DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTP-ER and Ptp10D

DIOPT Version :9

Sequence 1:	NP_726092.1	Gene:	PTP-ER / 37461	FlyBaseID:	FBgn0016641	Length:	1377	Species:	Drosophila melanogaster
Sequence 2:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster

Alignment Length:	1640	Identity:	302/1640 - (18%)
Similarity:	502/1640 - (30%)	Gaps:	656/1640 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KENAPIEYPYPQTPRPTHAAPSDTTPLEA--------GEDAESNKSTPYF--TPLEYLQTSFE-- 61
            ||..|        |.|..||.....|..|        .||..|..:|..:  .||..|..:|:
  Fly   267 KEGEP--------PGPAQAAFKGLVPGRAYNISVQTMSEDEISLPTTAQYRTVPLRPLNVTFDRD 323

  Fly    62 -FPSPTVEVGGGVP-GFPEHEDQEEEVFTP-RQFTITSPHPAAHVHHPSSSQSPTLGRKFKRLSQ 123
             ..|.:..|....| |..|.:..:..|.|. ||.|:           |.|:: |.....|:.:::
  Fly   324 FITSNSFRVLWEAPKGISEFDKYQVSVATTRRQSTV-----------PRSNE-PVAFFDFRDIAE 376

  Fly   124 YDRRSCSPHINTSSGE-----------------ERVSGRGIDKENTMPKGGSVD----QDLENSL 167
             ..::.:..:.|.||:                 ..:.....||.|||......|    ||....:
  Fly   377 -PGKTFNVIVKTVSGKVTSWPATGDVTLRPLPVRNLRSINDDKTNTMIITWEADPASTQDEYRIV 440

  Fly   168 Y-------------------------------------LSKSEHNSPTILF----------KDES 185
            |                                     :||...::.|.:|          :|..
  Fly   441 YHELETFNGDTSTLTTDRTRFTLESLLPGRNYSLSVQAVSKKMESNETSIFVVTRPSSPIIEDLK 505

  Fly   186 STTPGLEAS------------RLSYSPKLLSSINNLNVSGSPLNIIN---SAGYKNGNFFRFPEI 235
            |...||..|            .:.||....|.:.......|.|.|.|   .|||:...|    .:
  Fly   506 SIRMGLNISWKSDVNSKQEQYEVLYSRNGTSDLRTQKTKESRLVIKNLQPGAGYELKVF----AV 566

  Fly   236 DHVVQDAP----------------MDTVCLEEATRRDRSPALA---EPPEQQQQKSEGRKNRKNK 281
            .|.::..|                ::||         ||.::.   .|||..:......:.|.:.
  Fly   567 SHDLRSEPHAYFQAVYPNPPRNMTIETV---------RSNSVLVHWSPPESGEFTEYSIRYRTDS 622

  Fly   282 NNLTIR----------ITDV-------------------PIKNSSQPSPLPKPKTPTIKSTKEKA 317
            ....:|          |||:                   |:......:..|.|.:..|:....:.
  Fly   623 EQQWVRLPSVRSTEADITDMTKGEKYTIQVNTVSFGVESPVPQEVNTTVPPNPVSNIIQLVDSRN 687

  Fly   318 RSLDSAANESELS--------------IVVHNITESHGSCDDMET-----GQSQPSTSVIHHHLH 363
            .:|:....|..:.              :...|::|:. |.||:.|     |:..|.   :.:...
  Fly   688 ITLEWPKPEGRVESYILKWWPSDNPGRVQTKNVSENK-SADDLSTVRVLIGELMPG---VQYKFD 748

  Fly   364 LQQPA-------SAIHSTSLSRLDSHLSLANQRRTPRRKSPGINTTDWLMYHRKQNPYQVQPTHC 421
            :|..:       ::::..::..:.|.:.:||..:...|.:..::.|
  Fly   749 IQTTSYGILSGITSLYPRTMPLIQSDVVVANGEKEDERDTITLSYT------------------- 794

  Fly   422 SSTTQSSLDSDASLTPSLGDFELKSACSVDGGSKFGIGASLAPRSAHKHNQLLHSSSTNLKTLPE 486
             .|.|||...|. ...||||.|::..            ..||..:..|      .:.|.|  :|.
  Fly   795 -PTPQSSSKFDI-YRFSLGDAEIRDK------------EKLANDTDRK------VTFTGL--VPG 837

  Fly   487 CLTLVEFSSSGGGPKESPFKQKSMDLPMPTLQAKTTVSTSSMNLLQ---RRGSNHSLTLNLHSSC 548
            .|..:...:..||....|.:::....|.|..|...|..|.:...|:   .:|..:...: .:.:.
  Fly   838 RLYNITVWTVSGGVASLPIQRQDRLYPEPITQLHATNITDTEISLRWDLPKGEYNDFDI-AYLTA 901

  Fly   549 GNLMNSGLS------------HSNYSLGSILNS-------KSSCNLDA---------GTASQIRA 585
            .||:...::            |.||:...::.|       :||..|.|         |...:...
  Fly   902 DNLLAQNMTTRNEITISDLRPHRNYTFTVVVRSGTESSVLRSSSPLSASFTTNEAVPGRVERFHP 966

  Fly   586 DQLPQSHL-----LGSSQGSRQGLFRRRGSNHSITLKTGHTTTSCGDLNSMQQLQQQQA------ 639
            ..:..|.:     |.||:.:  |:.|:    .||.....:..|..|    ||..:.::|
  Fly   967 TDVQPSEINFEWSLPSSEAN--GVIRQ----FSIAYTNINNLTDAG----MQDFESEEAFGVIKN 1021

