Protein Alignment PTP-ER and PTPN20

DIOPT Version :9

• Sequence 1: NP_726092.1
• Gene: PTP-ER / 37461
• FlyBaseID: FBgn0016641
• Length: 1377
• Species: Drosophila melanogaster
• Sequence 2: NP_001035816.1
• Gene: PTPN20 / 26095
• HGNCID: 23423
• Length: 420
• Species: Homo sapiens
• Alignment Length: 672
• Identity: 136/672 - (20%)
• Similarity: 212/672 - (31%)
• Gaps: 302/672 - (44%)

  Fly   750 SASDLQPNP-----QQDSVREDQAIGATCTCAGTVRNIMTRPLSPQTTSEEFKIYLASIQMLQSA 809
            |..|.:..|     ..||..||.....|...:.......::....:..||:.|:.|.:.
Human     3 SPRDFRAEPVNDYEGNDSEAEDLNFRETLPSSSQENTPRSKVFENKVNSEKVKLSLRNF------ 61

  Fly   810 SNPLNQFDLIRLNYVFDHSYQTNRNIIEQPPVLGSN----------ARDVETPTD--MVPPSSED 862
              |.|.::                ::.|:|...||:          .||..:..|  ...||...
Human    62 --PHNDYE----------------DVFEEPSESGSDPSMWTARGPFRRDRWSSEDEEAAGPSQAL 108

  Fly   863 SELLASYQTVVS-----RMAQPIPE-------------LKENEQKRIFRDLHKEFWDLPLNHQEK 909
            |.||:..:.:||     ::||..|.             ||..|:|....|:.:||..|.|.:...
Human   109 SPLLSDTRKIVSEGELDQLAQIRPLIFNFHEQTAIKDCLKILEEKTAAYDIMQEFMALELKNLPG 173

  Fly   910 PMVFGSQ----TKNRYKTILPNENSRVLLESESSELTSLLGEIKRTSSVTASEDLPYINANYIK- 969
            ....|:|    .||||:.|||.:::||           .||:.|           .||||:||:
Human   174 EFNSGNQPSNREKNRYRDILPYDSTRV-----------PLGKSK-----------DYINASYIRI 216

  Fly   970 ---GPDYVSKCYVATQGPLPNTIFEFWLMIYQNTQRYIRRCVDGGSSSSPHVDREQILQQYFQKI 1031
               |.:|.   |:||||||.:||.:||.|:.:|....                           |
Human   217 VNCGEEYF---YIATQGPLLSTIDDFWQMVLENNSNV---------------------------I 251

  Fly  1032 VMLTNFTEANRQKCAVYFPIELNEIFAVAAKCEVFQLSAAARDYFDRYLTPTFVPDTVVASSDAI 1096
            .|:|...|....||..|:||.|.
Human   252 AMITREIEGGIIKCYHYWPISLK------------------------------------------ 274

  Fly  1097 DYEISGRHIGVESVKVTLEG-DLLEALPAQGSFFLIKNVGIVRRN---GYSVRKLVLLYCIRVPQ 1157
                  :.:.::..:|.||. .:|:       :|:|:...:|.::   .:||::|
Human   275 ------KPLELKHFRVFLENYQILQ-------YFIIRMFQVVEKSTGTSHSVKQL---------- 316

  Fly  1158 SASYHLQKIYCYHYWYPDWPDHHSPRDINTLLDTCLHVLNLGKCESEFDIYDDTRSERNAHLAAQ 1222
                          .:..||||.:|...::.:..                   .|..|.:||..
Human   317 --------------QFTKWPDHGTPASADSFIKY-------------------IRYARKSHLTG- 347

  Fly  1223 RLEIYQQDIFNAVQPLPVIHCSAGIGRTGCFTAILNAVRQLRQSLAYSLTGMLTKSLTSSSTEEY 1287
                          |: |:||||||||||.|..:
Human   348 --------------PM-VVHCSAGIGRTGVFLCV------------------------------- 366

  Fly  1288 HNPTDSDSSFTCNTIRHISHILDHRDAEAVKTPPSFDRLPKMPDIFVDVLGIVCNLRLQRGGMVQ 1352
                  |..| |..:::.|                           .:::.||..:|.||.||||
Human   367 ------DVVF-CAIVKNCS---------------------------FNIMDIVAQMREQRSGMVQ 397

  Fly  1353 NSEQYELIHRAICLYLKRTLAL 1374
            ..|||...:..:...|::.|.|
Human   398 TKEQYHFCYDIVLEVLRKLLTL 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	Y_phosphatase	916..1364	CDD:278528	92/459 (20%)
		PTPc	917..1364	CDD:238006	91/454 (20%)
PTPN20	NP_001035816.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..47		8/43 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	68..108		9/39 (23%)
		PTPc	159..411	CDD:214550	97/482 (20%)
		PTPc	185..411	CDD:238006	91/456 (20%)
		Substrate binding. /evidence=ECO:0000250	353..359		5/5 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900