Protein Alignment PTP-ER and Ptp99A

DIOPT Version :10

• Sequence 1: NP_726092.1
• Gene: PTP-ER / 37461
• FlyBaseID: FBgn0016641
• Length: 1377
• Species: Drosophila melanogaster
• Sequence 2: NP_651691.4
• Gene: Ptp99A / 43469
• FlyBaseID: FBgn0004369
• Length: 1397
• Species: Drosophila melanogaster
• Alignment Length: 1256
• Identity: 244/1256 - (19%)
• Similarity: 405/1256 - (32%)
• Gaps: 473/1256 - (37%)

  Fly   172 SEHNSPTILFKDESSTTPGLEASR--LSYSPKLLSSINNLNVSGSPLNIINSAGY---KNGNFFR 231
            :||:....|....:|||....|:|  |.:||::....:|..:..||....:::.|   .|..  .
  Fly    64 NEHSLVDTLVWKTASTTIAQFANRIPLLHSPRIQLLSDNFGLQFSPSLASDTSEYICLVNDR--H 126

  Fly   232 FPE--IDHVVQDAPMDTVCLEEATRRDRSPALAEPPEQQQQKSEGRKNRKNKNNLTIRITDVPIK 294
            .||  :|.:|||.|                   :|||           |....:.|.|..::...
  Fly   127 IPEAIVDLLVQDVP-------------------DPPE-----------RPLLISFTSRSVNLSWA 161

  Fly   295 NSSQPSPLPKPKTPTIKSTKEKARSLDSAANESELSIVVHNITESHGSCDDM--ETGQSQPSTSV 357
            :|..|...|                            |.|.|.|:....|.:  :..:....|:.
  Fly   162 HSQHPRNAP----------------------------VTHFIIETREGEDGIWEQLARIYTKTNA 198

  Fly   358 IHHHLHLQQPASAIHSTSLSRLDSHLSLANQRRTPRRKSPGINTTDWLMYHRKQNPYQVQPTHCS 422
            ..:.:....|.: ::|..|..::. |.:          ||....:.:::..|:....:..||...
  Fly   199 TSYQVTGLTPFT-VYSFRLLAVNK-LGI----------SPPSKESYYIVTLREAPTGKPIPTTAH 251

  Fly   423 STTQSSLDSDASLTPS---LGDFELKSACSVDGGSKFGIGASLAPRSAH---------KHNQLLH 475
            :|:.:|:.......|.   ||:|             .|...:..||...         :.|.:..
  Fly   252 NTSSTSVYISWKAPPPDTILGEF-------------LGYRITYRPRDRDPNDTKEIYIRDNTVES 303

  Fly   476 SSSTNLKTLPEC-LTLVEFSSSGGGPKESPFKQKSMDLPMPTLQAKTTVSTSSMNLLQRRGSNHS 539
            ....||:|..:. :|:..|:..|.||:.:....  .|..:|:.....|:...|.|         |
  Fly   304 HEIQNLQTYTQYKVTVQVFNPEGLGPETTILVM--TDEGVPSKPQNLTILDVSAN---------S 357

  Fly   540 LTLNLHSSCGNLMNSGLS-------HSNYS-LGSILNSKSSC---------NLDAGTASQI---- 583
            :|::.|..  ...|..::       |.|.: :..:.||::|.         ||...|..::
  Fly   358 ITMSWHPP--KNQNGAIAGYHVFHIHDNQTGVEIVKNSRNSVETLIHFELQNLRPYTDYRVIVKA 420

  Fly   584 --------RADQLPQ-SHLLGSSQGSRQGLFRRRGSNHSITLKTGHTTTSCGDLNSMQQLQQQQA 639
                    .:||:.| :.:.|.|..:...|...  |..|||::...
  Fly   421 FTTKNEGEPSDQIAQRTDVGGPSAPAIVNLTCH--SQESITIRWRR------------------- 464

  Fly   640 MLSAEKYNRLN---MRTNSTGSGSGSGSNVPTPKRGLLERRGSNQSLTLNMGSILGGAAGTEIQM 701
              ..|.||.::   ::|...|..:.....:....:. ||.....|:||.|....:..||.|
  Fly   465 --PYEFYNTIDFYIIKTRLAGQDTHRDIRINASAKE-LETAMILQNLTTNSYYEVKVAAAT---- 522