  Fly   640 MLSAEKYNRLNMRTNSTGSGSGSGSNVPTPKRGLLERRGSNQSLTLNMGSILGGAAGTEIQMTDI 704
            :...|.|........:.|.|         |:|   |.|.:       |..:......|::..|::
  Fly  1022 LKPGETYVFKIQAKTAIGFG---------PER---EYRQT-------MPILAPPRPATQVVPTEV 1067

  Fly   705 VQPKVTVCSCAAANQAPHQRKFFSTENLNSSKANSQKFFGQVCF----------GSASDLQ-PN- 757
            .:...|:       |...::.:||.:|            |||..          .:||.|: |:
  Fly  1068 YRSSSTI-------QIRFRKNYFSDQN------------GQVRMYTIIVAEDDAKNASGLEMPSW 1113

  Fly   758 -------------------PQQDSVREDQAIGATCTC-------------AGTVRNIMTRPLSPQ 790
                               |.::...||..|| |..|             :||...:..|..
  Fly  1114 LDVQSYSVWLPYQAIDPYYPFENRSVEDFTIG-TENCDNHKIGYCNGPLKSGTTYRVKVRAF--- 1174

  Fly   791 TTSEEF--KIYLASIQ-------MLQSASNPLNQFDLIRLNYVFDHSYQTNRNIIEQPPVLGSNA 846
            |.:::|  ..|...||       ::.:.:.||....::.:..:|   |:..||...:      ..
  Fly  1175 TGADKFTDTAYSFPIQTDQDNTSLIVAITVPLTIILVLLVTLLF---YKRRRNNCRK------TT 1230

  Fly   847 RDVETPTDMVPPSS---EDSELL----ASYQTVVS-----RMAQPIPELKENEQKRIFRDLHKEF 899
            :|.....:|..|.|   ::..:|    |.:..::|     |.::...||     |.:.||....|
  Fly  1231 KDSRANDNMSLPDSVIEQNRPILIKNFAEHYRLMSADSDFRFSEEFEEL-----KHVGRDQPCTF 1290

  Fly   900 WDLPLNHQEKPMVFGSQTKNRYKTILPNENSRVLLESESSELTSLLGEIKRTSSVTASEDLPYIN 964
            .|||.|          :.|||:..|||.::||..|:                 .|...|...|||
  Fly  1291 ADLPCN----------RPKNRFTNILPYDHSRFKLQ-----------------PVDDDEGSDYIN 1328

  Fly   965 ANYIKGPDYVSKCYVATQGPLPNTIFEFWLMIYQNTQRYIRRCVDGGSSSSPHVDREQILQQYFQ 1029
            |||:.|.:...: ::.|||||.:|..:||.|.:::..|
  Fly  1329 ANYVPGHNSPRE-FIVTQGPLHSTRDDFWRMCWESNSR--------------------------- 1365

  Fly  1030 KIVMLTNFTEANRQKCAVYFPIELNEIFAVAAKCEVFQLSAAARDYFDRYLTPTFVPDTVVASSD 1094
            .|||||...|..|:||..|:|.:...:|....|.::...|    .|.|..:|
  Fly  1366 AIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDS----HYADWVMT------------- 1413

  Fly  1095 AIDYEISGRHIGVESVKVTLEGDLLEALPAQGSFFLIKNVGIVRRNGYSVRKLVLLYCIRVPQSA 1159
                                     |.:..:||     ...|:|
  Fly  1414 -------------------------EFMLCRGS-----EQRILR--------------------- 1427

  Fly  1160 SYHLQKIYCYHYWYPDWPDHHSPRDINTLLDTCLHVLNLGKCESEFDIYDDTRSERNAHLAAQRL 1224
                      |:.:..|||...|....||:              .|     .|:.|:...|.||
  Fly  1428 ----------HFHFTTWPDFGVPNPPQTLV--------------RF-----VRAFRDRIGAEQR- 1462

  Fly  1225 EIYQQDIFNAVQPLPVIHCSAGIGRTGCFTAILNAVRQLRQSLAYSLTGMLTKSLTSSSTEEYHN 1289
                        |: |:|||||:||:|.|..:...::|:                         |
  Fly  1463 ------------PI-VVHCSAGVGRSGTFITLDRILQQI-------------------------N 1489

  Fly  1290 PTDSDSSFTCNTIRHISHILDHRDAEAVKTPPSFDRLPKMPDIFVDVLGIVCNLRLQRGGMVQNS 1354
            .:|                                        :||:.|||..:|.:|..|||..
  Fly  1490 TSD----------------------------------------YVDIFGIVYAMRKERVWMVQTE 1514

  Fly  1355 EQYELIHRAICLYLK 1369
            :||..||:.:...|:
  Fly  1515 QQYICIHQCLLAVLE 1529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	Y_phosphatase	916..1364	CDD:278528	91/447 (20%)
PTP-ER	NP_726092.1	PTPc	917..1364	CDD:238006	91/446 (20%)
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470	12/44 (27%)
		fn3	315..391	CDD:278470	18/88 (20%)
		FN3	405..494	CDD:238020	13/88 (15%)
		FN3	511..574	CDD:238020	14/66 (21%)
		FN3	583..671	CDD:238020	13/96 (14%)
		fn3	683..753	CDD:278470	11/73 (15%)
		fn3	787..850	CDD:278470	18/103 (17%)
		fn3	866..935	CDD:278470	11/69 (16%)
		fn3	961..1043	CDD:278470	17/100 (17%)
		PTPc	1272..1525	CDD:214550	101/488 (21%)
		PTPc	1298..1525	CDD:238006	91/447 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443525
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19134
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030