DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTP-ER and Pez

DIOPT Version :9

Sequence 1:	NP_726092.1	Gene:	PTP-ER / 37461	FlyBaseID:	FBgn0016641	Length:	1377	Species:	Drosophila melanogaster
Sequence 2:	NP_001260127.1	Gene:	Pez / 33882	FlyBaseID:	FBgn0031799	Length:	1252	Species:	Drosophila melanogaster

Alignment Length:	1374	Identity:	247/1374 - (17%)
Similarity:	399/1374 - (29%)	Gaps:	543/1374 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 IDK------ENTMPKGGS-----VDQDLENSLY---LSKSEHNSPTILFKDESSTTPGLEASRLS 197
            |||      :|.:..|||     :..:.:.:.|   |:.|:|.    .||....|.
  Fly   270 IDKRTIKIEQNKLDGGGSIVGSFIFSEADTARYFWKLTISQHK----FFKRYIDTA--------- 321

  Fly   198 YSPKLLSSINNLNVSGSPLNIINSAGYKNGNFFRFPEIDHVVQDAPMDTVCLEEATRRDRSPALA 262
             :|..|.|  ..:....||. ::|.||          :|:...:|    ...|:..:..:.....
  Fly   322 -TPSSLGS--GADAESGPLG-VDSVGY----------VDYDYNEA----AAAEQLQQHHQQQQHM 368

  Fly   263 EPPEQQQQKS--------------------------------------EGRKNRKNKNNLTIRIT 289
            :..:|.||:.                                      .|..|..|.|:...|:
  Fly   369 QQQQQIQQQQMISSNISLATSANQMLGQSSSCLDLSNNNLHSSSGMLHHGGSNNNNNNDERERL- 432

  Fly   290 DVPIKNSSQPSPLPKPKTPTIKSTKEKARSLDSAANESELSIVVHNITESHGSCDDMETGQSQPS 354
                 .:..|:..|.|...|....|.:..|.:           .||:..:..:..:.....|||.
  Fly   433 -----KAMLPTYRPAPDYETAVQLKYRTPSAE-----------FHNVALAMAAPGNAYYAGSQPD 481

  Fly   355 ---------------------------TSVIHHHLHL----QQPASAIHSTSLSRLDSHLSLANQ 388
                                       .:.:|||::|    .||.|  |...:|...::|.|:.:
  Fly   482 VHNPGMHNENLLYGHMTAHRYPDVAQPAAALHHHINLYQAQHQPQS--HPQPMSPAQAYLELSQR 544

  Fly   389 RRTPRRKSPGINTTDWLMYHRKQNPYQVQPTHCSSTTQSSLDSDASLTPSLGDFELKSACS---V 450
            ....|.|:|               |..|.....|||...::   |:..|..|.....|..|   |
  Fly   545 MHMMRHKAP---------------PPYVNRLSSSSTPDLAV---ATPRPLQGFRNYVSGSSPDLV 591

  Fly   451 DGGSKFGIGASLA-PRSAHKHNQLLHSSSTNLKTLPECLTLVEFSSSGGG-----PKESPFKQKS 509
            ...:.|..|..:| |...|..|....|.:|.|..       .::.|..|.     |....|:..:
  Fly   592 SNRTLFNGGQYVALPAGGHAGNIPTSSGATMLHQ-------YQYVSHMGHSQPYLPPHGTFENLN 649

  Fly   510 MDLPMPTLQAKTTVSTSSMNLLQRRGS---NHSLTL---NLHSSCGNLMNSGL-------SHSNY 561
            |....|::.::...|..|.......||   ..|.||   ...||.....:|.|       ||.:.
  Fly   650 MIEEQPSIMSQLRQSAMSQAAAAAAGSVVTQSSPTLPPSGYRSSVPPPASSPLPPPVVASSHKSA 714

  Fly   562 SLGSILNSKSSCNLDAGTASQIRAD-QLPQSHLLGSSQGSRQGLFRRRGSNHSITLKTGHTTTSC 625
            :...:..|     |..|:...|..: .|||....|||..:.....|:|.|:
  Fly   715 TPAPLQRS-----LVNGSIEPIYENVPLPQRASGGSSGAANTEAMRQRASS-------------- 760

  Fly   626 GDLNSMQQLQQQQAMLSAEKYNRLNMRTNSTGSGSGSGSNVPTPKRGLLERRGSNQSLTLNMGSI 690
              :.|...:....|..:|...|.:.:..||            .|..|.:::.|:::
  Fly   761 --IQSAPGVVPVPAARNASSNNVVTVTVNS------------PPDDGNIKKYGADR--------- 802

