DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTP-ER and Ptpmeg2

DIOPT Version :9

Sequence 1:	NP_726092.1	Gene:	PTP-ER / 37461	FlyBaseID:	FBgn0016641	Length:	1377	Species:	Drosophila melanogaster
Sequence 2:	NP_572576.1	Gene:	Ptpmeg2 / 31907	FlyBaseID:	FBgn0028341	Length:	827	Species:	Drosophila melanogaster

Alignment Length:	1063	Identity:	217/1063 - (20%)
Similarity:	316/1063 - (29%)	Gaps:	426/1063 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   420 HCSSTT---QSSLDSDASLT--------PSLGDFELKSACSVDGGSK-----FGIGASLAPRSAH 468
            :||:||   .|:..|.||.|        |.|...:::......||..     .|.|...||...|
  Fly    53 NCSTTTATSPSTSSSSASSTQNLIAVVPPQLQQLQVQLPAPGGGGGAGAGGGGGGGGGAAPVRRH 117

  Fly   469 KHNQLLHSSSTNLK-----TLPECLTLVEFSSS--------GGGPKESPFKQKSMDLPMPTLQAK 520
                :.|:::....     .:|..::|.|....        ...|...|.:.:........|.|:
  Fly   118 ----ISHTTAVKFLYARKFDIPRAVSLYEQHEQIRLKEYLYNIDPDVEPLRSELQTGKFTILPAR 178

  Fly   521 TTVSTSSMNLLQRRGS----NHSLTL-----NLHSSCGNLMN-----------SGLSHSNYSLGS 565
            |:...:.......|.|    :|:.||     .|.|:..:...           ||..:||:...
  Fly   179 TSSGAAIALFTANRHSPLSVSHTTTLQGIVYQLDSALQDSETQRAGLVFIYDMSGSKYSNFDYD- 242

  Fly   566 ILNSKSSCNLDAGTASQIRADQLPQSHLLGSSQGSRQGLFRRRGSNHSI---------------- 614
             |:.|....|..|..::::...:..:.|...:......||.|......:
  Fly   243 -LSQKILTLLKGGYPARLKKVLIVTAPLWFKAPFKILRLFVREKLRERVFTVSVPQLALHVPRKA 306

  Fly   615 -------TLKTGHTT--TSCGDLNSMQQLQQQQAMLSAEKYNRLNMRTNSTGSGSGSGSNVPTPK 670
                   ||:..|.|  .||           :|:|.:.|.    .:..|..|.|.||||
  Fly   307 LPIHLGGTLEVDHATWLLSC-----------RQSMTNRED----ELLANIVGVGGGSGS------ 350

  Fly   671 RGLLERRGSNQSLTLNMGSILGGAA-----GTEIQMTDIVQPKVTVCSCAAANQAPHQRKFFSTE 730
                             ||..|.||     |||   |:......|:.|      |.||....:|.
  Fly   351 -----------------GSAAGSAAIVSTNGTE---TEAATTAATIIS------AVHQLGDNNTT 389

  Fly   731 NLNSSKANSQKFFGQVCFGSASDLQPNPQQDSVREDQAIGATCTCAGTV---RNIMTRPLSP--- 789
            .:..|.       |....||||.                |||...:...   .||....|||
  Fly   390 VVTVSN-------GVGPAGSASG----------------GATTAASAATEPNENITINGLSPSHR 431

  Fly   790 QTTSEEFKIYLASIQMLQSASNPLNQFDLIRLNYVFDHSYQTNRNIIEQPPVLGSNARDVETPTD 854
            |..:..    .:|.....:.:|||      :||  ...|...|..|.......|:......|.|:
  Fly   432 QAANNS----SSSSSSAATVANPL------KLN--TSGSADNNSTITNATTAAGAAGAAAGTTTN 484

  Fly   855 -------MVPPSS-----EDSELLASYQTVVSRMAQPIPELKENEQKRIFRDLHKEFWDLPLNHQ 907
                   ..||||     .|.:.||..:    ...:||.::.:..::|....|.||:.|:.....
  Fly   485 GGGEFWSENPPSSASSGFSDDDSLAGQE----GDPKPIDQIVQMVKQRGRHGLIKEYADIRNRAP 545

  Fly   908 EKPMVF----GSQTKNRYKTILPNENSRVLLESESSELTSLLGEIKRTSSVTASEDLPYINANYI 968
            |...:.    .:.|||||..:|..::|||:|..|..:                 |...|||||::
  Fly   546 EGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGD-----------------EPSDYINANFV 593

  Fly   969 KGPDYVSK-CYVATQGPLPNTIFEFWLMIYQNTQRYIRRCVDGGSSSSPHVDREQILQQYFQKIV 1032
            .|  |..| .|::||||||.|..:||.||:                           :|:...||
  Fly   594 DG--YKQKNAYISTQGPLPKTSQDFWRMIW---------------------------EQHCLVIV 629

  Fly  1033 MLTNFTEANRQKCAVYF-PIELNEIFAVAAKCEVFQLSAAARDYFDRYLTPTFVPDTVVASSDAI 1096
            |.|...|..|.||..|: |.|              :.|....||..|.::.....|.:|||.:.
  Fly   630 MTTRVMERGRVKCGQYWEPTE--------------ESSLEFGDYHVRTISVECNEDYMVASLEL- 679

  Fly  1097 DYEISGRHIGVESVKVTLEGDLLEALPAQGSFFLIKNVGIVRRNGYSVRKLVLLYCIRVPQSASY 1161
                  |:|..:.                     |:||.
  Fly   680 ------RNIKTDE---------------------IRNVS-------------------------- 691

  Fly  1162 HLQKIYCYHYWYPDWPDHHSPRDINTLLDTCLHVLNLGKCESEFDIYDDTRSERNAHLAAQRLEI 1226
                    |:.:..|||:..|.....:|:....|                 .|:.|.|
  Fly   692 --------HWQFTSWPDYGVPSSAMAMLNFLQKV-----------------REKQAQL------- 724

  Fly  1227 YQQDIFNAVQ------------PLPVIHCSAGIGRTGCFTAILNAVRQLRQSLAYSLTGMLTKSL 1279
                    ||            |..|:||||||||||.|..:...:.:|
  Fly   725 --------VQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRL---------------- 765

  Fly  1280 TSSSTEEYHNPTDSDSSFTCNTIRHISHILDHRDAEAVKTPPSFDRLPKMPDIFVDVLGIVCNLR 1344
                                               |.|.|              .|:.|.|..:|
  Fly   766 -----------------------------------EDVGT--------------ADIRGTVEKIR 781

  Fly  1345 LQRGGMVQNSEQYELIHRAICLY 1367
            .||...:|..:||...|.|:..|
  Fly   782 SQRAYSIQMPDQYVFCHLALIEY 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	Y_phosphatase	916..1364	CDD:278528	96/461 (21%)
PTP-ER	NP_726092.1	PTPc	917..1364	CDD:238006	96/460 (21%)
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024	5/33 (15%)
		SEC14	170..314	CDD:238099	22/145 (15%)
		Y_phosphatase	557..803	CDD:278528	97/464 (21%)
		PTPc	559..803	CDD:238006	97/462 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443560
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19134
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030