DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTP-ER and Ptprz1

DIOPT Version :9

Sequence 1:	NP_726092.1	Gene:	PTP-ER / 37461	FlyBaseID:	FBgn0016641	Length:	1377	Species:	Drosophila melanogaster
Sequence 2:	XP_006505075.1	Gene:	Ptprz1 / 19283	MGIID:	97816	Length:	2318	Species:	Mus musculus

Alignment Length:	1636	Identity:	321/1636 - (19%)
Similarity:	511/1636 - (31%)	Gaps:	670/1636 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 PYPQTP--RPTHAAP------SDTT-PLEAGEDAESNKSTPYFTPLEYLQTSFEFPSPTVEVGGG 72
            |...||  ||...||      |.|| |:..||           |||:...:|..||..|
Mouse   733 PQAFTPSSRPLDLAPTINILHSQTTQPVYNGE-----------TPLQPSYSSEVFPLAT------ 780

  Fly    73 VPGFPEHEDQEEEVFTPRQFTITSPHPAAHVHHPSSSQSPTLGRKFKR-LSQYDRRSCSPHINTS 136
                |...|.:....||   ..:|...|.|    ::..||::|..|:. ||.||.....|..:.|
Mouse   781 ----PLLLDNQTLNTTP---AASSSDSALH----ATPVSPSVGVSFESILSSYDDAPLLPFSSAS 834

  Fly   137 SGEE------RVSGRGIDKENTMPKGGSV-----------------DQDLENSL--YLSKSEHNS 176
            ...|      .||       .|:|:..|.                 |..||.||  |...:.|.:
Mouse   835 FSSEMFRHLHTVS-------QTLPQVTSAAERDELSLHASLLVARGDLLLEPSLVQYSDVASHQA 892

  Fly   177 PTILFKDESSTTPGL-EASRLSYSPKLLSSINNLNVSGSPLNIINSAGYKNGNFFRFPEIDHVVQ 240
            .|    ..:|.|.|. ..|.:.|...::|.|.      ||.:.:....|.:|     ||..:.|:
Mouse   893 TT----RAASDTLGFGSESAVFYKTSMVSQIE------SPRSDVVMHAYSSG-----PEPSYTVE 942

  Fly   241 DA-PMDTVCLEEATRRDRSPALAEPPEQQQQKSEGRKNRKNKNNLTIRITDVPIKNSS------- 297
            .: .:.||....|                 ....|..:..::.:|.|..:.:.:..||
Mouse   943 GSHHVPTVSYSSA-----------------MPLHGSVDVSDQGSLLINPSHISMPESSFITPTAS 990

  Fly   298 --QPSP------------------LPKP---KTPTIKS-----------------TKEKARSLDS 322
              ||.|                  ||..   :|..|.|                 .|..::|...
Mouse   991 LLQPPPALSGDGEWSGASSDSELLLPDADGLRTLNISSPVSVAEFTYTTSVFADGIKPLSKSEMM 1055

  Fly   323 AANESELSIVVHNITESHGSCDDMETGQSQPSTSVIHHHLHLQQPASAIHSTSLSRLDSHLSLAN 387
            ..||:||.:         .|..||    :.||.|.:     :.:.:..:|..|.|..::.:|:::
Mouse  1056 YGNETELKM---------SSFSDM----AYPSKSTV-----VPKMSDVVHKWSESLKETSVSISS 1102

  Fly   388 QRR---------TPRRKSPGINTTDWLMYHRKQNPYQVQPTHCSSTTQSSLDSDASLTPSLGDFE 443
            .:.         |.:....|::       |..:..:.|||||.:|  |:|           ||..
Mouse  1103 MKSVFPESLVYPTTKGFEQGVS-------HVPEIIFPVQPTHTAS--QAS-----------GDTW 1147

  Fly   444 LKSACSVDGGSKFGIGASLAPRSAHKHNQ-LLHSSSTNLKTLPECLTLVEFSSSGGGPKESPFKQ 507
            ||...|.:..:.|...||  ....|...| ||:.::|...|  |.|....|.:|   ..::..|.
Mouse  1148 LKPGLSANSEAAFSDTAS--REVVHPSTQPLLYEAATPFNT--EALLQPSFQAS---DVDTLLKT 1205

  Fly   508 KSMDLPMP-----TLQAKTTVSTSSMNLLQRRGSNHSLTLNLHSSCGNLMN-----------SGL 556
            ....:|..     |.|.:.:.|:.|..:....||:.|:   ||.:...:::           .||
Mouse  1206 ALPSVPSDPILAGTPQVEQSSSSVSHPMASESGSSESM---LHFTSVPILDISPSKVHSTPLQGL 1267

  Fly   557 S--HSN--YSLGSILNSKS----------------SCNLDAGTA----------SQIRADQLPQS 591
            :  ||:  :|...:|.|||                |.:||...|          :.:.:...||:
Mouse  1268 TVPHSSKKFSEQGLLKSKSPQQVLPSLFSNDEFFQSAHLDVSQAYPPKGRHAFVTPVLSIDEPQN 1332

  Fly   592 HLLGSSQGSRQGLFRR---------------------RGSNHSITLKTGHTTTSCGDLNSMQQLQ 635
            .|:.....| :.:|..                     ..::||:.|.:|..:.:....|....:.
Mouse  1333 TLINKLVYS-EDIFSSTEISITDKVLTGLPTLASDVLSSTDHSVPLGSGPISLTMVSPNRDDSVT 1396

