DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTP-ER and pyp2

DIOPT Version :9

Sequence 1:	NP_726092.1	Gene:	PTP-ER / 37461	FlyBaseID:	FBgn0016641	Length:	1377	Species:	Drosophila melanogaster
Sequence 2:	NP_594899.1	Gene:	pyp2 / 2542200	PomBaseID:	SPAC19D5.01	Length:	711	Species:	Schizosaccharomyces pombe

Alignment Length:	719	Identity:	142/719 - (19%)
Similarity:	219/719 - (30%)	Gaps:	331/719 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly   705 VQPKVTVCSCAAANQAPHQRKFFSTENLNSSKANSQKFFGQVCFGSASDLQPNPQQDSVREDQAI 769
            :.|.:: |:.:..:....|:.||...|..                     |..|.:.|:|...:.
pombe   249 ISPAIS-CASSCPSTPDEQKNFFIVGNAP---------------------QQTPARPSLRSVPSY 291

  Fly   770 GATCTCAGTVRNIMTRPLSPQTTSEEFKIYLASIQMLQSASNP-LNQFDL---IRLNYVFDHSYQ 830
            .::        |...||.:.:..|  |..|:.|..::    || |:|..|   .|.:...|.:.|
pombe   292 PSS--------NNQRRPSASRVRS--FSNYVKSSNVV----NPSLSQASLEIIPRKSMKRDSNAQ 342

  Fly   831 ---TNRNIIEQPPVLG-SNARDVETP-----------------------------------TDMV 856
               |:....:..|.:| ||.||...|                                   ..:.
pombe   343 NDGTSTMTSKLKPSVGLSNTRDAPKPGGLRRANKPCFNKETKGSIFSKENKGPFTCNPWGAKKVS 407

  Fly   857 PPSSEDSELLASYQTVVSRMAQPIPELKENEQKR--IFRDLHKEFWDLPLNHQEKPMVFGSQTKN 919
            ||   ..|:||...|  :.:......|:|.|..|  .|.| .|..|....:.:...:    ..||
pombe   408 PP---PCEVLADLNT--ASIFYKFKRLEEMEMTRSLAFND-SKSDWCCLASSRSTSI----SRKN 462

  Fly   920 RYKTILPNENSRVLLESESSELTSLLGEIKRTSSVTASEDLPYINANYIKGPDYVSKCYVATQGP 984
            ||..|:|.:.:||.|            .:.:..|       .||||::|   |..:|.|:|.|.|
pombe   463 RYTDIVPYDKTRVRL------------AVPKGCS-------DYINASHI---DVGNKKYIACQAP 505

  Fly   985 LPNTIFEFWLMIYQNTQRYIRRCVDGGSSSSPHVDREQILQQYFQKIVMLTNFTEANRQKCAVYF 1049
            .|.|:.:||.|::.|:          |::.               .||||||..||..:||:.|:
pombe   506 KPGTLLDFWEMVWHNS----------GTNG---------------VIVMLTNLYEAGSEKCSQYW 545

  Fly  1050 PIELNEIFAVAAKCEVFQLSAAARDYFDRYLTPTFVPDTVVASSDAIDYEISGRHIGVESVKVTL 1114
            |                                           |..|:.:            .|
pombe   546 P-------------------------------------------DNKDHAL------------CL 555

  Fly  1115 EGDLLEALPAQGSFFLIKNVGIVRRNGYSVRKLVLLYCIRVPQSASYHLQKI--------YCYHY 1171
            ||.|                      ..||:|......::|    :.||.::        |.:|:
pombe   556 EGGL----------------------RISVQKYETFEDLKV----NTHLFRLDKPNGPPKYIHHF 594

  Fly  1172 WYPDWPDHHSPRDINTLLDTCLHVLNLGKCESEFDIYDDTRSERNAHLAAQRLEIYQQDIFNAVQ 1236
            |...|.|...| ||.::                                        ..|...:.
pombe   595 WVHTWFDKTHP-DIESI----------------------------------------TGIIRCID 618

  Fly  1237 PLP-----VIHCSAGIGRTGCFTAILNAVRQLRQSLAYSLTGMLTKSLTSSSTEEYHNPTDS-DS 1295
            .:|     .:|||||:||||.|.    ||.|:.|         :.|::...:|    |..|| |.
pombe   619 KVPNDGPMFVHCSAGVGRTGTFI----AVDQILQ---------VPKNILPKTT----NLEDSKDF 666

  Fly  1296 SFTCNTIRHISHILDHRDAEAVKTPPSFDRLPKMPDIFVDVLGIVCNLRLQRGGMVQNSEQYELI 1360
            .|.|                                        |.:||.||..||||.||::.:
pombe   667 IFNC----------------------------------------VNSLRSQRMKMVQNFEQFKFL 691

  Fly  1361 HRAI 1364
            :..:
pombe   692 YDVV 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	Y_phosphatase	916..1364	CDD:278528	95/461 (21%)
PTP-ER	NP_726092.1	PTPc	917..1364	CDD:238006	95/460 (21%)
pyp2	NP_594899.1	DSP_MapKP	4..129	CDD:238723
		COG5599	405..709	CDD:227886	109/527 (21%)
		PTPc	461..697	CDD:238006	95/461 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19134
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000