  Fly   691 LGGAAGTEIQMTDIVQPKVTVCSCAAA---NQAPHQRKFFSTENLNSSK----------ANSQKF 742
               ||.||:...:...||.|..:.:||   ...|..|:..||.:||.|.          ...|:|
  Fly   803 ---AASTELLFLEPQAPKRTNRAASAAPDMGATPPPRQHRSTASLNKSSTVDMITPAGDTLQQQF 864

  Fly   743 FGQVCFGSASDLQPNPQ-QDSVREDQAIGATCTCAGTVR-------NIMTRPLSPQ--------- 790
                   ||.:|..|.. ..|...:..:..|.:.|.:..       |.::|..:|.
  Fly   865 -------SAMNLSANTSASTSSMFNSTLDTTSSSAASKDLKRKKRWNFLSRSKTPDKQKSATLGR 922

  Fly   791 ---TTSEEFKIYLASIQMLQSASNPLNQFDLIRLNYVFDHSYQTNRNIIEQPPVLGSNARDVETP 852
               ||:.:.....|.:::.|...|..|::               :..:.:..|:.|..::|  ..
  Fly   923 EKATTAGQHSKLAAKLKLAQDDLNLPNRW---------------STGVNKPQPISGRYSKD--KL 970

  Fly   853 TDMVPPSSEDSELLASYQTVVSRMAQPIPE---LKENEQKRIFRDLHKEFWDLPLNHQEKPMVFG 914
            ..::.....||:|...::.:..|....:.|   |:|||               |.||.
  Fly   971 CQILDQKLSDSQLFMEFERIPKRREHALYECALLEENE---------------PKNHD------- 1013

  Fly   915 SQTKNRYKTILPNENSRVLLESESSELTSLLGEIKRTSSVTASED--LPYINANYIKGP-DYVSK 976
                   ...||.:::||.|                    |...|  ..|:||:.|... ....:
  Fly  1014 -------PNFLPYDDNRVRL--------------------TPCRDNRHGYVNASSISATVGTKQR 1051

  Fly   977 CYVATQGPL-PNTIFEFWLMIYQNTQRYIRRCVDGGSSSSPHVDREQILQQYFQKIVMLTNFTEA 1040
            .|:..|.|. |.|:..||            :||                             .||
  Fly  1052 FYIVAQSPQEPLTMRIFW------------QCV-----------------------------WEA 1075

  Fly  1041 NRQKCAVYFPIELNEIFAVAAKCEVFQLSAAARDYFDRYLTPTFVPDTVVASSDAIDYEISGRHI 1105
            :     ||..::|.|           .:|...|:...|.....|          .:..|.|....
  Fly  1076 D-----VYLVVQLTE-----------DMSYIPRNSHQRLEFGQF----------QVYQEFSQTTD 1114

  Fly  1106 GVESVKVTLEGDLLEALPAQGSFFLIKNVGIVRRNGYSVRKLVLLYCIRVPQSASYHLQKIYCYH 1170
            ...::|:.|                                              ||:.......
  Fly  1115 RCTTIKLRL----------------------------------------------YHVPSRRYRS 1133

  Fly  1171 YW---YPDWPDHHSPRDINTLLDTCLHVLNLGKCESEFDIYDDTRSERNAHLAAQRLEIYQQDIF 1232
            .|   |.||.:.:.|||:|..|| .|..||..:..|       |:.....|
  Fly  1134 VWYLQYADWAEQNCPRDVNHFLD-FLEELNSVRLAS-------TQEVPPGH-------------- 1176

  Fly  1233 NAVQPLPVIHCSAGIGRTGCFTAILNAVRQLRQSLAYSLTGMLTKSLTSSSTEEYHNPTDSDSSF 1297
            |...|: ::||..|.||:|.                     .||..|
  Fly  1177 NTNPPV-LLHCLEGGGRSGV---------------------TLTADL------------------ 1201

  Fly  1298 TCNTIRHISHILDHRDAEAVKTPPSFDRLPKMPDIFVDVLGIVCNLRLQRGGMVQNSEQYELIHR 1362
                   :.:.|||.:.                   :|:..::..||.||..::.:..||:.|:.
  Fly  1202 -------LLYTLDHNED-------------------LDIPRVIGQLRHQRDSIIPSLAQYKFIYN 1240

  Fly  1363 AICLYLKRT 1371
            .:..|||||
  Fly  1241 LLITYLKRT 1249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	Y_phosphatase	916..1364	CDD:278528	74/454 (16%)
PTP-ER	NP_726092.1	PTPc	917..1364	CDD:238006	74/453 (16%)
Pez	NP_001260127.1	B41	26..230	CDD:214604
		FERM_N	26..93	CDD:286467
		FERM_M	114..230	CDD:278785
		FERM_C_PTPN14_PTPN21	225..317	CDD:270009	13/50 (26%)
		Y_phosphatase	1007..1243	CDD:278528	79/485 (16%)
		PTPc	1009..1243	CDD:238006	77/468 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443545
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930