DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTP-ER and IA-2

DIOPT Version :9

Sequence 1:	NP_726092.1	Gene:	PTP-ER / 37461	FlyBaseID:	FBgn0016641	Length:	1377	Species:	Drosophila melanogaster
Sequence 2:	NP_608562.4	Gene:	IA-2 / 33277	FlyBaseID:	FBgn0031294	Length:	1319	Species:	Drosophila melanogaster

Alignment Length:	1604	Identity:	270/1604 - (16%)
Similarity:	447/1604 - (27%)	Gaps:	662/1604 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 EYPYPQTPRPTHAAPSDTTPLEAGEDAES----NKSTPYFTPLEYLQTSFEFPSPTVEVGGGVPG 75
            ::|...|..|.|.....|...:.....|.    :|..|   |.:..|
  Fly    23 QHPCTTTEEPKHQRARGTAGHQESATGECQQFWSKQRP---PFDQQQ------------------ 66

  Fly    76 FPEHEDQEEEVFTPRQFTITSPHPAAHVHHPSSSQ----------SPTLGRKFKRL--------- 121
              :.|||:.|. .|:|...| |..:.| ||.|..|          .|||..:.:.|
  Fly    67 --QQEDQDPEQ-DPQQHPST-PQESVH-HHRSPRQHELLHHQRKVPPTLPARGRHLISEGARRRE 126

  Fly   122 ---------------------------------------------------SQYDRRSCSPHINT 135
                                                               .|:.|..|.||...
  Fly   127 VRGCGAGGGGLLCCSLDALSRPAKLLQFGVLLLILLLATHGDLAQAEGNVGCQFVRTLCIPHSEV 191

  Fly   136 SSGEERVSGR-----GIDKEN---------------TM---PKGGSVDQD-------LENSLYLS 170
            .. ::.:.|:     |:|.|:               ||   .:|..:..|       ::.||:..
  Fly   192 CY-DDNIFGKCIPTTGVDVEDIEKTPLTEDQSRVLATMLEELQGAGLGWDHPYVQCRIQGSLFSL 255

  Fly   171 KSEHNSPTILFKDESSTTP--GLEASRLSY----SPKLLSSINNLNVSGSPLNIINSAGYKN--- 226
            :.:...|..|..:.:.|.|  |..||.|:|    .|:..:.::.......|.....:...|.
  Fly   256 QRQQQLPPNLCANLAPTPPEFGDPASALAYVRFTPPEPEAELDYYEQPAGPAQFYPALRKKQVRE 320

  Fly   227 ----------------------GNFFRFPEIDHVVQDAPMDTVCLEEA---TRRDRSPALAEPPE 266
                                  .....|.::|...|...:|...:.:|   |.|.|...     |
  Fly   321 SDADDMYLNRMLQDRRRLRHDPSELEHFGKMDGHGQSTQLDAPSIMDAFLDTERQRIER-----E 380

  Fly   267 QQQQKSEGRKNRKNKNNLTIRITDVPIKNSSQPSPLPKPKTPTIKST----------KEKARSLD 321
            ||...:|...:|:.:.|   |:....|..:|:|.|.|..:.|..:..          :::.|.|.
  Fly   381 QQLAAAEQDADRRAEQN---RLELYQILAASEPDPQPYQRKPAAQPNAMDQLEAIVEQQQQRELK 442

  Fly   322 SAANESELSIVV--HNITESH--------------------GSCDDMETGQ-------------- 350
            ....:::..:.|  ..:.||.                    |..:::|..|
  Fly   443 EQQEQAKAPVYVPPEEVNESSELYFPDNFAPFKRARGRSRGGLAEEVEDEQPKRSFFRELAGEQG 507

  Fly   351 --SQPSTSVIH------------------------HHLHLQQPASAIHS----TSLSRLDSHLSL 385
              .:|.....|                        :.:.|||...|..|    .||:.|:....|
  Fly   508 LVQEPPLRFRHVETEVDATPELVKRRPASFKQLDPYDVSLQQQEMAFESGLLRNSLTPLEEEAML 572

  Fly   386 ANQRRTPRRKSPGINTTD--WLMYHRKQNPYQVQPTHCSSTTQSSLDSDASLT------------ 436
            |:.....:.||..:.|..  .||...:|:...:|.....:..||.|.:.....
  Fly   573 ASNSFPRQAKSQRVYTEGGLLLMPQDEQDTDGMQADEPENVKQSLLANMLGFARHERLDVKKPGP 637

  Fly   437 ----PSLGDFELKSACSVDGGSKFGIGASLAPRSAHKHNQLLHSSSTNLKTLPECLTLVEFSSSG 497
                ||||..||.:              .|....|||  |..|.   |.:.||..:.
  Fly   638 LLGPPSLGSAELSN--------------QLETEKAHK--QKGHG---NKEVLPAHIK-------- 675

  Fly   498 GGPKESPFKQKSMDLPMPTLQ--AKTTVSTSSMNLLQRRGSNHSLTLNLHSSCGNLMNSGLSHSN 560
            |..::...|:|.:.....:.:  |..||.|..:         |....|...|    .|.| ....
  Fly   676 GNDEDDAHKKKKVMKQQHSAEDHAPHTVDTEYV---------HVFVKNPIDS----WNDG-QRIM 726

