DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTP-ER and mop

DIOPT Version :9

Sequence 1:	NP_726092.1	Gene:	PTP-ER / 37461	FlyBaseID:	FBgn0016641	Length:	1377	Species:	Drosophila melanogaster
Sequence 2:	NP_648722.2	Gene:	mop / 39610	FlyBaseID:	FBgn0036448	Length:	1833	Species:	Drosophila melanogaster

Alignment Length:	1087	Identity:	219/1087 - (20%)
Similarity:	349/1087 - (32%)	Gaps:	304/1087 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NNKENAPIEYPYP-QTPRPTHAAPSDTTPLEAGEDAESNKSTPYFTPLEYLQTSFEFPSPTVEVG 70
            :|....|...|.| .:..||.||.|..|       |..|:..|   |....|..:..||
  Fly   754 SNPAYVPTVRPVPVGSENPTQAACSYAT-------APPNEPPP---PYSLTQQQYFDPS------ 802

  Fly    71 GGVPGF--PEHEDQEEEVFTPRQFTITSPHPAAHVHHPSSSQSPTLGRKFKRLSQYDRRSCSPHI 133
              ..|:  |.::.|::.:..|......||:        |.:....||:...:....|........
  Fly   803 --AAGYTNPMYQQQQQHIAPPAYKAQASPN--------SQTLHGALGQMNLQGQSQDNNQAGMAY 857

  Fly   134 NTSSGEERVSGRGIDKENTMP-KGGSVDQDLENSLYLSKSEHNSPTILFKDESSTTPGLEASRLS 197
            |.......|.........|:| ...|...:::..||::.|  .:|             :..|..|
  Fly   858 NYGYPSGSVPPLAYAPPGTVPASSASQGLNIQQPLYVATS--GNP-------------VSVSNPS 907

  Fly   198 YSPKLLSSINNLNVSGSPLNIINSAGYKNGNFFRFPEIDHVVQDAPMDTVCLEEATRRDRSPALA 262
            ..|..|.:...:|...:|..  .:||| :|..::  :::...|.....|.....:|.:.....|.
  Fly   908 ELPSTLQAPFVVNPMSNPYQ--TAAGY-SGQAYQ--QVNAQAQQVTYPTAPSGSSTGQSAQQPLG 967

  Fly   263 EPPEQ-QQQKSEGRKNRKNKNNLTIRITDVPIKNSSQPSPLPKPKTPTIKSTKEKARSLDSAANE 326
            ..|.| .||::.|....:............|:...:| ...|:.:|...:|...:.::...|.|:
  Fly   968 YAPSQGPQQQAGGYPQSQTPQQQVGAYQQQPLSGYAQ-QLTPQQQTGYSQSQAPQLQAPSYAQNQ 1031

  Fly   327 SELSIVVHNITESHGSCDDMETGQSQPSTSVIHHHLHLQQPASAIHSTSLSRLDSHLSLANQRRT 391
                       :|.|.....:||..|.....:..:...||.|:..               .|.:|
  Fly  1032 -----------QSTGQAQQQQTGYPQTPQQHLAGYAQSQQQATGY---------------PQSQT 1070

  Fly   392 PRRKSPGINTTDWLMYHRKQNP-----YQVQPT-HCSSTTQSSL-DSDASLTPSLGDFELKSACS 449
            .::::.|        |.:.|.|     ||.||: :.....|.|| ....||.||.         :
  Fly  1071 SQQQTTG--------YSQSQTPQQPLAYQQQPSGYPQQQQQQSLAPQQPSLYPSQ---------A 1118

  Fly   450 VDGGSKFGIGASLAPRSAHKHNQLLHSSSTNLKTLPECLTLVEFSSSGGGPKESPFKQKSMDLPM 514
            |....:...|....|.:|   .|.|        ..|:     :::.....|..:| ...|:..|:
  Fly  1119 VQASPQPIPGQQATPPNA---GQPL--------PYPQ-----QYTDPNAAPAPAP-GVSSVPSPV 1166