  Fly   636 QQQAMLSAEKYNRLNMRTNSTGSGSGSG-------------------------SNVP-------- 667
            ..:.:|.:...::|.....|.....|.|                         |.:|
Mouse  1397 TAKLLLPSTATSKLTQSARSDADLVGGGEDGDDYDDDDYDDIDRGRFPVNKCMSCLPYRESREKV 1461

  Fly   668 -----TPKRGLLERRGSNQSLTLNMGSILGGAAG-----------------------TEIQMTDI 704
                 |.:..|:::......|.........|..|                       ::|||...
Mouse  1462 MNDSDTQESSLVDQSDPISPLLFENTEEENGGTGVTRVDKSPPPSMLPQNHNDGKEDSDIQMGSA 1526

  Fly   705 VQPK---------VTVCSCAAANQAPHQRKFFSTENLNSSKANSQKFFGQVCFGSASDLQPNPQQ 760
            |.|.         :|....:.:.|.       ::::||.::.::...|..|         .....
Mouse  1527 VLPHTPGSKAWAVLTSDEESGSGQG-------TSDSLNDNETSTDFSFPDV---------NEKDT 1575

  Fly   761 DSVREDQAIGATCTCAGTVRNIMTRPLSPQT----------------------TSEEFKIYLA-S 802
            |.|.|....|..             |.||::                      :|.|.:|.|| .
Mouse  1576 DGVLETDDTGIA-------------PGSPRSSTPSVTSGHSGVSNSSEAEASNSSHESRIGLAEG 1627

  Fly   803 IQMLQSASNPLNQFD---------LIRLNYVFDHSYQTNRNIIEQPPVLGSNARDVETPTDMVPP 858
            ::..:.|..||....         |:.:...:...:||....:|.    .::.|.:.||...:.|
Mouse  1628 LESEKKAVIPLVIVSALTFICLVVLVGILIYWRKCFQTAHFYLED----NTSPRVISTPPTPIFP 1688

  Fly   859 SSEDSELLASYQTVVSRMAQPIPELKENEQKRIFRDLH------------KEFW--------DLP 903
            .|:|..            |.||....::     ..|||            |||:        ||.
Mouse  1689 ISDDIG------------AIPIKHFPKH-----VADLHASNGFTEEFETLKEFYQEVQSCTADLG 1736

  Fly   904 L-----NHQEKPMVFGSQTKNRYKTILPNENSRVLLESESSELTSLLGEIKRTSSVTASED---L 960
            :     ||.:      ::.||||..|:..::|||       :||.|           |.:|   .
Mouse  1737 ITADSSNHPD------NKHKNRYVNIVAYDHSRV-------KLTQL-----------AEKDGKLT 1777

  Fly   961 PYINANYIKGPDYVSKCYVATQGPLPNTIFEFWLMIYQNTQRYIRRCVDGGSSSSPHVDREQILQ 1025
            .||||||:.|.:. .|.|:|.||||.:|..:||.||:::.
Mouse  1778 DYINANYVDGYNR-PKAYIAAQGPLKSTAEDFWRMIWEHN------------------------- 1816

  Fly  1026 QYFQKIVMLTNFTEANRQKCAVYFPIELNEIFAVAAKCEVFQLSAAARDYFDRYLTPTFVPDTVV 1090
              .:.|||:||..|..|:||..|:|.:.:|.:   ....|.|.|.....|:           ||
Mouse  1817 --VEVIVMITNLVEKGRRKCDQYWPTDGSEEY---GSFLVNQKSVQVLAYY-----------TV- 1864

  Fly  1091 ASSDAIDYEISGRHIGVESVKVTLEGDLLEALPAQGSFFLIKNVGIVRRNGYSVRKLVLLYCIRV 1155
                        |:..:.:.|:....:|.     |||           :.|.|..:||
Mouse  1865 ------------RNFTLRNTKLKKLSELF-----QGS-----------QKGRSSGRLV------- 1894

  Fly  1156 PQSASYHLQKIYCYHYWYPDWPDHHSPRDINTLLDTCLHVLNLGKCESEFDIYDDTRSERNAHLA 1220
               ..||          |..|||                   :|..|....:....|.      |
Mouse  1895 ---TQYH----------YTQWPD-------------------MGVPEYSLPVLAFVRK------A 1921

  Fly  1221 AQRLEIYQQDIFNAVQPLPVIHCSAGIGRTGCFTAILNAVRQLRQSLAYSLTGMLTKSLTSSSTE 1285
            ||...       :||.|: |:|||||:||||.:..:.:.::|::
Mouse  1922 AQAKR-------HAVGPV-VVHCSAGVGRTGTYIVLDSMLQQIQ--------------------- 1957

  Fly  1286 EYHNPTDSDSSFTCNTIRHISHILDHRDAEAVKTPPSFDRLPKMPDIFVDVLGIVCNLRLQRGGM 1350
              |..|                                          |::.|.:.::|.||..:
Mouse  1958 --HEGT------------------------------------------VNIFGFLKHIRSQRNYL 1978

  Fly  1351 VQNSEQYELIH 1361
            ||..|||..||
Mouse  1979 VQTEEQYVFIH 1989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	Y_phosphatase	916..1364	CDD:278528	100/449 (22%)
PTP-ER	NP_726092.1	PTPc	917..1364	CDD:238006	100/448 (22%)
Ptprz1	XP_006505075.1	alpha_CARP_receptor_like	45..298	CDD:239396
		fn3	313..395	CDD:365830
		PTP_DSP_cys	1714..1997	CDD:391942	107/489 (22%)
		R-PTP-Z-2	2080..2283	CDD:350507
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900