Protein Alignment PTP-ER and PTPN22

DIOPT Version :9

• Sequence 1: NP_726092.1
• Gene: PTP-ER / 37461
• FlyBaseID: FBgn0016641
• Length: 1377
• Species: Drosophila melanogaster
• Sequence 2: NP_057051.3
• Gene: PTPN22 / 26191
• HGNCID: 9652
• Length: 807
• Species: Homo sapiens
• Alignment Length: 509
• Identity: 115/509 - (22%)
• Similarity: 165/509 - (32%)
• Gaps: 236/509 - (46%)

  Fly   883 LKENEQKRIFR-DLHKEFWDL-------------PLNHQEKPMVFGSQTKNRYKTILPNENSRVL 933
            |.|.:.|:|.: :...||..|             |....|||.   :..|||||.|||.:.|||.
Human    11 LDEAQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAEKPK---NIKKNRYKDILPYDYSRVE 72

  Fly   934 LESESSELTSLLGEIKRTSSVTASEDLPYINANYIKGPDYVSKCYVATQGPLPNTIFEFWLMIYQ 998
            |                 |.:|:.||..|||||:|||. |..|.|:||||||..|:.:||.||::
Human    73 L-----------------SLITSDEDSSYINANFIKGV-YGPKAYIATQGPLSTTLLDFWRMIWE 119

  Fly   999 NTQRYIRRCVDGGSSSSPHVDREQILQQYFQKIVMLTNFTEANRQKCAVYFPIELNEIFAVAAKC 1063
            .:...                           |||.....|..::||..|:
Human   120 YSVLI---------------------------IVMACMEYEMGKKKCERYW-------------- 143

  Fly  1064 EVFQLSAAARDYFDRYLTPTFVPDTVVASSDAIDYEISGRHIGVESVKVTLEGDLLEALPAQGSF 1128
                                       |....:..|.....:..|:.|
Human   144 ---------------------------AEPGEMQLEFGPFSVSCEAEK----------------- 164

  Fly  1129 FLIKNVGIVRRNGYSVRKLVLLYCIRVPQSASYHLQKIYCYHYWYPDWPDHHSPRDINTLLDTCL 1193
                     |::.|.:|.|.:.:        :...:.||.:|  |.:||||..|..|:.:|:.
Human   165 ---------RKSDYIIRTLKVKF--------NSETRTIYQFH--YKNWPDHDVPSSIDPILEL-- 208

  Fly  1194 HVLNLGKCESEFDIYDDTRSERNAHLAAQRLEIYQQDIFNAVQPLPV-IHCSAGIGRTGCFTAIL 1257
                         |:|              :..||:|     ..:|: ||||||.||||...||
Human   209 -------------IWD--------------VRCYQED-----DSVPICIHCSAGCGRTGVICAI- 240

  Fly  1258 NAVRQLRQSLAYSLTGMLTKSLTSSSTEEYHNPTDSDSSFTCNTIRHISHILDHRDAEAVKTPPS 1322
                        ..|.||.|
Human   241 ------------DYTWMLLK--------------------------------------------- 248

  Fly  1323 FDRLPKMPDIFVDVLGIVCNLRLQRGGMVQNSEQYELIHRAICLYLKRTLALRR 1376
             |.:  :|:.| .|..::..:|.||..:||..|||||::.|:....||.:.:.|
Human   249 -DGI--IPENF-SVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMDVIR 298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	Y_phosphatase	916..1364	CDD:278528	100/448 (22%)
		PTPc	917..1364	CDD:238006	100/447 (22%)
PTPN22	NP_057051.3	PTPc	24..288	CDD:214550	108/484 (22%)
		PTPc	56..288	CDD:238006	101/449 (22%)
		Substrate binding	227..233		4/5 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	676..700
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	724..746

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900