Protein Alignment PTP-ER and egg-5

DIOPT Version :9

• Sequence 1: NP_726092.1
• Gene: PTP-ER / 37461
• FlyBaseID: FBgn0016641
• Length: 1377
• Species: Drosophila melanogaster
• Sequence 2: NP_491316.1
• Gene: egg-5 / 172007
• WormBaseID: WBGene00020035
• Length: 753
• Species: Caenorhabditis elegans
• Alignment Length: 906
• Identity: 153/906 - (16%)
• Similarity: 268/906 - (29%)
• Gaps: 377/906 - (41%)

  Fly   423 STTQSSLDSDASLTPS-------LGDFELKSACSVDGGSKFGIGASLAPRSAHKHNQLLHSSSTN 480
            |..::..:|:::|:.|       |...:.:|...::|.|:  ..|...||.|..    .:::.:.
 Worm    60 SCMRARFNSESTLSKSFRKKVKKLAQKDRRSKERLNGNSE--EDAIEVPRGAPS----TYAAPSK 118

  Fly   481 L---KTLPECLTLVE------FSSSGGGPKESPFKQKSMDLPMPTLQAKTTVSTSSMNLLQRRGS 536
            |   |.| :||...:      ...||.|......|....|:.|....|:|.:......:::.|.:
 Worm   119 LRKSKAL-DCLVSEKPKDEGRSEDSGHGADIEMAKGHFNDVRMKVFAARTAMQVEPALVMKTRKA 182

  Fly   537 --NHSLTLNLHSSCGNLMNSGLSHSNYSLGSILNSK----SSCNLDAGTASQIRADQLPQSHLLG 595
              ..:..|..|.|.|...    .|:.|.:.:...|:    :.||.        :..:...::|:.
 Worm   183 LEMKNAVLENHQSPGAFS----LHAAYKIAASAESRVGSITPCNK--------KVTKEAMANLIR 235

  Fly   596 SSQGSRQGLFRRRGSNHSITLKTGHTTTSCGDLNSMQQLQQQQAMLSAE-------KYNRLNMRT 653
            ||....:           ||                     |:.:.|::       :|..:.||.
 Worm   236 SSYDDTE-----------IT---------------------QELLFSSKFDSKWKGRYTDIYMRR 268

  Fly   654 NSTGSGSGSGSNVPTPKRGLLERRGSNQSLTLNMGSILGGAAGTEIQMTDIVQPKVTVCSCAAAN 718
            :..|.         .|||                          .:.....|.|..::|.....|
 Worm   269 DENGK---------KPKR--------------------------PVNGQGWVMPLKSICEKFGIN 298

  Fly   719 QAPHQRKFFSTENLNSSKANSQKFFGQVCFGS-----ASDLQPNPQQDSVREDQAIGATCTCAGT 778
            ..     ||:...::...|..|....::....     .||:.|    ::|:.:           |
 Worm   299 ST-----FFTNHRIDLKSARDQVLLMRLLSHDQTSTWISDIHP----EAVKNE-----------T 343

  Fly   779 VRNIMTRPLSPQTTSEEFKIYLASIQMLQSASNPLNQFDLIRLNYVFDHSYQTNRNIIEQPPVLG 843
            :...:.|.|...|..:..:.:.|         |.|...|.:|:...|.::.:..:.:.
 Worm   344 LAEYLLRELDASTMQKRVQAFKA---------NVLADRDRVRVAGQFYNNIRIGKRMF------- 392

  Fly   844 SNARDVETPTDMVPPSSEDSELLASY-QTVVSRMAQPIPELKENEQKRIFRDLHKEFWDLPLNHQ 907
            ..||.                  |.| .|::..|.:.. |:.||....|           |..|.
 Worm   393 GAARK------------------AKYLSTIIGGMERRF-EILENSVNHI-----------PFTHS 427

  Fly   908 EKPMVFGSQTKNRYKTILPNENSRVLLESESSELTSLLGEIKRTSSVTASEDLPYINANYIKGPD 972
            ...   .:|.|.|...:...:::|:.|:....:   .||:              :|:||.|.|..
 Worm   428 ASD---NNQEKCRNPRVHCRDSTRIALQFPRGQ---YLGD--------------FIHANRISGKP 472

  Fly   973 YVSKCYVATQGPLPNTIFEFWLMIYQNTQRYIRRCVDGGSSSSPHVDREQILQQYFQKIVMLTNF 1037
            ..:: ::.||.|:.||:.:||.|::|....|                           |||||:.
 Worm   473 LFNE-FIMTQAPMKNTVDDFWRMVWQEEVPY---------------------------IVMLTSR 509

  Fly  1038 TEANRQKCAVYFPIELNEIFAVAAKCEVFQLSAAARDYFDRYLTPTFVPDTVVASSDAIDYEISG 1102
            .|..|  |..|:|                                       .:.||.
 Worm   510 KEPER--CEYYWP---------------------------------------KSPSDP------- 526

  Fly  1103 RHIGVESVKVTLEGDLLEALPAQGSFFLIKNVGIVRRNGYSVRKLVLLYCIRVPQSASYHLQKIY 1167
                    .||:.|.|           .|:|.|:              |....|.....||:.|
 Worm   527 --------AVTVPGGL-----------RIENFGV--------------YQAPDPLFRVTHLRLI- 557

  Fly  1168 CYHYWYPDWPDHHSPR---DIN--TLLDTCLHVLNLGKCESEFDIYDDTRSERNAHLAAQRLEIY 1227
                 .||..:.|...   |:|  :.:.:.|::|.|
 Worm   558 -----GPDREERHVEHWQGDVNNSSNMYSPLNILRL----------------------------- 588

  Fly  1228 QQDIFNAVQPLPVIHCSAGIGRTGCFTA-----------------ILNAVRQLRQSLAYSL 1271
               :.||.:|: |||...|:.|..|..|                 :..||:.|||...:|:
 Worm   589 ---LRNASKPV-VIHDHLGVSRAACLVAAEIAICSLLRGPTYKYPVQRAVQFLRQRRPFSI 645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	Y_phosphatase	916..1364	CDD:278528	70/378 (19%)
		PTPc	917..1364	CDD:238006	69/377 (18%)
egg-5	NP_491316.1	PTPc	407..660	CDD:214550	77/419 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900