  Fly   702 TDIVQPKVTVCSCAAANQAPHQRKFFSTENLNSSKANSQKFFGQVCFGSASDLQPNPQQDSVRED 766
            ..::.||..|..            .||...:...:.|.:|            |||..:|.....:
  Fly   523 FSVINPKKIVLG------------KFSESRIIQLQPNCEK------------LQPLLRQSHNDYN 563

  Fly   767 QA--IGATCTCAGTVRNIMTRPLSPQTTSEEFKIYLASIQMLQSASNPLNQFDLIRLNYVFDHSY 829
            .|  :|...:|.|.:..||.             .:|.|.:...:|           ..|:.|..:
  Fly   564 LAVLVGIIFSCFGIILIIMA-------------FFLWSRKCFHAA-----------YYYLDDPPH 604

  Fly   830 QTNRNII--EQPPVLGSNARDVETPTDMVPPSSEDSELLASYQT----VVSRMAQPIPELKENEQ 888
            ..|...:  |.|..:|...|       ...|.:|.::.:||...    ..||..:.|       |
  Fly   605 HPNAPQVDWEVPVKIGDEIR-------AAVPVNEFAKHVASLHADGDIGFSREYEAI-------Q 655

  Fly   889 KRIFRDLHKEFWDLPLNHQEKPMVFGSQTKNRYKTILPNENSRVLLESESSELTSLLGEIKRTSS 953
            .....|      |||..|.:.|   .::.||||..|...::|||.|.....:
  Fly   656 NECISD------DLPCEHSQHP---ENKRKNRYLNITAYDHSRVHLHPTPGQ------------- 698

  Fly   954 VTASEDLPYINANYIKGPDYVSKCYVATQGPLPNTIFEFWLMIYQNTQRYIRRCVDGGSSSSPHV 1018
               .::|.|||||:|.|.. ....::.||||||:|...||.||:
  Fly   699 ---KKNLDYINANFIDGYQ-KGHAFIGTQGPLPDTFDCFWRMIW--------------------- 738

  Fly  1019 DREQILQQYFQKIVMLTNFTEANRQKCAVYFPIELNEIFAVAAKCEVFQLSAAARDYFDRYLTPT 1083
                  :|....|||:||..|..|:||.:|:|                      :|..:.|
  Fly   739 ------EQRVAIIVMITNLVERGRRKCDMYWP----------------------KDGVETY---- 771

  Fly  1084 FVPDTVVASSDAIDYEISGRHIGVESVKVTLEGDLLEALPAQGSFFLIKNVGIVRRNGYSVRKLV 1148
                                  ||..||: :|.:::..                    |:||.|.
  Fly   772 ----------------------GVIQVKL-IEEEVMST--------------------YTVRTLQ 793

  Fly  1149 LLYCIRVPQSASYHLQKIYCYHYWYPDWPDHHSPRDINTLLDTCLHVLNLGKCESEFDIYDDTRS 1213
            :.: :::.:....:.:|: .|.|.|.:||||.:|       |..|.|||..|..|
  Fly   794 IKH-LKLKKKKQCNTEKL-VYQYHYTNWPDHGTP-------DHPLPVLNFVKKSS---------- 839

  Fly  1214 ERNAHLAAQRLEIYQQDIFNAVQPLPVIHCSAGIGRTGCFTAILNAVRQLRQSLAYSLTGMLTKS 1278
                  ||...|         ..|: |:|||||:||||.:..:...::|::|           |:
  Fly   840 ------AANPAE---------AGPI-VVHCSAGVGRTGTYIVLDAMLKQIQQ-----------KN 877

  Fly  1279 LTSSSTEEYHNPTDSDSSFTCNTIRHISHILDHRDAEAVKTPPSFDRLPKMPDIFVDVLGIVCNL 1343
            :                                                      |:|.|.:.::
  Fly   878 I------------------------------------------------------VNVFGFLRHI 888

  Fly  1344 RLQRGGMVQNSEQYELIHRAI 1364
            |.||..:||..|||..:|.|:
  Fly   889 RAQRNFLVQTEEQYIFLHDAL 909

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	PTP_DSP_cys	919..1362	CDD:475123	94/442 (21%)
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020	22/165 (13%)
		FN3	243..337	CDD:238020	20/108 (19%)
		fn3	343..430	CDD:394996	15/97 (15%)
		FN3	442..520	CDD:238020	17/101 (17%)
		R5-PTPc-1	704..907	CDD:350397	85/399 (21%)
		R5-PTP-2	989..1182	CDD:350398