DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTP-ER and Ptpmeg

DIOPT Version :9

Sequence 1:	NP_726092.1	Gene:	PTP-ER / 37461	FlyBaseID:	FBgn0016641	Length:	1377	Species:	Drosophila melanogaster
Sequence 2:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster

Alignment Length:	1075	Identity:	235/1075 - (21%)
Similarity:	356/1075 - (33%)	Gaps:	390/1075 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   421 CSSTTQSSLDSDASLTPSLGDFE-----------LKSAC--SVDGGSKFG----IGASLAPRSAH 468
            |||.||..|.| .::...||||.           ::..|  :.:...|.|    :.....|..|
  Fly   151 CSSNTQCLLAS-YTVQSELGDFNALEHQPGYLSGMQLLCDQTTEAERKVGELHKLHRGQLPADA- 213

  Fly   469 KHNQLLHSSSTNLKTLPECLTLVEFSSSGGGPKESPFKQKSMDLPMPTLQAKTTVSTSSMNLLQR 533
            ::|.|.|:....|..    :.|...:.|.|         |.:.|           ..|::.||.
  Fly   214 EYNYLEHAKRLELYG----IDLHRATDSNG---------KELQL-----------GVSAVGLLV- 253

  Fly   534 RGSNHSLTLNLHSSCGNLMNSGLSHSNYSLGSILNSKSSCNLDAGTASQIRADQLPQSHLLG--- 595
              ..|||.:|.. |...::.......::.:.  |..:.|.|.|.               |||
  Fly   254 --FQHSLRVNTF-SWSKMVKVSFKRKDFFIQ--LRREPSENYDT---------------LLGFGM 298

  Fly   596 SSQGSRQGLFRRRGSNHS-ITLKTGHTTT-----SCGD---LNSMQQLQQQQAMLSAEKYNRLNM 651
            ||....:.|::....:|| ..||..|..:     |.|.   .:...:||..|......:.:::.:
  Fly   299 SSHKHAKALWKSCVEHHSFFRLKRPHRLSRFLNISLGSKFYYSGRTELQAVQESKQRGRIHKVFV 363

  Fly   652 RTNS---TGSGSG---SGSNVPTPKRGLLERRGSNQSLTLNMGSILGGAAGTEIQMTDIVQPKVT 710
            |:.|   .|:..|   |||:..||   :.:..||..:.:.|.|...|  |||.:.:|...:|...
  Fly   364 RSPSKRLLGAAGGVGTSGSSGGTP---MQQHSGSESANSHNNGKPAG--AGTILTITKTSRPHDN 423

  Fly   711 VCSCAAANQAPHQRKFFSTENLNSSKANSQKFFG--QVC---FGSASDLQPNPQQDSVREDQAIG 770
            ..:...|:..|  ||.:..:   |.:.:.|...|  :.|   |.|||. .|.|...|..:...|.
  Fly   424 KVTSKEADSMP--RKAWEQQ---SDEYDIQLDVGFIEQCTRRFESASP-SPMPPAYSSGQHSPIL 482

  Fly   771 ATCTCAGTVRNIMTRPLSPQTTSEEFKIYLASIQMLQSASNPLNQFDL---IRLNYVFDH--SYQ 830
            ...|.|..|.:     ..|::.|:...|.|.:.:..:...|.....||   ::::.|..|  :.:
  Fly   483 LPTTIADAVGH-----QQPESGSDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADR 542

  Fly   831 TNRNIIEQPPVLGSNARDV-----ETPTDMVPPSSEDS--ELLASYQTVVSR--------MAQPI 880
            ....:.|...||..|.|||     |....|:......:  |||.:.:...|.        :.|.:
  Fly   543 CTPRVCEGDEVLMINGRDVHGLRHEQVVAMIRDCRHQASGELLLTVRPQRSAPLLLEEEPLYQYV 607

  Fly   881 PELKE--------------NEQKRIFRD-------------LHKEFWDLPLNHQEKPMVFGSQTK 918
            ||..|              .:...:..|             ::::..||.:....||   .:..|
  Fly   608 PESDEIGSHSNLLDGDALFTQSLLLLSDGLASGALLAQYELMYRKNPDLAITEARKP---ANAPK 669

  Fly   919 NRYKTILPNENSRVLLESESSELTSLLGEIKRTSSVTASEDLPYINANYI--KGPDYVSKCYVAT 981
            |||:.|.|.:.:||.|      :.||.|:              ||||||:  :.|......|:||
  Fly   670 NRYRDISPYDCTRVSL------VNSLTGD--------------YINANYVNMEIPGGAVNRYIAT 714

  Fly   982 QGPLPNTIFEFWLMIYQNTQRYIRRCVDGGSSSSPHVDREQILQQYFQKIVMLTNFTEANRQKCA 1046
            ||||.:|..:||.|:.|               .|.|:            :||||...|:.||||.
  Fly   715 QGPLASTTTDFWRMVQQ---------------ESSHL------------LVMLTTVMESGRQKCH 752

  Fly  1047 VYFPI-----ELNEIFAVAAKCEVFQLSAAARDYFDRYLTPTFVPDTVVASSDAIDYEISGRHIG 1106
            .|:|:     :|.|.|:|  :|
  Fly   753 QYWPVTGEELQLAEGFSV--RC------------------------------------------- 772

  Fly  1107 VESVKVTLEGDLLEALPAQGSFFLIKNVGIVRRNGYSVRKLVLLYCIRVPQSASYHLQKIYCYHY 1171
                       |.|.....|||..              |:.||         ...|.|: :.:|.
  Fly   773 -----------LSEKPDETGSFVF--------------REFVL---------KDKHEQR-HIHHM 802

  Fly  1172 WYPDWPDHHSPRDINTLLD-----------TCLHVLNLGKCES--EFDIYD-DTRSERNAHLAAQ 1222
            .|..||||..|.|.|..|:           |.|..:.    ||  :..:.| |..::.|..|..:
  Fly   803 QYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIE----ESLKQVRLMDADADADENGGLMRE 863

  Fly  1223 R-----------------LEIYQQDIFNAVQPLPVIHCSAGIGRTGCFTAILNAVRQLRQSLAYS 1270
            |                 ..::|  ..:|..|..::||||||||||....:..|:..:
  Fly   864 RKCAASNGATPEDETPVSTSVHQ--CISAANPPVIVHCSAGIGRTGVLILMDTALALM------- 919

  Fly  1271 LTGMLTKSLTSSSTEEYHNPTDSDSSFTCNTIRHISHILDHRDAEAVKTPPSFDRLPKMPDIFVD 1335
                                                        ||        |.|..|
  Fly   920 --------------------------------------------EA--------REPVYP----- 927

  Fly  1336 VLGIVCNLRLQRGGMVQNSEQYELIHRAIC-LYLK 1369
             |.||..:|.||..||||..||..:...|| .|:|
  Fly   928 -LDIVRTMRDQRACMVQNVSQYRFVCECICAAYMK 961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	Y_phosphatase	916..1364	CDD:278528	109/485 (22%)
PTP-ER	NP_726092.1	PTPc	917..1364	CDD:238006	109/484 (23%)
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	20/86 (23%)
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785	20/86 (23%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	26/138 (19%)
		FA	333..369	CDD:285894	7/35 (20%)
		PDZ_signaling	502..589	CDD:238492	19/86 (22%)
		Y_phosphatase	666..955	CDD:278528	109/486 (22%)
		PTPc	668..955	CDD:238006	109/484 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443571
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930