Protein Alignment PTP-ER and ZK354.8

DIOPT Version :10

• Sequence 1: NP_726092.1
• Gene: PTP-ER / 37461
• FlyBaseID: FBgn0016641
• Length: 1377
• Species: Drosophila melanogaster
• Sequence 2: NP_500775.1
• Gene: ZK354.8 / 191295
• WormBaseID: WBGene00022709
• Length: 483
• Species: Caenorhabditis elegans
• Alignment Length: 588
• Identity: 116/588 - (19%)
• Similarity: 173/588 - (29%)
• Gaps: 298/588 - (50%)

  Fly   838 QPPVLGSNARDVETPTDMVPPSSEDSELLASYQTVVSRMAQPI--------------PELKENEQ 888
            ||||:.|....: :|...:|||                ||||:              |..::.::
 Worm   121 QPPVINSQLPRM-SPAPAIPPS----------------MAQPLLQSPSPGADIAIRRPSKEKTDE 168

  Fly   889 KRI--------------------------FRDLHKEFWDLPLNHQEKP-----MVFGSQTKNRYK 922
            |.:                          ...|.||:.|.|   .|.|     ...|:.|:|||:
 Worm   169 KSVDETGGSDKKKRTEVICSWIRLVLQNGVAGLKKEYRDSP---NEAPEDIATSFLGNPTRNRYR 230

  Fly   923 TILPNENSRVLLESESSELTSLLGEIKRTSSVTASEDLP--YINANYI-KGPDYVSKCYVATQGP 984
            .|...:.:||.|                       .|.|  ||:||.: .||:  .:.::.||.|
 Worm   231 NIPCCDITRVKL-----------------------TDDPHFYIHANLVSSGPN--PRRFICTQAP 270

  Fly   985 LPNTIFEFWLMIYQNTQRYIRRCVDGGSSSSPHVDREQILQQYFQKIVMLTNFTEANRQKCAVYF 1049
            |..||.|||.||......|                           ||||....|..:.|.|.||
 Worm   271 LNGTIEEFWKMIIVTGIEY---------------------------IVMLCELVEKGKPKSAEYF 308

  Fly  1050 PIELNEIFAVAAKCEVFQLSAAARDYFDRYLTPTFVPDTVVASSDAIDYEISGRHIGVESVKVTL 1114
            |.::.:...:...|.|.:.|....|            .|:|.|                :::::.
 Worm   309 PSQIGQTTKIGRLCTVTKESRVDID------------KTLVMS----------------TMRISK 345

  Fly  1115 EGDLLEALPAQGSFFLIKNVGIVRRNGYSVRKLVLLYCIRVPQSASYHLQKIYCYHYWYPDWPDH 1179
            .||                        .:|.|:|                    .|..:.:||||
 Worm   346 PGD------------------------NAVVKIV--------------------KHIHWRNWPDH 366

  Fly  1180 HSPRDINTLLDTCLHVLNLGKCESEFDIYDDTRSERNAHLAAQRLEIYQQDIFNAVQPLPVIHCS 1244
            ..|       |..|....|                         |.:    :.|..:|: |:|||
 Worm   367 GVP-------DNFLSPFRL-------------------------LTV----VKNCTKPI-VVHCS 394

  Fly  1245 AGIGRTGCFTAILNAVRQLRQSLAYSLTGMLTKSLTSSSTEEYHNPTDSDSSFTCNTIRHISHIL 1309
            ||:||||....||                ::.:|:                   |
 Worm   395 AGVGRTGTLALIL----------------IILESI-------------------C---------- 414

  Fly  1310 DHRDAEAVKTPPSFDRLPKMPDIFVDVLGIVCNLRLQRGGMVQNSEQYELIHRAICLYLKRTLAL 1374
                               :|| |:.|..::..||.:|...||...||...||.:..|    |||
 Worm   415 -------------------LPD-FIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEY----LAL 455

  Fly  1375 RRF 1377
            :::
 Worm   456 KKY 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	PTP_DSP_cys	919..1362	CDD:475123	86/445 (19%)
ZK354.8	NP_500775.1	PTPc	200..451	CDD:214550	97/479 (20%)