DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTP-ER and Ptp4E

DIOPT Version :9

Sequence 1:	NP_726092.1	Gene:	PTP-ER / 37461	FlyBaseID:	FBgn0016641	Length:	1377	Species:	Drosophila melanogaster
Sequence 2:	NP_001162669.1	Gene:	Ptp4E / 31425	FlyBaseID:	FBgn0004368	Length:	1767	Species:	Drosophila melanogaster

Alignment Length:	1723	Identity:	311/1723 - (18%)
Similarity:	506/1723 - (29%)	Gaps:	716/1723 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 PLEAGEDAESNKSTPYFTPLEYLQTSFEFPSPTVEVGGG--VPGFPEHEDQEEEVFTPRQFTI-- 94
            |.|.....|.|         |.||.|.:..:|    ||.  |..:..::.:|...:|.|.||.
  Fly   193 PFERSYSLEGN---------ETLQLSAKELTP----GGSYQVQAYSVYQGKESVAYTSRNFTTKP 244

  Fly    95 --------------------TSPHPAAHVHHPSSSQSPTLGRKFKRLSQYDRRSCSPHINTSSGE 139
                                ..|.||....|...|.:|  ....:.:...:|....|....::.:
  Fly   245 NTPGKFIVWFRNETTLLVLWQPPFPAGIYTHYRVSITP--DDAIQSVLYVEREGEPPGPAQAAFK 307

  Fly   140 ERVSGRGIDKENTMPKGGSVDQDLENSL-----YLSKSEHNSPTILFKDESSTTPGLEASRLSYS 199
            ..|.||   :.|...:  :|.:|..:|:     ||:..| ....:.| ||:.||.  .:.|:.:.
  Fly   308 GLVPGR---EYNISVQ--TVSEDETSSVPTTARYLTVPE-RVLNVTF-DEAYTTS--SSFRVRWE 363

  Fly   200 -PKLLSSINNLNVS-GSPLNIINSAGYKNGN--FFRFPEI------DHVVQDAPMDTV----CLE 250
             |:..|..:...|. .:...|.|.....||:  :|.:|:|      ..||.....|.|    ...
  Fly   364 PPRTYSEFDAYQVMLSTSRRIFNVPRAANGDSVYFDYPDILEPGRTYEVVVKTIADNVNSWPASG 428

  Fly   251 EATRR------------DRSPALA---EPPEQQQQKSEGRKNRKNKN--------------NLTI 286
            |.|.|            |||.||.   ||.|..:|.|......:..|              .:|.
  Fly   429 EVTLRPRPVRSLGGFLDDRSNALHISWEPAETGRQDSYRISYHEQTNASEVPAPFPVAAESQITT 493

  Fly   287 RITDVPI---------------------KNSSQPSPLPKPKTPTIKSTKEKARSLDS-------- 322
            .:|:..:                     .|:|..:...:|..|.|    ::.||:|.
  Fly   494 NLTEYTLDSLLAGRRYLIAVQALSKGVASNASDITRYTRPAAPLI----QELRSIDQGLMLSWRS 554

  Fly   323 ------------------------AANESELSI-----------VVHNITESHGSCDDMETGQSQ 352
                                    |.||:.|:|           .||.|  |||.       :|:
  Fly   555 DVNSRQDRYEVHYQRNGTREERTMATNETSLTIHYLHPGSGYEVKVHAI--SHGV-------RSE 610

  Fly   353 P---------------STSVIHHH---LHLQQPASAIHSTSLSRLDSHLSLANQRRTPRRKSPGI 399
            |               :...:|.:   ||.|.|..:..|..:.|..:..|       |.::..|:
  Fly   611 PHSYFQAVFPKPPQNLTLQTVHTNLVVLHWQAPEGSDFSEYVVRYRTDAS-------PWQRISGL 668

  Fly   400 NTTDWLMYHRKQNPYQVQPTHCSSTTQSSLDSDASLTPSLGDFELKSACSVDGGSKFGIGASLAP 464
            :          :|..:::..|........::     |.|.|         |:......:..::.|
  Fly   669 H----------ENEARIKDMHYGERYLVQVN-----TVSFG---------VESPHPLELNVTMPP 709