  Fly   561 YSLGSILNSKSSCNLDAGTASQIRADQLPQSHLLGSSQGSR-------QGLFRRRGSNHSITLKT 618
            ..|..||:.:       |..|.:...|...|..:.|:...|       :.:...||..::|..:.
  Fly   727 KELEQILHMQ-------GYFSYLTVQQHEVSFRVNSNNPERKTAGDVARTINENRGVKNNIQRRV 784

  Fly   619 GHTTTSCGDLNSMQQLQQQQAMLSAEKYNRLNMRTNSTG------SGSGSGSNVPTPKRGLLERR 677
            |......|..:.::.||...  :|:.:........:.|.      :|:|:.:.:......:|.:|
  Fly   785 GFYVLHAGVGDVIKDLQDPS--VSSSRIELAEQGPDVTHIMAYMFAGAGAAAVIVIFVTLILIKR 847

  Fly   678 GSNQSLTLNMGSILGGAAGTEIQMTDIVQPKVTVCSCAAANQAPHQRKFFSTENLNSSKANSQKF 742
            ...:...|  |.:..|.||.|....|..:    :|....|.:|             ....||.
  Fly   848 HDRKRDKL--GGLQSGIAGAETCSKDYQE----LCRARMAGKA-------------GGGGNST-- 891

  Fly   743 FGQVCFGSASDLQPNPQQDSV-REDQAIGATCTCAGTVRNIMTRPLSPQTTSEEFKIYLASIQML 806
             |....|.:::..|:.:..|: :|::.                ||.|.::::..:
  Fly   892 -GGAAGGGSNEPAPSGRITSLSKENEG----------------RPPSSRSSTSSW---------- 929

  Fly   807 QSASNPLNQFDL----IRLNYVFDHSYQTNRNIIEQPPVLGSNARDVETPTDMVPPSSEDSELLA 867
             |....|...|:    :.|:|:.||.....|                         ...:.|.|.
  Fly   930 -SEEPALTNMDISTGHMVLSYMEDHLRNKGR-------------------------LQREWEALC 968

  Fly   868 SYQTVVSRMAQPIPELKENEQKRIFRDLHKEFWDLPLNHQEKPMVFGSQTKNRYKTILPNENSRV 932
            .|:..        |..:|                    ...:|...|   .||....||.::|||
  Fly   969 RYEAE--------PSARE--------------------AASQPQCAG---LNRPGAPLPYDHSRV 1002

  Fly   933 LLESESSELTSLLGEIKRTSSVTASEDLPYINANYIKGPDYVSKCYVATQGPLPNTIFEFWLMIY 997
            :|                 :.:..:|.|.|:||:.|...|..:..|||.|||||:|:..||.||:
  Fly  1003 VL-----------------NHLANAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIW 1050

  Fly   998 QNTQRYIRRCVDGGSSSSPHVDREQILQQYFQKIVMLTNFTEANRQKCAVYFPIELNEIFAVAAK 1062
                                       :|....||.|....|.....||.|:|.|..|::.:
  Fly  1051 ---------------------------EQGAVVIVALCRLQENGEVACARYWPEEGAEVYHI--- 1085

  Fly  1063 CEVFQLSAAARDYFDRYLTPTFVPDTVVASSDAIDYEIS--GRHIGVESVKVTLEGDLLEALPAQ 1125
                                               ||:.  ..||..:...|.
  Fly  1086 -----------------------------------YEVHLVSEHIWCDDYLVR------------ 1103

  Fly  1126 GSFFLIKNVGIVRRNGYSVRKLVLLYCIRVPQSASYHLQKIYCYHYWYPDWPDHHSPRDINTLLD 1190
             ||:| ||                   :|..::     :.:..:|:.  .||....|.....|||
  Fly  1104 -SFYL-KN-------------------LRTSET-----RTVTQFHFL--SWPHMGVPAQAKALLD 1140

  Fly  1191 TCLHVLNLGKCESEFDIYDDTRSERNAHLAAQRLEIYQQDIFNAVQPLPVIHCSAGIGRTGCFTA 1255
                        ....:....|..|:..:                    |:|.|||.||||
  Fly  1141 ------------FRRKVNKSYRGRRSCPI--------------------VVHGSAGAGRTG---- 1169

  Fly  1256 ILNAVRQLRQSLAYSLTGMLTKSLTSSSTEEYHNPTDSDSSFTCNTIRHISHILDHRDAEAVKTP 1320
                        .|.|..::.:.:...:.|
  Fly  1170 ------------VYILLDLVLERMNKGARE----------------------------------- 1187

  Fly  1321 PSFDRLPKMPDIFVDVLGIVCNLRLQRGGMVQNSEQYELIHRAI 1364
                         :|:...:.:||.||.|:|...:|:|.:..|:
  Fly  1188 -------------IDIAATLEHLRDQRAGVVATRQQFEFVLMAV 1218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	Y_phosphatase	916..1364	CDD:278528	80/449 (18%)
PTP-ER	NP_726092.1	PTPc	917..1364	CDD:238006	80/448 (18%)
IA-2	NP_608562.4	Receptor_IA-2	708..795	CDD:288410	19/107 (18%)
		PTPc	960..1220	CDD:214550	88/508 (17%)
		PTPc	995..1220	CDD:238006	79/442 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443536
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930