DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTP-ER and Ptprz1

DIOPT Version :9

Sequence 1:	NP_726092.1	Gene:	PTP-ER / 37461	FlyBaseID:	FBgn0016641	Length:	1377	Species:	Drosophila melanogaster
Sequence 2:	NP_037212.2	Gene:	Ptprz1 / 25613	RGDID:	3455	Length:	2316	Species:	Rattus norvegicus

Alignment Length:	1657	Identity:	313/1657 - (18%)
Similarity:	519/1657 - (31%)	Gaps:	704/1657 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 YPYPQTPRPTHAAPSDTTPLEAGEDAESNKSTPYFTPLEYLQTSFEFPSPTVE--VGGGVPGFPE 78
            :.||         |::.||         :..||...||:...||....|.|.:  ..|..|..|.
  Rat   724 FAYP---------PTEVTP---------HAFTPSSRPLDLAPTSNILHSQTTQPVYNGETPLQPS 770

  Fly    79 HEDQEEEVFTP----RQFTITSPHPAAHVHHPSSSQS--------PTLGRKFKR-LSQYDRRSCS 130
            :..:...:.||    .|...|:  |||     |||.|        |::|..|.. ||.||.....
  Rat   771 YSSEVFPLVTPLLLDNQTLNTT--PAA-----SSSDSALHATPVFPSVGVSFDSILSSYDDAPLL 828

  Fly   131 P------------HINTSSGEERVSGRGIDKENTMPK-------------------GGSVDQDLE 164
            |            |::|.|             .|:|:                   ||  |..||
  Rat   829 PFSSASFSSDLFHHLHTVS-------------QTLPQVTSAAERDELSLHASLLVAGG--DLLLE 878

  Fly   165 NSL--YLSKSEHN------SPTILFKDESSTTPGLEASRLSYSPKLLSSINNLNVSGSPLNIINS 221
            .||  |.....|.      |.|:.|..||:         :.|...::|.|.      ||.:.:..
  Rat   879 PSLVQYSDVMSHQVTIHAASDTLEFGSESA---------VLYKTSMVSQIE------SPSSDVVM 928

  Fly   222 AGYKNGNFFRFPEIDHVVQDA-----------------------------------PMDTVCLEE 251
            ..|.:|     ||..:.::.:                                   |..:.....
  Rat   929 HAYSSG-----PETSYAIEGSHHVLTVSSSSAIPVHDSIGVADQGSLLINPSHISLPESSFITPT 988

  Fly   252 ATRRDRSPALAEPPEQQQQKSEGRKNRKNKNNLTIRITDVPIKNSSQPSPLPKPK-TPTIKSTKE 315
            |:.....|||:...|.....|:        :.|.:..|| .::..:..||:.... |.|...:.:
  Rat   989 ASLLQLPPALSGDGEWSGASSD--------SELLLPDTD-GLRTLNMSSPVSVADFTYTTSVSGD 1044

  Fly   316 KARSLDSA----ANESELSIVVHNITESHGSCDDMETGQSQPSTSVIHHHLHLQQPASAIHSTSL 376
            ..:.|...    .||:||.:         .|..||    :.||.|.:     :.:.:..::..|.
  Rat  1045 DIKPLSKGEMMYGNETELKM---------SSFSDM----AYPSKSTV-----VPKMSDIVNKWSE 1091

  Fly   377 SRLDSHLSLANQRRTPRRKSPGINT--TDWLMY--------HRKQNP---YQVQPTHCSSTTQSS 428
            |..::.:|:::           ||:  |:.|:|        ...:.|   :.|:|||.:|  |:|
  Rat  1092 SLKETSVSVSS-----------INSVFTESLVYPITKVFDQEISRVPEIIFPVKPTHTAS--QAS 1143

  Fly   429 LDSDASLTPSLGDFELKSACSVDGGSKFGIGASLAPRSAHKHNQ-LLHSSSTNLKTLPECLTLVE 492
                       ||..||...|.:  |:..:..:.:....|...| ||:.:::...|  |.|....
  Rat  1144 -----------GDTWLKPGLSTN--SEPALSDTASSEVLHPSTQPLLYEAASPFNT--EALLQPS 1193

  Fly   493 FSSSG----------GGPK-----ESPFKQK---SMDLPMPTLQA--KTTVSTSSMNLLQRRGSN 537
            |.:|.          .||:     |:|..::   ||.||:.:..|  |:|:..:|:.:|....|
  Rat  1194 FPASDVDTLLKTALPSGPRDPVLTETPMVEQSSSSMSLPLASESASSKSTLHFTSVPVLNMSPS- 1257

  Fly   538 HSLTLNLHSSCGNLMNSGLSHSNYSLGSILNSKS----------------SCNLDAGT------- 579
                 ::|.:....:....|...|....:|.|||                :.:||...
  Rat  1258 -----DVHPTSLQRLTVPHSREEYFEQGLLKSKSPQQVLPSLHSHDEFFQTAHLDISQAYPPKGR 1317

  Fly   580 ---ASQIRADQLPQSHLLGSSQGSRQGLFRRR---------------------GSNHSITLKTGH 620
               |:.|.:...||:.|:.....| :.:|...                     .::||:.|.:|.
  Rat  1318 HAFATPILSIDEPQNTLISRLVYS-EDIFMHPEISITDKALTGLPTTVSDVLIATDHSVPLGSGP 1381

  Fly   621 --------------TTT------------------------------------------------ 623
                          |||
  Rat  1382 ISMTTVSPNRDDSVTTTKLLLPSKATSKPTHSARSDADLVGGGEDGDDYDDDDYDDIDSDRFPVN 1446

