Protein Alignment PTP-ER and egg-4

DIOPT Version :9

• Sequence 1: NP_726092.1
• Gene: PTP-ER / 37461
• FlyBaseID: FBgn0016641
• Length: 1377
• Species: Drosophila melanogaster
• Sequence 2: NP_491269.1
• Gene: egg-4 / 171980
• WormBaseID: WBGene00020652
• Length: 753
• Species: Caenorhabditis elegans
• Alignment Length: 850
• Identity: 149/850 - (17%)
• Similarity: 247/850 - (29%)
• Gaps: 343/850 - (40%)

  Fly   506 KQKSMDLPMPTLQAKTTVSTS---SMNLLQRRGSNHSLTLNLHSSCGNLMNSGL-----SHSNYS 562
            :||.:........:::|:|.|   .:..|.::.......||     ||.....:     :.|.|:
 Worm    55 QQKGVSCMRARFNSESTLSKSFRKKVKKLAQKDRRSKERLN-----GNSEEDAIEVPRGAPSTYA 114

  Fly   563 LGSILNSKSSCNLDAGTASQIRADQLPQSHLLGSSQGSRQGLFRRRGSNH--SITLKTGHTTTSC 625
            ..|.|  :.|..||.                |.|.:...:|  ||..|.|  .|.:..||.....
 Worm   115 APSKL--RKSKALDC----------------LVSEKPKDEG--RREDSGHGADIEMAKGHFNNVR 159

  Fly   626 GDLNSMQQLQQQQAMLSAEKYNRLNMRT----NSTGSGSGS---------------GSNVPTPKR 671
            ..:.:.:...|.:..|..:....|.|:.    |....|:.|               ||..|..|:
 Worm   160 MKVFAARTAMQVEPALVMKTRKALEMKNAVLENHQSPGAFSLHAAYKIAASAESRVGSITPCNKK 224

  Fly   672 GLLER-----RGSNQSLTLNMGSILGGAAGTEI--QMTDI--------------------VQPKV 709
            ...|.     |.|.....:....:......|:.  :.|||                    |.|..
 Worm   225 VTKEAMANLIRSSYDDTEITQELLFSSKFDTKWKGRYTDIYMRRDENGKKPKRPVNGQGWVMPLK 289

  Fly   710 TVCSCAAANQAPHQRKFFSTENLNSSKANSQKFFGQVCFGS-----ASDLQPNPQQDSVREDQAI 769
            ::|.....|..     ||:...::...|..|....::....     .||:.|    ::|:.:
 Worm   290 SICEKFGINST-----FFTNHRIDLKSARDQVLLMRLLSHDQTSTWISDIHP----EAVKNE--- 342

  Fly   770 GATCTCAGTVRNIMTRPLSPQTTSEEFKIYLASIQMLQSASNPLNQFDLIRLNYVFDHSYQTNRN 834
                    |:...:.|.|...|..:..:.:.|         |.|...|.:|:...|.::.:..:.
 Worm   343 --------TMAEYLLRELDASTMQKRVQAFKA---------NVLADRDRVRVAGQFYNNIRIGKR 390

  Fly   835 IIEQPPVLGSNARDVETPTDMVPPSSEDSELLASY-QTVVSRMAQPIPELKENEQKRIFRDLHKE 898
            :.       ..||.                  |.| .|::..|.:.. |:.||....|
 Worm   391 MF-------GAARK------------------AKYLSTIIGGMERRF-EILENSVNHI------- 422

  Fly   899 FWDLPLNHQEKPMVFGSQTKNRYKTILPNENSRVLLESESSELTSLLGEIKRTSSVTASEDLPYI 963
                |..|....   .:|.|.|...:...:::|:.|:....:   .||:              :|
 Worm   423 ----PFTHSASD---NNQEKCRNPRVHCKDSTRIALQFPRGQ---YLGD--------------FI 463

  Fly   964 NANYIKGPDYVSKCYVATQGPLPNTIFEFWLMIYQNTQRYIRRCVDGGSSSSPHVDREQILQQYF 1028
            :||.|.|....:: ::.||.|:.||:.:||.|::|....|
 Worm   464 HANRISGKPLFNE-FIMTQAPMKNTVDDFWRMVWQEEVPY------------------------- 502

  Fly  1029 QKIVMLTNFTEANRQKCAVYFPIELNEIFAVAAKCEVFQLSAAARDYFDRYLTPTFVPDTVVASS 1093
              |||||:..|..|  |..|:|                                       .:.|
 Worm   503 --IVMLTSRKEPER--CEYYWP---------------------------------------KSPS 524

  Fly  1094 DAIDYEISGRHIGVESVKVTLEGDLLEALPAQGSFFLIKNVGIVRRNGYSVRKLVLLYCIRVPQS 1158
            |.               .||:.|.|           .|:|.|:              |....|..
 Worm   525 DP---------------AVTVPGGL-----------RIENFGV--------------YQAPDPLF 549

  Fly  1159 ASYHLQKIYCYHYWYPDWPDHHSPR---DIN--TLLDTCLHVLNLGKCESEFDIYDDTRSERNAH 1218
            ...||:.|      .||..:.|...   |:|  :.:.:.|::|.|
 Worm   550 RVTHLRLI------GPDREERHVEHWQGDVNNSSNMYSPLNILRL-------------------- 588

  Fly  1219 LAAQRLEIYQQDIFNAVQPLPVIHCSAGIGRTGCFTA-----------------ILNAVRQLRQS 1266
                        :.||.:|: |||...|:.|..|..|                 :..||:.|||.
 Worm   589 ------------LRNASKPV-VIHDHLGVSRAACLVAAEIAICSLLRGPTYKYPVQRAVQFLRQR 640

  Fly  1267 LAYSL 1271
            ..:|:
 Worm   641 RPFSI 645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	Y_phosphatase	916..1364	CDD:278528	70/377 (19%)
		PTPc	917..1364	CDD:238006	69/376 (18%)
egg-4	NP_491269.1	PTPc	407..660	CDD:214550	77/418 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900