Protein Alignment PTP-ER and K09F6.3

DIOPT Version :10

• Sequence 1: NP_726092.1
• Gene: PTP-ER / 37461
• FlyBaseID: FBgn0016641
• Length: 1377
• Species: Drosophila melanogaster
• Sequence 2: NP_001342012.1
• Gene: K09F6.3 / 173583
• WormBaseID: WBGene00019586
• Length: 1391
• Species: Caenorhabditis elegans
• Alignment Length: 1471
• Identity: 265/1471 - (18%)
• Similarity: 449/1471 - (30%)
• Gaps: 555/1471 - (37%)

  Fly   136 SSGEERVSGRGIDKENT-MPKGGSVDQ-----DLENSLYLS----------------------KS 172
            ||..:|:|...:|::.| .|.|.|:::     .:.||:||:                      .|
 Worm    38 SSTTDRMSPHRVDRQTTDDPLGFSINRMQKISRIVNSIYLTAELTAGTANTYDLIAEFFNFGPDS 102

  Fly   173 EHNSPTILFKDESSTTPGLEA-----SRLSYSP----------KLLSSINNLNVSGSPLNIINS- 221
            .:...:|..|:..|   |||.     |.|:|:.          .|:.....:...||..:|.::
 Worm   103 YNKLQSIDMKELKS---GLEEIVSIHSELTYTDIDKRAEQRFRHLIEIRKEVEGVGSLEDIKDAQ 164

  Fly   222 AGYKNGNFFRFPEIDHVVQDAPMDTVCLEEATRRDRSPALAEPPEQQQQKSEGRKNRKNKNNLTI 286
            |.||:       |:: ..:....||..:||.....::...|....::....|
 Worm   165 ANYKS-------ELE-TFKKTTFDTAGIEEFQNAVKNFIGAAADVEKYSNLE------------- 208

  Fly   287 RITDVPIKNSSQPSPLPKPKTPTIKSTKEK-ARSLDS---------AANESE----LSIVVHNIT 337
            ::|||.|..:       :|...|:|::.|. |:|..|         ..|.||    :|.:|....
 Worm   209 KLTDVDIMYA-------RPLIYTLKTSIENLAKSYSSINSFDDFEKIRNPSEFVDPISKIVSGYK 266

  Fly   338 ESHGSCDDMET--GQSQPSTSVIHHHLHLQQPASAIH--STSLSRLDSHLSLANQRRTPRRKSPG 398
            :.:.|...:|.  ..::...|..::...|:..||...  .:.:..|.:.:.:......|:.....
 Worm   267 KYNASRTTIERDGNFAKGMQSNANNMKRLENVASVFEGLGSFVKNLQAVIDVRQTMHLPKYTVGF 331

  Fly   399 INTT------------DWLMYHRKQNPYQVQPTHCSSTTQSSLDSDASLTPSLGD----FELKSA 447
            |:.|            ||:.               |.|.:..|:...:|...:||    .|....
 Worm   332 IDGTFDPKKVVTDLEDDWVQ---------------SVTHEMDLNRTINLLLPIGDHVSAIEASFL 381

  Fly   448 CSVDGGSKFGIGASLAPRSAHKHNQLLHSSSTNLKTLPEC----LTLVEFSSSGGGPKESPFKQK 508
            .|....|||..|...:.......:..:.|..:..|.:.||    ||.:|             ..|
 Worm   382 SSSSKQSKFFTGFKSSETEVSPVDGSIDSIISTSKKVSECIIAPLTYLE-------------SIK 433

  Fly   509 SMDLPMPTLQA-KTTVST--SSMNLLQRRGSNHSLTLNLHSSCG-------------NLMNSGL- 556
            .:::.:..::: |.||.|  .:..|:....:|..:...:.:.|.             .:...||
 Worm   434 EVEILLQAIESLKKTVDTLVGTKELVNWVKTNDVVLKEVEALCSYTDEEKKDFESSVPIKLKGLK 498

  Fly   557 SHSNY-SLGSILNSKSSCNLDAGTASQIRADQLPQSHLLGSSQG--------------------- 599
            |..|| ||...|| :||...||..:.::.......:::||..|.
 Worm   499 SSENYTSLIKTLN-QSSLFADAVFSEKLSTTGQETAYILGGLQSLDAFYNSATDHIAFFDCLLNV 562

  Fly   600 -----------------------SRQG------LFRRRGSNHSITLKTG---------------- 619
                                   .|.|      ||  ..||....|||.
 Worm   563 AYYDLIPLAIDTLNKVRKMDVQPIRDGIDVVNDLF--NVSNQLDELKTKLRELNDPNFSIAETPL 625

  Fly   620 -----HTTTSCGDLNSMQQLQ-------------QQQAMLSAEKYNRLNMRTNSTGSGS------ 660
                 ||||....:..:.:::             :...|:..|..|......|....||
 Worm   626 SNPSLHTTTIGLSVRGVIRMKDEIDHRSDFDVVIENAEMVDQEMKNTGKKAINMVEFGSRLKKLK 690

