Protein Alignment PTP-ER and C46A5.1

DIOPT Version :10

• Sequence 1: NP_726092.1
• Gene: PTP-ER / 37461
• FlyBaseID: FBgn0016641
• Length: 1377
• Species: Drosophila melanogaster
• Sequence 2: NP_501277.1
• Gene: C46A5.1 / 183497
• WormBaseID: WBGene00016698
• Length: 497
• Species: Caenorhabditis elegans
• Alignment Length: 677
• Identity: 111/677 - (16%)
• Similarity: 216/677 - (31%)
• Gaps: 270/677 - (39%)

  Fly   716 AANQAP----HQR----KFFSTENLNSSKANSQKFFGQVCFGSASDLQPNPQQDSVREDQAIGAT 772
            |.:|||    |:|    |...|.|..:.|.:.:|        |.|..:..|:.         |.:
 Worm     3 AVDQAPKKKSHERKRKEKRVHTGNGTAKKHHKRK--------SRSKSKNKPKN---------GLS 50

  Fly   773 CTCAGTVRNI---------------MTRPLSPQTTSEEFKIYLA-SIQMLQSASNPLN------- 814
            | |....:..               :.:||:|....:..::.|. ::::.::...|.|
 Worm    51 C-CRKKKKKSKKSKSKVTKKQPKKKVIKPLAPVPNEQLGEVVLVKNVKLPETPQKPENDTPVKDG 114

  Fly   815 -----------QFDLIRLNYVFDHSYQTNRNIIEQPPVLGSNARDVETPTDMVPPSSEDSELLAS 868
                       :.:|.:.::...:....:.|..|:.    ...::|::|.|:     :|.....|
 Worm   115 LKPPRTTNSVEKINLSKESFNLSNEKIASDNGTEEK----MEKKNVDSPADI-----QDGLKGKS 170

  Fly   869 YQTVVSRMAQ---------------PIPELKENEQKRIFRDLHKEFWDLPLNHQEK------PMV 912
            .|....::.|               .|.:.|..:.|.:.::..|:..::.:|..||      |.:
 Worm   171 KQKSEEKVHQKAKDDAKRGDECNKFKISDEKLTKWKLVAQETLKDDANIAVNEFEKVSGYLPPHI 235

  Fly   913 -----FGSQTKNRYKTILPNENSRVLLESESSELTSLLGEIKRTSSVTASEDLPYINANYIKGPD 972
                 ..:..|||:..::..::|||.|...|                       ||:||::....
 Worm   236 SKNHFVSNMDKNRFVDVICMDHSRVKLTDSS-----------------------YIHANWVDLNS 277

  Fly   973 YVSKCYVATQGPLPNTIFEFWLMIYQNTQRYIRRCVDGGSSSSPHVDREQILQQYFQKIVMLTNF 1037
              ||..:.||.||.:|..:||.|                           |:.|..:.::::...
 Worm   278 --SKKAILTQLPLSHTASDFWQM---------------------------IIDQKIKCVLLIMTD 313

  Fly  1038 TEANRQKCAVYFPIELNEIFAVAAKCEVFQLSAAARDYFDRYLTPTFVPDTVVASSDAIDYEISG 1102
            .|.|:......||                                        .:.|.:.:|  .
 Worm   314 GEFNKFGGNSVFP----------------------------------------QNQDFLKFE--D 336

  Fly  1103 RHIGVESVKVTLEGDLLEALPAQGSFFLIKNVGIVRRNGYSVRKLVLLYCIRVPQSASYHLQKIY 1167
            |.|.|                  |.|   |.|.:.:  |::::.|          |.|....|.:
 Worm   337 RFIRV------------------GEF---KQVELGK--GWNLKVL----------SVSNGTYKTF 368

  Fly  1168 CYHYWYPDWPDHHSPRDINTLLDTCLHV-----------LNLGKC--ESEFDIYDDTRSERNAHL 1219
            .:.:.|.:||....|.|:..:.....::           :::..|  ...|.:::      .||:
 Worm   369 IHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTDGHPPVYMSMSGCGRAGTFALFE------TAHM 427

  Fly  1220 AAQRLEIYQQDIFNAVQPLPVIHCSAGI--GRTGCFTAILNAVRQLRQ-SLAYSLTG--MLTKSL 1279
            :          :.|....|.::.|...:  ||       |::|:.|.| |:.|:|..  :|...:
 Worm   428 S----------LHNEQPSLNMVKCLENVRNGR-------LHSVQNLSQFSVVYTLIAEHVLGNGI 475

  Fly  1280 TSSSTEEYHNPTDSDSSFTCNTIRHIS 1306
            .....||..|..|       |.:|.::
 Worm   476 GKKDVEEQENSID-------NILRQLT 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	PTP_DSP_cys	919..1362	CDD:475123	69/406 (17%)
C46A5.1	NP_501277.1	Y_phosphatase	243..468	CDD:459674	63/374 (17%)