DRSC/TRiP Functional Genomics Resources

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Protein Alignment PTP-ER and PTPN22

DIOPT Version :10

Sequence 1:NP_726092.1 Gene:PTP-ER / 37461 FlyBaseID:FBgn0016641 Length:1377 Species:Drosophila melanogaster
Sequence 2:NP_057051.4 Gene:PTPN22 / 26191 HGNCID:9652 Length:807 Species:Homo sapiens


Alignment Length:509 Identity:115/509 - (22%)
Similarity:165/509 - (32%) Gaps:236/509 - (46%)


- Green bases have known domain annotations that are detailed below.


  Fly   883 LKENEQKRIFR-DLHKEFWDL-------------PLNHQEKPMVFGSQTKNRYKTILPNENSRVL 933
            |.|.:.|:|.: :...||..|             |....|||.   :..|||||.|||.:.|||.
Human    11 LDEAQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAEKPK---NIKKNRYKDILPYDYSRVE 72

  Fly   934 LESESSELTSLLGEIKRTSSVTASEDLPYINANYIKGPDYVSKCYVATQGPLPNTIFEFWLMIYQ 998
            |                 |.:|:.||..|||||:|||. |..|.|:||||||..|:.:||.||::
Human    73 L-----------------SLITSDEDSSYINANFIKGV-YGPKAYIATQGPLSTTLLDFWRMIWE 119

  Fly   999 NTQRYIRRCVDGGSSSSPHVDREQILQQYFQKIVMLTNFTEANRQKCAVYFPIELNEIFAVAAKC 1063
            .:...                           |||.....|..::||..|:              
Human   120 YSVLI---------------------------IVMACMEYEMGKKKCERYW-------------- 143

  Fly  1064 EVFQLSAAARDYFDRYLTPTFVPDTVVASSDAIDYEISGRHIGVESVKVTLEGDLLEALPAQGSF 1128
                                       |....:..|.....:..|:.|                 
Human   144 ---------------------------AEPGEMQLEFGPFSVSCEAEK----------------- 164

  Fly  1129 FLIKNVGIVRRNGYSVRKLVLLYCIRVPQSASYHLQKIYCYHYWYPDWPDHHSPRDINTLLDTCL 1193
                     |::.|.:|.|.:.:        :...:.||.:|  |.:||||..|..|:.:|:.  
Human   165 ---------RKSDYIIRTLKVKF--------NSETRTIYQFH--YKNWPDHDVPSSIDPILEL-- 208

  Fly  1194 HVLNLGKCESEFDIYDDTRSERNAHLAAQRLEIYQQDIFNAVQPLPV-IHCSAGIGRTGCFTAIL 1257
                         |:|              :..||:|     ..:|: ||||||.||||...|| 
Human   209 -------------IWD--------------VRCYQED-----DSVPICIHCSAGCGRTGVICAI- 240

  Fly  1258 NAVRQLRQSLAYSLTGMLTKSLTSSSTEEYHNPTDSDSSFTCNTIRHISHILDHRDAEAVKTPPS 1322
                        ..|.||.|                                             
Human   241 ------------DYTWMLLK--------------------------------------------- 248

  Fly  1323 FDRLPKMPDIFVDVLGIVCNLRLQRGGMVQNSEQYELIHRAICLYLKRTLALRR 1376
             |.:  :|:.| .|..::..:|.||..:||..|||||::.|:....||.:.:.|
Human   249 -DGI--IPENF-SVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMDVIR 298

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PTP-ERNP_726092.1 PTP_DSP_cys 919..1362 CDD:475123 99/443 (22%)
PTPN22NP_057051.4 PTPc-N22 57..290 CDD:350450 101/450 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 676..700
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 724..746
Blue background indicates that the domain is not in the aligned region.

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