  Fly   661 ----GSGSNV----------PTPK--------RGLLERRGSNQSLTLNMGSI-----LGGAAGTE 698
                |..||:          .||.        :..|:..|.:..|...|.::     .|..|.|:
 Worm   691 SELEGWKSNITVGGAHRIRRSTPSLADYAHIFQNALKVGGVDDDLKKLMDAVKDFEKTGKDAATK 755

  Fly   699 IQMTDIVQPKVTVCSCAAANQAPHQRKFFST--------------------------ENLNSSKA 737
            :::.::      :.|..:.|....|...|:|                          ..:.||..
 Worm   756 VKLKEV------IASLNSLNSIGLQLSSFATPFTAIGQSFSALDAFFVSNGKIITTPAPIVSSSG 814

  Fly   738 NSQKFFGQVCFGSASDLQPN----------PQQDSVREDQAIGATC------------TCAGTVR 780
            .||:  ||...|.:..|||:          |..:|......||..|            .|.....
 Worm   815 ASQE--GQKSAGGSMTLQPSQTVSVTTTEEPMDESTNLMIFIGIGCGIVLVSALIVAVVCFYKRN 877

  Fly   781 NIMTRPLSPQTTSEEFKI--YLASIQMLQSASNPLNQFDLIRLNYVFDHSYQTNRNIIEQ-PPVL 842
            .|....:...|..|:.||  .||: |..|:......:.::..|....|:..|....|.|: ...:
 Worm   878 KIANDDMEQGTKIEKEKIARELAA-QEAQNIEAEKKKKEIKDLEAKVDYEKQKGEKIKEEAEKEI 941

  Fly   843 GSNARDVETPTDMVP-------PSSEDSELL---------------ASYQTVVS--RMAQPIPE- 882
            ..:.:.||  .|.:|       |:.||:..|               |.||...|  |:|...|.
 Worm   942 QDHRKKVE--DDKLPKFYDIRSPTIEDATALEGDKGATNNGKLPLKAMYQFCKSILRIANLAPNN 1004

  Fly   883 -LKENEQKRIFRDLHKEFWDLPLNHQEKPMVFGSQTKNRYKTILPNENSRVLLESESSELTSLLG 946
             :.|:|:                 :.|         ::||..:|...::|:|::
 Worm  1005 AIVESEK-----------------YSE---------QDRYSDVLCGMDNRILID----------- 1032

  Fly   947 EIKRTSSVTASEDL--------PYINANYIKGPDYVSKCYVATQGPLPNTIFEFWLMIYQNTQRY 1003
                       ||:        .||||||::.|:  ....:.||.|:..|  |.:.......::.
 Worm  1033 -----------EDVCRRCYFKDQYINANYLELPN--GNRMILTQAPMSRT--EHFKPEKDKKRKN 1082

  Fly  1004 IRRCVDGGSSSSPHVDREQILQQYFQKIV--------MLTNFTEANRQKCAVYFPIELNEIFAVA 1060
            :....|.....|..|   |.:.:::|.||        ||.:|.|...:||:.|||:|
 Worm  1083 LYSLSDEEEEISYLV---QTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLE-------- 1136

  Fly  1061 AKCEVFQLSAAARDYFDRYLTPTFVPDTVVASSDAIDYEISGRHIGVESVKVTLEGDLLEALPAQ 1125
                        :|...::.........|             :|...:.|..||
 Worm  1137 ------------KDGKQKFHNVNVCTTNV-------------QHPSADVVLRTL----------- 1165

  Fly  1126 GSFFLIKNVGIVRRNGYSVRKLVLLYCIRVPQSASYHLQKIYCYHYWYPDWPDHHSPRDINTLLD 1190
                                 ::..|   :.:....|..|    ||.|..|.:.::|
 Worm  1166 ---------------------VITSY---LGEKKKTHTVK----HYSYKGWIEKNAP-------- 1194

  Fly  1191 TCLHVLNLGKCESEFDIYDDTRSERNAHLAAQRLEIYQQDIFNAVQPLPVIHCSAGIGRTGCFTA 1255
                       |...:|.:..|..||:...                   |:|||.||||:..|..
 Worm  1195 -----------ELPREILNIFRVARNSKSL-------------------VVHCSNGIGRSAAFVF 1229

  Fly  1256 ILNAVRQLRQSLAYSLT------GMLTKSLTSSSTEEYHNP 1290
            .....:::.:||..:.|      .:||: |..|.....|.|
 Worm  1230 AEFVYQKMIRSLDTTSTVNLDFLSLLTE-LRHSRPRAIHTP 1269

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	PTP_DSP_cys	919..1362	CDD:475123	73/394 (19%)
K09F6.3	NP_001342012.1	WSN	56..124	CDD:197734	14/70 (20%)
		PTPc	992..1281	CDD:214550	80/444 (18%)