  Fly   624 ---SCGDLNSMQQ-------LQQQQAMLSAEKYNRLNMRTNSTGSGSGSG------SNVPTPKRG 672
               ||......|:       .|:...:..::..:.| :..|:.....|:|      |...:|...
  Rat  1447 KCMSCSPYRESQEKVMNDSDTQESSLVDQSDPISHL-LSENTEEENGGTGVTRVDKSPDKSPPPS 1510

  Fly   673 LLERRGSNQSLTLNMGSILGGAAGTEIQMTDIVQPK---------VTVCSCAAANQAPHQRKFFS 728
            :|.::.::            |....:|||...|.|.         :|....:.:.|.       :
  Rat  1511 MLPQKHND------------GREDRDIQMGSAVLPHTPGSKAWAVLTSDEESGSGQG-------T 1556

  Fly   729 TENLNSSKANSQKFFGQVCFGSASDL-----------QPNPQQDSVREDQAIGATCTCAGTVRNI 782
            :::||.::.::...|..|....|..:           .|.....||....: |.:.:......|
  Rat  1557 SDSLNDNETSTDFSFPDVNEKDADGVLEADDTGIAPGSPRSSTPSVTSGHS-GVSNSSEAEASN- 1619

  Fly   783 MTRPLSPQTTSEEFKIYLA-SIQMLQSASNPLNQFD---------LIRLNYVFDHSYQTNRNIIE 837
                     :|.|.:|.|| .::..:.|..||....         |:.:...:...:||....:|
  Rat  1620 ---------SSHESRIGLAEGLESEKKAVIPLVIVSALTFICLVVLVGILIYWRKCFQTAHFYLE 1675

  Fly   838 QPPVLGSNARDVETPTDMVPPSSEDSELLASYQTVVSRMAQPIPELKENEQKRIFRDLH------ 896
            .    .::.|.:.||...:.|.|:|..            |.||....::     ..|||
  Rat  1676 D----NTSPRVISTPPTPIFPISDDIG------------AIPIKHFPKH-----VADLHASNGFT 1719

  Fly   897 ------KEFW--------DLPL-----NHQEKPMVFGSQTKNRYKTILPNENSRVLLESESSELT 942
                  |||:        ||.:     ||.:      ::.||||..|:..::|||       :||
  Rat  1720 EEFETLKEFYQEVQSCTVDLGITADSSNHPD------NKHKNRYVNIVAYDHSRV-------KLT 1771

  Fly   943 SLLGEIKRTSSVTASED---LPYINANYIKGPDYVSKCYVATQGPLPNTIFEFWLMIYQNTQRYI 1004
            .|           |.:|   ..||||||:.|.:. .|.|:|.||||.:|..:||.||:::.
  Rat  1772 QL-----------AEKDGKLTDYINANYVDGYNR-PKAYIAAQGPLKSTAEDFWRMIWEHN---- 1820

  Fly  1005 RRCVDGGSSSSPHVDREQILQQYFQKIVMLTNFTEANRQKCAVYFPIELNEIFAVAAKCEVFQLS 1069
                                   .:.|||:||..|..|:||..|:|.:.:|.:   ....|.|.:
  Rat  1821 -----------------------VEVIVMITNLVEKGRRKCDQYWPTDGSEEY---GSFLVNQKN 1859

  Fly  1070 AAARDYFDRYLTPTFVPDTVVASSDAIDYEISGRHIGVESVKVTLEGDLLEALPAQGSFFLIKNV 1134
            .....|:           ||             |:..:.:.|:           .:||
  Rat  1860 VQVLAYY-----------TV-------------RNFTLRNTKI-----------KKGS------- 1882

  Fly  1135 GIVRRNGYSVRKLVLLYCIRVPQSASYHLQKIYCYHYWYPDWPDHHSPRDINTLLDTCLHVLNLG 1199
                :.|.|..:||          ..||          |..|||...|       :..|.||...
  Rat  1883 ----QKGRSSGRLV----------TQYH----------YTQWPDMGVP-------EYSLPVLAFV 1916

  Fly  1200 KCESEFDIYDDTRSERNAHLAAQRLEIYQQDIFNAVQPLPVIHCSAGIGRTGCFTAILNAVRQLR 1264
            :..::                |:|         :||.|: |:|||||:||||.:..:.:.::|::
  Rat  1917 RKTAQ----------------AKR---------HAVGPV-VVHCSAGVGRTGTYIVLDSMLQQIQ 1955

  Fly  1265 QSLAYSLTGMLTKSLTSSSTEEYHNPTDSDSSFTCNTIRHISHILDHRDAEAVKTPPSFDRLPKM 1329
                                   |..|
  Rat  1956 -----------------------HEGT-------------------------------------- 1959

  Fly  1330 PDIFVDVLGIVCNLRLQRGGMVQNSEQYELIH 1361
                |::.|.:.::|.||..:||..|||..||
  Rat  1960 ----VNIFGFLKHIRSQRNYLVQTEEQYVFIH 1987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	Y_phosphatase	916..1364	CDD:278528	97/449 (22%)
PTP-ER	NP_726092.1	PTPc	917..1364	CDD:238006	97/448 (22%)
Ptprz1	NP_037212.2	alpha_CARP_receptor_like	45..298	CDD:239396
		fn3	313..401	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	433..499
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	518..537
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	586..624
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	636..720
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1141..1172		9/43 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1204..1228		4/23 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1401..1521		12/132 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1545..1622		12/94 (13%)
		PTPc	1717..1992	CDD:214550	104/490 (21%)
		PTPc	1753..1992	CDD:238006	97/448 (22%)
		Substrate binding. /evidence=ECO:0000250	1934..1940		4/5 (80%)
		PTPc	2023..2281	CDD:214550
		PTPc	2051..2281	CDD:238006
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900