DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTP-ER and csw

DIOPT Version :9

Sequence 1:	NP_726092.1	Gene:	PTP-ER / 37461	FlyBaseID:	FBgn0016641	Length:	1377	Species:	Drosophila melanogaster
Sequence 2:	NP_477131.1	Gene:	csw / 45278	FlyBaseID:	FBgn0000382	Length:	945	Species:	Drosophila melanogaster

Alignment Length:	1011	Identity:	186/1011 - (18%)
Similarity:	292/1011 - (28%)	Gaps:	444/1011 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   544 LHSSCGNLMNSGLSHSNYSLGSILNSKSSCNLDAGTA----SQIRADQLPQSHL----LGSSQGS 600
            |.||.||::|..|........:.:|:.::..|:...|    .....::..|:|.    ..|.:..
  Fly    10 LSSSLGNVVNHKLQEKQVYNNNNINNNNNNTLNNNNAYNNQRNFEYERAIQAHYGSKGRRSEERE 74

  Fly   601 RQGLFR-RRGSNHSITLKT------------------------GHTTTSCGDLNSMQQLQQQQAM 640
            |.|.|: .:|....:|..|                        |....:....|...:||:::..
  Fly    75 RSGKFKASKGRKAKVTPPTETPEAQEPACKNCMTHDELAQIIKGVAKGADAQRNRDNRLQRRRRP 139

  Fly   641 LSAEKYNRLNMRTNS------TGSGSGSGSNVP-----TPKR-----GLLERRGSNQSLTLNM-- 687
            |||:.....:..|::      |.|...|....|     ||.:     |......|..||...|
  Fly   140 LSAQPSAAASASTSTESLHRLTPSPQASYPATPTSWTATPPQFPAAFGGASCSNSTLSLLATMRV 204

  Fly   688 ---------GSILG----------GAAGTEIQMTDIVQPKVTVCSCAAANQAPH-----QRKFFS 728
                     |::.|          |..|:.:......:|...|.|....::..|     |.|.:.
  Fly   205 QLHGYTWFHGNLSGKEAEKLILERGKNGSFLVRESQSKPGDFVLSVRTDDKVTHVMIRWQDKKYD 269

  Fly   729 TENLNSSKANSQKFFGQVCFGSASDL----QPNPQQDS----VREDQAIGAT-CTCAGTVRNIMT 784
            ..             |...||:.|:|    :.||..::    |...|...|| .|.||.  |...
  Fly   270 VG-------------GGESFGTLSELIDHYKRNPMVETCGTVVHLRQPFNATRITAAGI--NARV 319

  Fly   785 RPLSPQTTSEEFKIYLASIQMLQSASNPLNQFDLIRLNY----VFDHSYQTNRNIIE-QPPVLGS 844
            ..|......|||:......:...|.:....|.:.::..|    .:||   |...::: :..|.|:
  Fly   320 EQLVKGGFWEEFESLQQDSRDTFSRNEGYKQENRLKNRYRNILPYDH---TRVKLLDVEHSVAGA 381

  Fly   845 ---NARDVETPT--DMVPPSSEDSELLASYQTVVSRMAQPIPELKENEQKRIFRDLHKEFWDLPL 904
               ||..:..||  |:...||....|.:|           :|..
  Fly   382 EYINANYIRLPTDGDLYNMSSSSESLNSS-----------VPSC--------------------- 414

  Fly   905 NHQEKPMVFGSQTKN-------RYKT---------ILPNENSRVL----------LESESS---- 939
                 |....:||:.       :.||         |||..|....          ..||||
  Fly   415 -----PACTAAQTQRNCSNCQLQNKTCVQCAVKSAILPYSNCATCSRKSDSLSKHKRSESSASSS 474

  Fly   940 ---------------------------ELTS-----LLGEIKRTSSVTASEDLPYINANYIKGPD 972
                                       .|||     |:|.:||             ::|...|..
  Fly   475 PSSGSGSGPGSSGTSGVSSVNGPGTPTNLTSGTAGCLVGLLKR-------------HSNDSSGAV 526

  Fly   973 YVS-------------KCYVATQGPL----PNTIFEFWLMIYQNTQRYIRRCVDGGSSSSPHVDR 1020
            .:|             |.|:||||.|    .||:.:||.|::|...|.
  Fly   527 SISMAEREREREREMFKTYIATQGCLLTQQVNTVTDFWNMVWQENTRV----------------- 574

  Fly  1021 EQILQQYFQKIVMLTNFTEANRQKCAVYFPIELNEIFAVAAKCEVFQLSAAARDYFDRYLTPTFV 1085
                      |||.|...|..::|||.|:|.|        .:.|.|
  Fly   575 ----------IVMTTKEYERGKEKCARYWPDE--------GRSEQF------------------- 602

  Fly  1086 PDTVVASSDAIDYEISGRHIGVESVKVTLEGDLLEALPAQGSFFLIKNVGIVRRNGYSVRKLVLL 1150
                             .|..::.|......|                        |::|:.::.
  Fly   603 -----------------GHARIQCVSENSTSD------------------------YTLREFLVS 626

  Fly  1151 YCIRVPQSASYHLQKIYCYHYWYPDWPDHHSPRD----INTLLDTCLHVLNLGKCESEFDIYDDT 1211
            :       .....::|  :||.:..||||..|.|    :|.|.|.
  Fly   627 W-------RDQPARRI--FHYHFQVWPDHGVPADPGCVLNFLQDV-------------------- 662

  Fly  1212 RSERNAHLAAQRLEIYQQDIFNAVQPLPV-IHCSAGIGRTGCFTAILNAVRQLRQSLAYSLTGML 1275
             :.|.:|||..           ..:|.|: :||||||||||.|..|...:.|:
  Fly   663 -NTRQSHLAQA-----------GEKPGPICVHCSAGIGRTGTFIVIDMILDQI------------ 703

  Fly  1276 TKSLTSSSTEEYHNPTDSDSSFTCNTIRHISHILDHRDAEAVKTPPSFDRLPKMPDIFVDVLGIV 1340
                       ..|..|::                                       :|:...:
  Fly   704 -----------VRNGLDTE---------------------------------------IDIQRTI 718

  Fly  1341 CNLRLQRGGMVQNSEQYELIHRAICLYLKRTLALRR 1376
            ..:|.||.|:||...||:.::.|:..|::..:|.:|
  Fly   719 QMVRSQRSGLVQTEAQYKFVYYAVQHYIQTLIARKR 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	Y_phosphatase	916..1364	CDD:278528	96/531 (18%)
PTP-ER	NP_726092.1	PTPc	917..1364	CDD:238006	95/530 (18%)
csw	NP_477131.1	SH2_C-SH2_SHP_like	211..307	CDD:198185	19/108 (18%)
		PTPc	326..744	CDD:214550	119/668 (18%)
		PTPc	543..743	CDD:238006	75/397 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443566
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930