFDLIRLNYVFDHSYQTNRNIIEQPPVLGSNARDVETPTDMVPPSSEDSELLASYQTVVSRMA 877
            |....|:.:...:...:||....||.    .::.|.:...:..:..:::|.|.:.     |.:..
Zfish   722 LCLIMLLAVLVYWRRFFQTAHFYIED----RNSPRVIHNDSFPIISTADDLEAMP-----VRQFI 777

  Fly   878 QPIPELKENEQKRIFRDLHKEFWDLP------------LNHQEKPMVFGSQTKNRYKTILPNENS 930
            :.|.||..|.:    ....:||.::.            .||.|      ::.||||..|:..::|
Zfish   778 KHIMELHSNNR----HGFSQEFDEVQHCTSEMKITAEHSNHPE------NKHKNRYINIVAYDHS 832

  Fly   931 RVLLESESSELTSLLGEIKRTSSVTASEDLPYINANYIKGPDYV-SKCYVATQGPLPNTIFEFWL 994
            ||       :|..|.|:..:.|.        ||||||:.|  |. ::.|:|.||||.:|..:||.
Zfish   833 RV-------KLQQLPGKDSKHSD--------YINANYVDG--YKRARAYIAAQGPLKSTFEDFWR 880

  Fly   995 MIY-QNTQRYIRRCVDGGSSSSPHVDREQILQQYFQKIVMLTNFTEANRQKCAVYFPIELNEIFA 1058
            ||: |||                            ..|||:||..|..|:||..|:|.|.:|::.
Zfish   881 MIWEQNT----------------------------TVIVMITNLVEKGRRKCDQYWPSENSEVYG 917

  Fly  1059 VAAKCEVFQLSAAARDYFDRYLTPTFVPDTVVASSDAIDYEISGRHIGVESVKVTLEGDLLEALP 1123
                                                              ::.|||:...:.|..
Zfish   918 --------------------------------------------------NIMVTLKSTKVYAYY 932

  Fly  1124 AQGSFFLIKNVGIVR-RNGYSVRKLVLLYCIRVPQSASYHLQKIYCYHYWYPDWPDHHSPRDINT 1187
            .. ..|:::|..:.: :.|....:|||          .||          |..|||...|
Zfish   933 TL-RHFIVRNSKLKKGQKGRQNERLVL----------QYH----------YTQWPDMGVP----- 971

  Fly  1188 LLDTCLHVLNLGKCESEFDIYDDTRSERNAHLAAQRLEIYQQDIFNAVQPLPV-IHCSAGIGRTG 1251
              :..|.||..                           |.:..:.:|....|| :|||||:||||
Zfish   972 --EYTLPVLKF---------------------------ISRSTVTHASSTGPVLVHCSAGVGRTG 1007

  Fly  1252 CFTAILNAVRQLRQSLAYSLTGMLTKSLTSSSTEEYHNPTDSDSSFTCNTIRHISHILDHRDAEA 1316
            .:..|.:.::|::                           |..|
Zfish  1008 TYIVIDSMLKQIK---------------------------DRGS--------------------- 1024

  Fly  1317 VKTPPSFDRLPKMPDIFVDVLGIVCNLRLQRGGMVQNSEQYELIHRAI 1364
                             |:|||.:.::|.||..:||..||:..||.|:
Zfish  1025 -----------------VNVLGFLKHIREQRNYLVQTEEQFIFIHDAL 1055

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	PTP_DSP_cys	919..1362	CDD:475123	95/446 (21%)
ca16b	XP_021332937.1	alpha_CARP_receptor_like	62..314	CDD:239396	47/249 (19%)
		FN3	340..417	CDD:214495	16/76 (21%)
		PTP_DSP_cys	791..1060	CDD:475123	103/486 (21%)
		R-PTP-G-2	1144..1348	CDD:350508