Protein Alignment PTP-ER and Ptpmeg2

DIOPT Version :10

• Sequence 1: NP_726092.1
• Gene: PTP-ER / 37461
• FlyBaseID: FBgn0016641
• Length: 1377
• Species: Drosophila melanogaster
• Sequence 2: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Alignment Length: 1063
• Identity: 217/1063 - (20%)
• Similarity: 316/1063 - (29%)
• Gaps: 426/1063 - (40%)

  Fly   420 HCSSTT---QSSLDSDASLT--------PSLGDFELKSACSVDGGSK-----FGIGASLAPRSAH 468
            :||:||   .|:..|.||.|        |.|...:::......||..     .|.|...||...|
  Fly    53 NCSTTTATSPSTSSSSASSTQNLIAVVPPQLQQLQVQLPAPGGGGGAGAGGGGGGGGGAAPVRRH 117

  Fly   469 KHNQLLHSSSTNLK-----TLPECLTLVEFSSS--------GGGPKESPFKQKSMDLPMPTLQAK 520
                :.|:::....     .:|..::|.|....        ...|...|.:.:........|.|:
  Fly   118 ----ISHTTAVKFLYARKFDIPRAVSLYEQHEQIRLKEYLYNIDPDVEPLRSELQTGKFTILPAR 178

  Fly   521 TTVSTSSMNLLQRRGS----NHSLTL-----NLHSSCGNLMN-----------SGLSHSNYSLGS 565
            |:...:.......|.|    :|:.||     .|.|:..:...           ||..:||:...
  Fly   179 TSSGAAIALFTANRHSPLSVSHTTTLQGIVYQLDSALQDSETQRAGLVFIYDMSGSKYSNFDYD- 242

  Fly   566 ILNSKSSCNLDAGTASQIRADQLPQSHLLGSSQGSRQGLFRRRGSNHSI---------------- 614
             |:.|....|..|..::::...:..:.|...:......||.|......:
  Fly   243 -LSQKILTLLKGGYPARLKKVLIVTAPLWFKAPFKILRLFVREKLRERVFTVSVPQLALHVPRKA 306

  Fly   615 -------TLKTGHTT--TSCGDLNSMQQLQQQQAMLSAEKYNRLNMRTNSTGSGSGSGSNVPTPK 670
                   ||:..|.|  .||           :|:|.:.|.    .:..|..|.|.||||
  Fly   307 LPIHLGGTLEVDHATWLLSC-----------RQSMTNRED----ELLANIVGVGGGSGS------ 350

  Fly   671 RGLLERRGSNQSLTLNMGSILGGAA-----GTEIQMTDIVQPKVTVCSCAAANQAPHQRKFFSTE 730
                             ||..|.||     |||   |:......|:.|      |.||....:|.
  Fly   351 -----------------GSAAGSAAIVSTNGTE---TEAATTAATIIS------AVHQLGDNNTT 389

  Fly   731 NLNSSKANSQKFFGQVCFGSASDLQPNPQQDSVREDQAIGATCTCAGTV---RNIMTRPLSP--- 789
            .:..|.       |....||||.                |||...:...   .||....|||
  Fly   390 VVTVSN-------GVGPAGSASG----------------GATTAASAATEPNENITINGLSPSHR 431

  Fly   790 QTTSEEFKIYLASIQMLQSASNPLNQFDLIRLNYVFDHSYQTNRNIIEQPPVLGSNARDVETPTD 854
            |..:..    .:|.....:.:|||      :||  ...|...|..|.......|:......|.|:
  Fly   432 QAANNS----SSSSSSAATVANPL------KLN--TSGSADNNSTITNATTAAGAAGAAAGTTTN 484

  Fly   855 -------MVPPSS-----EDSELLASYQTVVSRMAQPIPELKENEQKRIFRDLHKEFWDLPLNHQ 907
                   ..||||     .|.:.||..:    ...:||.::.:..::|....|.||:.|:.....
  Fly   485 GGGEFWSENPPSSASSGFSDDDSLAGQE----GDPKPIDQIVQMVKQRGRHGLIKEYADIRNRAP 545

  Fly   908 EKPMVF----GSQTKNRYKTILPNENSRVLLESESSELTSLLGEIKRTSSVTASEDLPYINANYI 968
            |...:.    .:.|||||..:|..::|||:|..|..:                 |...|||||::
  Fly   546 EGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHEDGD-----------------EPSDYINANFV 593

  Fly   969 KGPDYVSK-CYVATQGPLPNTIFEFWLMIYQNTQRYIRRCVDGGSSSSPHVDREQILQQYFQKIV 1032
            .|  |..| .|::||||||.|..:||.||:                           :|:...||
  Fly   594 DG--YKQKNAYISTQGPLPKTSQDFWRMIW---------------------------EQHCLVIV 629

  Fly  1033 MLTNFTEANRQKCAVYF-PIELNEIFAVAAKCEVFQLSAAARDYFDRYLTPTFVPDTVVASSDAI 1096
            |.|...|..|.||..|: |.|              :.|....||..|.::.....|.:|||.:.
  Fly   630 MTTRVMERGRVKCGQYWEPTE--------------ESSLEFGDYHVRTISVECNEDYMVASLEL- 679

  Fly  1097 DYEISGRHIGVESVKVTLEGDLLEALPAQGSFFLIKNVGIVRRNGYSVRKLVLLYCIRVPQSASY 1161
                  |:|..:.                     |:||.
  Fly   680 ------RNIKTDE---------------------IRNVS-------------------------- 691

  Fly  1162 HLQKIYCYHYWYPDWPDHHSPRDINTLLDTCLHVLNLGKCESEFDIYDDTRSERNAHLAAQRLEI 1226
                    |:.:..|||:..|.....:|:....|                 .|:.|.|
  Fly   692 --------HWQFTSWPDYGVPSSAMAMLNFLQKV-----------------REKQAQL------- 724

  Fly  1227 YQQDIFNAVQ------------PLPVIHCSAGIGRTGCFTAILNAVRQLRQSLAYSLTGMLTKSL 1279
                    ||            |..|:||||||||||.|..:...:.:|
  Fly   725 --------VQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRL---------------- 765

  Fly  1280 TSSSTEEYHNPTDSDSSFTCNTIRHISHILDHRDAEAVKTPPSFDRLPKMPDIFVDVLGIVCNLR 1344
                                               |.|.|              .|:.|.|..:|
  Fly   766 -----------------------------------EDVGT--------------ADIRGTVEKIR 781

  Fly  1345 LQRGGMVQNSEQYELIHRAICLY 1367
            .||...:|..:||...|.|:..|
  Fly   782 SQRAYSIQMPDQYVFCHLALIEY 804

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	PTP_DSP_cys	919..1362	CDD:475123	93/456 (20%)
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024	5/33 (15%)
		SEC14	170..314	CDD:469559	22/145 (15%)
		PTPc-N9	529..799	CDD:350391	100/488 (20%)