  Fly   515 PTLQAKTTVSTSSMNLLQRRGSNH-SLTLNLHSSCGNLMNSGLSHSNYSLGSILNSKSSCNLDAG 578
            |   ..|...|||.  .|...|.| |.|...:|          :|..||.          |...|
  Fly  1167 P---VPTPAPTSSQ--AQVPTSPHPSATYTSYS----------NHPGYSF----------NPQTG 1206

  Fly   579 TASQIRADQLPQSHLLGSSQGSRQGLFRRRGSNHSI-----------TLKTG-------HTTTSC 625
            ........|...|.|.| ||.|:...|.:.|...|:           ...||       ||..:.
  Fly  1207 KYEYSSGYQQDTSSLKG-SQASQSYQFSQSGKQQSVGTTDSEIASRSNTATGFDSPIVSHTKVNM 1270

  Fly   626 GDLNSMQQLQQQQAMLSAEKYNRLNMRTNSTGSGSGSGSNVPTPKRGLLERRGSNQSLTLNMGSI 690
            ...:|...::..:   |:..|:     |.....||.:....|||      ...||.:.::.|.|
  Fly  1271 AAKDSTSAIEGNE---SSNYYS-----TPYGYLGSVNPQQQPTP------APPSNSTASIYMQS- 1320

  Fly   691 LGGAAGTEIQMT-------------------DIVQPKVTV---------CSCAAANQAPH----- 722
             |.::..|.|.|                   :.:.||||.         ..|:.|...|.
  Fly  1321 -GASSTAETQTTSSGVPYASSAALTKVEPKPEALPPKVTSNVDLLSDLDIDCSVAVPPPMLPQPV 1384

  Fly   723 -QRKFFSTENLNSSKANSQKFFGQVCFGSASDLQPNPQQDSVREDQA-------IGATCTCAGTV 779
             |.:..:|..                 ..||.:....:.:||.|..|       :.||   .||.
  Fly  1385 LQPQVVATPT-----------------PPASQVSVPVKVESVAEHAAPATAEIPVAAT---EGTA 1429

  Fly   780 RNIMTRPLSPQTTSEEFKIYLASIQMLQSASNPLNQFDLIRL-NYVFDHSYQTNRNIIEQPPVLG 843
            :..:|.|..|:         .||:..|.:.|      ||..| |:.:| |.....::.|:.....
  Fly  1430 QTPVTIPSGPK---------CASLDNLSNCS------DLSSLENFDWD-SVSVTHSVSEKQTKAS 1478

  Fly   844 SNAR--------DVETPTDMVPPSSEDSELLASYQTVVSRM--------AQPIPELKENEQKRIF 892
            :.|.        ..||.||.........| :.||:.::..:        .|...:.:|.:||
  Fly  1479 ATANGHSSSFAFQSETFTDEKTTKYFQKE-VESYEKLLENLHVKMLNGKTQLGAKWQELQQK--- 1539

  Fly   893 RDLHKEFWDLPLNHQEKPMVFGSQTKNRYKTILPNENSRVLLESESSELTSLLGEIKRTSSVTAS 957
              |.||   ...|.:...:......|||....||.:::||.|:.::.:
  Fly  1540 --LDKE---AAANKRSTTIAKLFPEKNRSLDCLPYDHARVKLDKQTDD----------------- 1582

  Fly   958 EDLPYINANYIKGPDYVSKCYVATQGPLPNTIFEFWLMIYQNTQRYI 1004
                ||||.|:|........::..|.|.||||.:||.||:....|.:
  Fly  1583 ----YINAAYMKNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTV 1625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	Y_phosphatase	916..1364	CDD:278528	25/89 (28%)
PTP-ER	NP_726092.1	PTPc	917..1364	CDD:238006	25/88 (28%)
mop	NP_648722.2	BRO1_HD-PTP_like	2..363	CDD:185762
		V_HD-PTP_like	368..702	CDD:185747
		ALIX_LYPXL_bnd	421..699	CDD:290660
		Med15	808..>1246	CDD:255446	106/552 (19%)
		Y_phosphatase	1558..1788	CDD:278528	25/89 (28%)
		PTPc	1559..1745	CDD:238006	25/88 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900