  Fly   465 RSAHKHNQLLHSSSTNLKTLPECLTLVEFSSSGGGPKES----PFKQKSM--DLPMPTLQ----- 518
            :.......|:.|.:..|: .|.....|:|.:....|.:.    .||..:.  ||..|:::
  Fly   710 QPVSNVVPLVDSRNLTLE-WPRPDGHVDFYTLKWWPTDEEDRVEFKNVTQLEDLSSPSVRIPIED 773

  Fly   519 --------------------AKTTVSTSSMNLLQ----------RRGSNHSLTLNL--------- 544
                                ..|.:||.:|.|:|          .:|.:.::||:.
  Fly   774 LSPGRQYRFEVQASSNGIRSGTTHLSTRTMPLIQSDVFIANAGHEQGQDETITLSYTPTPADSTR 838

  Fly   545 ---------------HSSCGNLMNSGLSHSNYSLGSILNSKSSCNLDAGTAS-----QIRADQLP 589
                           .....|.....||.|..:.|.:.| .:...:..|.||     ..|...||
  Fly   839 FDIYRFSMGDPTIKDKEKLANDTERKLSFSGLTPGKLYN-VTVWTVSGGVASLPVQRLYRLHPLP 902

  Fly   590 QSHLLGSSQGSRQGLFRRRGSNHSITLKTGHTTTSCGDLN--SMQQL----QQQQAMLSAEKYNR 648
            .|.|......:|:           |||   |.|...|:..  .:|.|    :..|.:.:..|...
  Fly   903 ISDLKAIQVAARE-----------ITL---HWTAPAGEYTDFELQYLSADEEAPQLLQNVTKNTE 953

  Fly   649 LNMR----------TNSTGSGSGSGS-----NVPTPKRGLLERRGSNQSLTLNMGSILGGAAGTE 698
            :.::          |....|||..|:     :|.|..|.......|.|:||...|.:      ..
  Fly   954 ITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTLTAPPGKV------DY 1012

  Fly   699 IQMTDIVQPKVTV-CSCAAANQ-APHQRKFFSTENL-NSSKANSQKFFGQVCFGSASDLQP-NPQ 759
            .|.:|:...:||. .|...|.| .|......:.:|. :::..:|.:|......|....|.| |..
  Fly  1013 FQPSDVQPGEVTFEWSLEPAEQHGPIDYFRITCQNADDAADVSSYEFPVNATQGKIDGLVPGNHY 1077

  Fly   760 QDSVREDQAIGATCTCAGTVR-NIMTRPL------SPQTTSEEFKIYLASIQMLQSASNPLNQFD 817
            ...::...|:|     .|..| :|.|.|:      .|..|..|.....::|::........|...
  Fly  1078 IFRIQAKSALG-----YGAEREHIQTMPILAPPVPEPSVTPLEVSRTSSTIEISFRQGYFSNAHG 1137

  Fly   818 LIRLNYVFDHSYQTNRNI--IEQP---------------------PVLGSNA------------- 846
            ::| :|....:....:|.  :|.|                     |.|.||.
  Fly  1138 MVR-SYTIIIAEDVGKNASGLEMPSWQDVQAYTVWLPYQAIEPYNPFLTSNGSRKSSLEAEHFTI 1201

  Fly   847 ------------------------------RDVETPTDMV---PPSSEDSELLASYQTV------ 872
                                          .|.:..||.|   |.::|.|:.:....||
  Fly  1202 GTANCDKHQAGYCNGPLRAGTTYRIKIRAFTDEDKFTDTVYSSPITTERSDTVIVAATVSAVLLV 1266

  Fly   873 ---------------------VSRMAQPIPELKE------------------------------- 885
                                 ::||...:..|.|
  Fly  1267 AMVLVVVYCQHRCQLIRRASKLARMQDELAALPEGYITPNRPVHVKDFSEHYRIMSADSDFRFSE 1331

