Protein Alignment PTP-ER and Ptpn5

DIOPT Version :10

• Sequence 1: NP_726092.1
• Gene: PTP-ER / 37461
• FlyBaseID: FBgn0016641
• Length: 1377
• Species: Drosophila melanogaster
• Sequence 2: XP_038965611.1
• Gene: Ptpn5 / 29644
• RGDID: 3448
• Length: 613
• Species: Rattus norvegicus
• Alignment Length: 1022
• Identity: 213/1022 - (20%)
• Similarity: 313/1022 - (30%)
• Gaps: 489/1022 - (47%)

  Fly   421 CSSTTQSSLDSDASLTPSLGD-------FELKSACSVDGG------SKFGIGASLAPRSAHK--- 469
            |:|::.|...|.:|||...||       .|.::|....||      ||..:|....|....:
  Rat     2 CTSSSSSLSSSSSSLTKESGDRMAQWSEKESQAADDSKGGTLDMCCSKRLLGWQHGPPVGDQIPG 66

  Fly   470 HNQLLHS--SSTNLKTLPECLTLVEFSSSGGGPKES---PFKQKSMDLPMPTLQAKTTVSTSSMN 529
            .::||..  |:.:.|.||:.:.:       ||..|.   |.||:.:..|.|     :..|..:..
  Rat    67 QDKLLSKKRSTEDSKGLPQPVEM-------GGLDEGEGLPSKQRELPPPPP-----SPPSEPAQK 119

  Fly   530 LLQRRGSNHSLTL----------NLHSSCGNLMNSGLSHS--NYSLGSILNSKSSCNLDAGTASQ 582
            |..:...:||||:          .|..:||.|..||..||  ..:...|.:|.:..|
  Rat   120 LPPQGAGSHSLTVRSSLCLFAASQLLLACGVLWLSGHGHSWLQTTTDLIFSSLTVLN-------- 176

  Fly   583 IRADQLPQSHLLGSSQGSRQGLFRRRGSNHSITLKTGHTTTSCGDL--------------NSMQQ 633
                .|..:..|||.......|..     .|:|:..|..||....|              :..|.
  Rat   177 ----HLGPAAWLGSGTWGTPSLLL-----VSLTVSLGIITTLVWHLLKTPPEPPVPLPPEDRRQS 232

  Fly   634 LQQQQAMLSAEKYNR---------------------LNMRTNSTGSGSGSGSNVPTPKRGLLERR 677
            :.:|.:...:|....                     ::::..:      ..:::.....||.|||
  Rat   233 VSRQPSFTYSEWMEEKVEDDFLDLDAVPETPVFDCVMDIKPEA------DPTSLTVKSMGLQERR 291

  Fly   678 GSNQSLTLNMGSILGGAAGTEIQMTDIVQPKVTVCS--CAAANQAPHQRKFFSTENLNSSKANSQ 740
            |||.||||:|                        |:  |                        ::
  Rat   292 GSNVSLTLDM------------------------CTPGC------------------------NE 308

  Fly   741 KFFGQVCFGSASDLQPNPQQDSVREDQAIGATCTCAGTVRNIMTRPLSPQTTSEEFKIYLASIQM 805
            :.||.:.         :|:::|..|                                       .
  Rat   309 EGFGYLV---------SPREESAHE---------------------------------------Y 325

  Fly   806 LQSASNPLNQFDLIRLNYVFDHSYQTNRNIIEQPPVLGSNARDVETPTDMVPPSSEDSELLASYQ 870
            |.|||..|...:|        |....:..:::        |...|.|.:.|.|
  Rat   326 LLSASRVLRAEEL--------HEKALDPFLLQ--------AEFFEIPMNFVDP------------ 362

  Fly   871 TVVSRMAQPIPELKENEQKRIFRDLHKEFWDLPLNHQEKPMVFGSQTKNRYKTILPNENSRVLLE 935
                                      ||: |:|          |...||||||||||.:|||.|.
  Rat   363 --------------------------KEY-DIP----------GLVRKNRYKTILPNPHSRVRLT 390

  Fly   936 SESSE--LTSLLGEIKRTSSVTASEDLPYINANYIKGPDYVSKCYVATQGPLPNTIFEFWLMIYQ 998
            |...|  |:|                  |||||||:|.:...|.|:|||||:.:|:.:||.|::|
  Rat   391 SPDPEDPLSS------------------YINANYIRGYNGEEKVYIATQGPIVSTVADFWRMVWQ 437

  Fly   999 NTQRYIRRCVDGGSSSSPHVDREQILQQYFQKIVMLTNFTEANRQKCAVYFPIELNEIFAVAAKC 1063
                                :|..|       |||:||..|.| :||..|:|.|
  Rat   438 --------------------ERTPI-------IVMITNIEEMN-EKCTEYWPEE----------- 463

  Fly  1064 EVFQLSAAARDYFDRYLTPTFVPDTVVASSDAIDYEISGRHIGVESVKVTLEGDLLEALPAQGSF 1128
                                    .||             |.|||   :|::
  Rat   464 ------------------------QVV-------------HDGVE---ITVQ------------- 475

  Fly  1129 FLIKNVGIVRRNGYSVRKLVLLYCIRVPQSASYHLQKIYCYHYWYPDWPDHHSPRDINTLLDTCL 1193
                  .::....|.:|.:          |.....::....|||:..|||..:|.....||
  Rat   476 ------KVIHTEDYRLRLI----------SLRRGTEERGLKHYWFTSWPDQKTPDRAPPLL---- 520

  Fly  1194 HVLNLGKCESEFDIYDDTRSERNAHLAAQRLEIYQQDIFNAVQPLPVIHCSAGIGRTGCFTAILN 1258
                                    ||..:..|..||:..:. .|: ::||||||||||||.|
  Rat   521 ------------------------HLVREVEEAAQQEGPHC-SPI-IVHCSAGIGRTGCFIA--- 556

  Fly  1259 AVRQLRQSLAYSLTGMLTKSLTSSSTEEYHNPTDSDSSFTCNTIRHISHILDHRDAEAVKTPPSF 1323
                                                :|..|..:|.          |.|
  Rat   557 ------------------------------------TSICCQQLRR----------EGV------ 569

  Fly  1324 DRLPKMPDIFVDVLGIVCNLRLQRGGMVQNSEQYELIHRAICLYLKR 1370
                      ||:|...|.||..||||:|..|||:.:|.|:.||.|:
  Rat   570 ----------VDILKTTCQLRQDRGGMIQTCEQYQFVHHAMSLYEKQ 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	PTP_DSP_cys	919..1362	CDD:475123	108/444 (24%)
Ptpn5	XP_038965611.1	PTPc-N5	346..603	CDD:350461	121/534 (23%)