Protein Alignment PTP-ER and Ptpn22

DIOPT Version :9

• Sequence 1: NP_726092.1
• Gene: PTP-ER / 37461
• FlyBaseID: FBgn0016641
• Length: 1377
• Species: Drosophila melanogaster
• Sequence 2: NP_033005.1
• Gene: Ptpn22 / 19260
• MGIID: 107170
• Length: 802
• Species: Mus musculus
• Alignment Length: 515
• Identity: 111/515 - (21%)
• Similarity: 158/515 - (30%)
• Gaps: 255/515 - (49%)

  Fly   887 EQKRIFRDLHKEFWDLPLNHQEKPMVFGSQ----------------------------TKNRYKT 923
            :|:.|.:.|.||.....||.:|    |.|:                            .|||||.
Mouse     2 DQREILQQLLKEAQKKKLNSEE----FASEFLKLKRQSTKYKADKIYPTTVAQRPKNIKKNRYKD 62

  Fly   924 ILPNENSRVLLESESSELTSLLGEIKRTSSVTASEDLPYINANYIKGPDYVSKCYVATQGPLPNT 988
            |||.::|.|.|                 |.:|:.||..||||::|||. |..|.|:||||||..|
Mouse    63 ILPYDHSLVEL-----------------SLLTSDEDSSYINASFIKGV-YGPKAYIATQGPLSTT 109

  Fly   989 IFEFWLMIYQNTQRYIRRCVDGGSSSSPHVDREQILQQYFQKIVMLTNFTEANRQKCAVYF--PI 1051
            :.:||.||::                      .:||     .|||.....|..::||..|:  |.
Mouse   110 LLDFWRMIWE----------------------YRIL-----VIVMACMEFEMGKKKCERYWAEPG 147

  Fly  1052 ELNEIFAVAAKCEVFQLSAAARDYFDRYLTPTFVPDTVVASSDAIDYEISGRHIGVESVKVTLEG 1116
            |....|.      .|.:|..|..
Mouse   148 ETQLQFG------PFSISCEAEK------------------------------------------ 164

  Fly  1117 DLLEALPAQGSFFLIKNVGIVRRNGYSVRKLVLLYCIRVPQSASYHLQKIYCYHYWYPDWPDHHS 1181
                                 :::.|.:|.|          .|.::.:....|.:.|.:||||..
Mouse   165 ---------------------KKSDYKIRTL----------KAKFNNETRIIYQFHYKNWPDHDV 198

  Fly  1182 PRDINTLLDTCLHVLNLGKCESEFDIYDDTRSERNAHLAAQRLEIYQQDIFNAVQPLPV-IHCSA 1245
            |..|:.:|..               |:|              :..||:|     ..:|: |||||
Mouse   199 PSSIDPILQL---------------IWD--------------MRCYQED-----DCVPICIHCSA 229

  Fly  1246 GIGRTGCFTAILNAVRQLRQSLAYSLTGMLTKSLTSSSTEEYHNPTDSDSSFTCNTIRHISHILD 1310
            |.||||...|:             ..|.||.|.
Mouse   230 GCGRTGVICAV-------------DYTWMLLKD-------------------------------- 249

  Fly  1311 HRDAEAVKTPPSFDRLPKMPDIFVDVLGIVCNLRLQRGGMVQNSEQYELIHRAICLYLKR 1370
                         ..:||...:|    .::..:|.||..:||..|||||::.|:....||
Mouse   250 -------------GIIPKNFSVF----NLIQEMRTQRPSLVQTQEQYELVYSAVLELFKR 292

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	Y_phosphatase	916..1364	CDD:278528	98/478 (21%)
		PTPc	917..1364	CDD:238006	98/449 (22%)
Ptpn22	NP_033005.1	PTPc-N22	57..290	CDD:350450	99/452 (22%)
		Substrate binding. /evidence=ECO:0000250	227..233		4/5 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	330..358
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	536..564
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	597..619
		Interaction with CSK. /evidence=ECO:0000269|PubMed:8890164	613..621
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	653..695
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	713..802

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900