  Fly   886 --NEQKRIFRDLHKEFWDLPLNHQEKPMVFGSQTKNRYKTILPNENSRVLLESESSELTSLLGEI 948
              .|.|.:.||....|.:||.|          :.|||:..|||.::||..|:
  Fly  1332 EFEELKHVGRDQACSFANLPCN----------RPKNRFTNILPYDHSRFKLQ------------- 1373

  Fly   949 KRTSSVTASEDLPYINANYIKGPDYVSKCYVATQGPLPNTIFEFWLMIYQNTQRYIRRCVDGGSS 1013
                .|...:...||||||:.|.:...: ::.|||||.:|..|||.|.:::..|
  Fly  1374 ----PVDDDDGSDYINANYMPGHNSPRE-FIVTQGPLHSTREEFWRMCWESNSR----------- 1422

  Fly  1014 SSPHVDREQILQQYFQKIVMLTNFTEANRQKCAVYFPIELNEIFAVAAKCEVFQLSAAARDYFDR 1078
                            .|||||...|..|:||..|:|::...:|                 |.|
  Fly  1423 ----------------AIVMLTRCFEKGREKCDQYWPVDRVAMF-----------------YGD- 1453

  Fly  1079 YLTPTFVPDTVVASSDAIDYEISGRHIGVESVKVTLEGDLLEALPAQGSFFLIKNV--GIVRRNG 1141
                  :...::..:...|:.||                         .|.:.:|.  .|:|
  Fly  1454 ------IKVQLIIDTHYHDWSIS-------------------------EFMVSRNCESRIMR--- 1484

  Fly  1142 YSVRKLVLLYCIRVPQSASYHLQKIYCYHYWYPDWPDHHSPRDINTLLDTCLHVLNLGKCESEFD 1206
                                        |:.:..|||...|....:|:
  Fly  1485 ----------------------------HFHFTTWPDFGVPEPPQSLV----------------- 1504

  Fly  1207 IYDDTRSERNAHLAAQRLEIYQQDIFNAVQPLPVIHCSAGIGRTGCFTAILNAVRQLRQSLAYSL 1271
                           :.:..::..|...::|: ::|||||:||:|.|.|:
  Fly  1505 ---------------RFVRAFRDVIGTDMRPI-IVHCSAGVGRSGTFIAL--------------- 1538

  Fly  1272 TGMLTKSLTSSSTEEYHNPTDSDSSFTCNTIRHISHILDHRDAEAVKTPPSFDRLPKMPDIFVDV 1336
                                          .|.:.||  |:..                  :||:
  Fly  1539 ------------------------------DRILQHI--HKSD------------------YVDI 1553

  Fly  1337 LGIVCNLRLQRGGMVQNSEQYELIHRAICLYLK 1369
            .|||..:|.:|..|||..:||..||:.:...|:
  Fly  1554 FGIVFAMRKERVFMVQTEQQYVCIHQCLLAVLE 1586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	Y_phosphatase	916..1364	CDD:278528	85/449 (19%)
PTP-ER	NP_726092.1	PTPc	917..1364	CDD:238006	85/448 (19%)
Ptp4E	NP_001162669.1	FN3	151..242	CDD:238020	16/61 (26%)
		fn3	247..328	CDD:278470	14/87 (16%)
		fn3	343..417	CDD:278470	18/76 (24%)
		fn3	443..525	CDD:278470	14/81 (17%)
		FN3	548..611	CDD:238020	12/71 (17%)
		FN3	620..706	CDD:238020	16/116 (14%)
		fn3	708..796	CDD:278470	13/88 (15%)
		fn3	824..886	CDD:278470	8/62 (13%)
		fn3	902..978	CDD:278470	18/89 (20%)
		fn3	1013..1092	CDD:278470	18/83 (22%)
		UP_III_II	1106..>1248	CDD:297589	19/142 (13%)
		PTPc	1329..1582	CDD:214550	93/485 (19%)
		PTPc	1355..1582	CDD:238006	85/449 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443526
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19134
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030