Protein Alignment PTP-ER and Ptpn2

DIOPT Version :9

• Sequence 1: NP_726092.1
• Gene: PTP-ER / 37461
• FlyBaseID: FBgn0016641
• Length: 1377
• Species: Drosophila melanogaster
• Sequence 2: NP_001120649.1
• Gene: Ptpn2 / 19255
• MGIID: 97806
• Length: 406
• Species: Mus musculus
• Alignment Length: 474
• Identity: 88/474 - (18%)
• Similarity: 139/474 - (29%)
• Gaps: 222/474 - (46%)

  Fly   891 IFRDLHKEFWDLPLNHQEKPMVFGSQTKNRYKTILPNENSRVLLESESSELTSLLGEIKRTSSVT 955
            ::.::..|..|.|....:.|   .::.:|||:.:.|.::|||.|:|..::
Mouse    21 LYLEIRNESHDYPHRVAKFP---ENRNRNRYRDVSPYDHSRVKLQSTEND--------------- 67

  Fly   956 ASEDLPYINANYIKGPDYVSKCYVATQGPLPNTIFEFWLMIYQNTQRYIRRCVDGGSSSSPHVDR 1020
                  ||||:.: ..:...:.|:.||||||||...||||::
Mouse    68 ------YINASLV-DIEEAQRSYILTQGPLPNTCCHFWLMVW----------------------- 102

  Fly  1021 EQILQQYFQKIVMLTNFTEANRQKCAVYFPIELNEIFAVAAKCEVFQLSAAARDYFDRYLTPTFV 1085
                ||..:.:|||....|....|||.|:|.:..|:........|..||...:.|:..:|
Mouse   103 ----QQKTKAVVMLNRTVEKESVKCAQYWPTDDREMVFKETGFSVKLLSEDVKSYYTVHL----- 158

  Fly  1086 PDTVVASSDAIDYEISGRHIGVESVKVTLEGDLLEALPAQGSFFLIKNVGIVRRNGYSVRKLVLL 1150
                               :.:|::                      |.|..|.
Mouse   159 -------------------LQLENI----------------------NTGETRT----------- 171

  Fly  1151 YCIRVPQSASYHLQKIYCYHYWYPDWPDHHSPRDINTLLDTCLHVLNLGKCESEFDIYDDTRSER 1215
                             ..|:.|..|||...|....:.|:....|...|....:
Mouse   172 -----------------ISHFHYTTWPDFGVPESPASFLNFLFKVRESGCLTPD----------- 208

  Fly  1216 NAHLAAQRLEIYQQDIFNAVQPLPVIHCSAGIGRTGCFTAILNAVRQLRQSLAYSLTGMLTKSLT 1280
              |..|                  ||||||||||:|.|:.:
Mouse   209 --HGPA------------------VIHCSAGIGRSGTFSLV------------------------ 229

  Fly  1281 SSSTEEYHNPTDSDSSFTCNTIRHISHILDHRDAEAVKTPPSFDRLPKMPDIFVDVLGIVCNLRL 1345
                            .||..:                       :.|..|  |:|..::.|:|.
Mouse   230 ----------------DTCLVL-----------------------MEKGED--VNVKQLLLNMRK 253

  Fly  1346 QRGGMVQNSEQYELIHRAI 1364
            .|.|::|..:|....:.||
Mouse   254 YRMGLIQTPDQLRFSYMAI 272

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	Y_phosphatase	916..1364	CDD:278528	82/447 (18%)
		PTPc	917..1364	CDD:238006	82/446 (18%)
Ptpn2	NP_001120649.1	PTPc	5..274	CDD:214550	88/474 (19%)
		PTPc	45..274	CDD:238006	84/447 (19%)
		Substrate binding. /evidence=ECO:0000250	216..222		5/5 (100%)
		Endoplasmic reticulum location. /evidence=ECO:0000250	341..406
		Mediates interaction with STX17. /evidence=ECO:0000250	371..406

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900