DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTP-ER and Ptprr

DIOPT Version :9

Sequence 1:	NP_726092.1	Gene:	PTP-ER / 37461	FlyBaseID:	FBgn0016641	Length:	1377	Species:	Drosophila melanogaster
Sequence 2:	NP_035347.1	Gene:	Ptprr / 19279	MGIID:	109559	Length:	656	Species:	Mus musculus

Alignment Length:	998	Identity:	211/998 - (21%)
Similarity:	299/998 - (29%)	Gaps:	519/998 - (52%)

- Green bases have known domain annotations that are detailed below.

  Fly   469 KHNQLLHSS--------STNLKTLPECLTLVEFSSSGGGPKESPFKQKSMDLPMP-------TLQ 518
            ||:|:::|:        |.||..                  ||....:..:||:|       |||
Mouse    75 KHHQIINSAFPRPAYDPSLNLLA------------------ESDQDLEIENLPIPAANVIVVTLQ 121

  Fly   519 AKTTVSTSSMNLLQRRGSNHSLTLNLHSSCGNLMNSGLSHSNYSLGSILNSK-------SSCNLD 576
            ...|....::..:.|:|...:|              ||......:..::..|       |..|..
Mouse   122 MDITKLNITLLRIFRQGVAAAL--------------GLLPQQVHINRLIEKKNQVELFVSPGNRK 172

  Fly   577 AGTASQIRADQL----------------------PQSHLLGSSQG--------SRQGLFR----- 606
            .|....::|:::                      |:.::|   ||        |::|.:.
Mouse   173 PGETQALQAEEVLRSLNVDGLHQSLPQFGITDVAPEKNVL---QGQHEADKIWSKEGFYAVVIFL 234

  Fly   607 --------------RRGSNHSITLKTGHTTTSCGDLNSMQQLQ-----QQQAMLSAEKYNR---- 648
                          |......::|:.        |....|::.     :|||...|:..:.
Mouse   235 SIFIIIVTCLMIIYRLKERLQLSLRQ--------DKEKNQEIHLSPIARQQAQSEAKTTHSMVQP 291

  Fly   649 ------LNMRTNSTGS------GSGSGSNVPTPKR----GLLERRGSNQSLTLNMGSILGGAAGT 697
                  ||:..:..|.      .|.|.|..|:|.|    ||.||||||.||||:|.| ||.
Mouse   292 DQAPKVLNVVVDPQGQCTPEIRNSTSTSVCPSPFRMKPIGLQERRGSNVSLTLDMSS-LGS---- 351

  Fly   698 EIQMTDIVQPKVTVCSCAAANQAPHQRKFFSTENLNSSKANSQKFFGQVCFGSASDLQPNPQQDS 762
                   |:|.|.|       ..|.::
Mouse   352 -------VEPFVAV-------STPREK-------------------------------------- 364

  Fly   763 VREDQAIGATCTCAGTVRNIMTRPLSPQTTSEEFKIYLASIQMLQSASNPLNQFDLIRLNYVFDH 827
                                                  .:::.|||||..|.:..|
Mouse   365 --------------------------------------VAMEYLQSASRVLTRSQL--------- 382

  Fly   828 SYQTNRNIIEQPPVLGSNARDVETPTDMVPPSSEDSELLASYQTVVSRMAQPIPELKENEQKRIF 892
                 |:::....:|.|..  :|.|.:.|.|
Mouse   383 -----RDVVASSHLLQSEF--MEIPMNFVDP---------------------------------- 406

  Fly   893 RDLHKEFWDLPLNHQEKPMVFGSQTKNRYKTILPNENSRVLLESESSELTSLLGEIKRTSSVTAS 957
                ||. |:|.:          .|||||||||||..|||.|               |..::|.|
Mouse   407 ----KEI-DIPRH----------GTKNRYKTILPNPLSRVCL---------------RPKNITDS 441

  Fly   958 EDLPYINANYIKGPDYVSKCYVATQGPLPNTIFEFWLMIYQNTQRYIRRCVDGGSSSSPHVDREQ 1022
            .. .|||||||:|.....|.::|||||:.||:.:||.|::|              ..||
Mouse   442 LS-TYINANYIRGYSGKEKAFIATQGPMINTVNDFWQMVWQ--------------EDSP------ 485

  Fly  1023 ILQQYFQKIVMLTNFTEANRQKCAVYFPIELNEIFAVAAKCEVFQLSAAARDYFDRYLTPTFVPD 1087
                   .|||:|...|.| :||.:|:|    |...:..|.||.
Mouse   486 -------VIVMITKLKEKN-EKCVLYWP----EKRGIYGKVEVL--------------------- 517

  Fly  1088 TVVASSDAIDYEISGRHIGVESVKVTLEGDLLEALPAQGSFFLIKNVGIVRRNGYSVRKLVLLYC 1152
                                    ||                     |:...:.|::|.|||
Mouse   518 ------------------------VT---------------------GVTECDNYTIRNLVL--- 534

  Fly  1153 IRVPQSASYHLQKIYCYHYWYPDWPDHHSPRDINTLLDTCLHVLNLGKCESEFDIYDDTRSERNA 1217
                 ....|.|.:  .||||..||||.:|.....||...|            |:.:|
Mouse   535 -----KQGSHTQHV--KHYWYTSWPDHKTPDSAQPLLQLML------------DVEED------- 573

  Fly  1218 HLAAQRLEIYQQDIFNAVQPLPVIHCSAGIGRTGCFTAILNAVRQLRQSLAYSLTGMLTKSLTSS 1282
            .||::           ...|: |:||||||||||||.|.....:||::
Mouse   574 RLASE-----------GRGPV-VVHCSAGIGRTGCFIATSIGCQQLKE----------------- 609

  Fly  1283 STEEYHNPTDSDSSFTCNTIRHISHILDHRDAEAVKTPPSFDRLPKMPDIFVDVLGIVCNLRLQR 1347
                                            |.|                ||.|.|||.||:.|
Mouse   610 --------------------------------EGV----------------VDALSIVCQLRVDR 626

  Fly  1348 GGMVQNSEQYELIHRAICLYLKR 1370
            |||||.|||||.:|.|:||:..|
Mouse   627 GGMVQTSEQYEFVHHALCLFESR 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	Y_phosphatase	916..1364	CDD:278528	119/447 (27%)
PTP-ER	NP_726092.1	PTPc	917..1364	CDD:238006	119/446 (27%)
Ptprr	NP_035347.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	269..289		4/19 (21%)
		PTPc	391..643	CDD:214550	129/522 (25%)
		PTPc	416..643	CDD:238006	119/446 (27%)
		Substrate binding. /evidence=ECO:0000250	587..593		5/5 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3560
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.910