Protein Alignment PTP-ER and LOC1278795

DIOPT Version :10

• Sequence 1: NP_726092.1
• Gene: PTP-ER / 37461
• FlyBaseID: FBgn0016641
• Length: 1377
• Species: Drosophila melanogaster
• Sequence 2: XP_061497222.1
• Gene: LOC1278795 / 1278795
• VectorBaseID: AGAMI1_005171
• Length: 1471
• Species: Anopheles gambiae
• Alignment Length: 1599
• Identity: 298/1599 - (18%)
• Similarity: 484/1599 - (30%)
• Gaps: 603/1599 - (37%)

  Fly    21 TPRPTHAAPSDTTPLE-----------AGEDAESNKSTPYFTPLEYLQTS--------------- 59
            ||.|| |||:.:...|           |.|.|.|::.......:|..|:|
Mosquito   213 TPAPT-AAPARSVVAEGSEGESVSSSGASESAGSSEPRASEPSVESEQSSVPEQQQSLEQSGQQL 276

  Fly    60 --FEFPSPTVEVGGGVPGFPEHEDQEEEVFT-------PRQFTITSPHPAAHVHH---PSSSQSP 112
              ||..|...|:...:.|..:..|.|..|.|       |...||:...||.....   |::..|.
Mosquito   277 GTFEQDSLAEEINSQLRGDGDDNDDEVAVTTTVVPPLAPEVETISPASPANRSDDGSAPAAMVSD 341

  Fly   113 TLGRKFKRLSQYDRRSCSPHINTSSGEERVSGRGIDKENTMPKGGSVDQDLENSLYLSKS----- 172
            ..|.:.: ||:|          |:.......|..:.|||:..:..|.:.|.|:.|....:
Mosquito   342 GAGERIE-LSRY----------TAPSNSSPDGTALLKENSAVEIDSSNDDEEDRLTTEAALPVTT 395

  Fly   173 ------------------EHNSPTILFKDESSTTPGLEAS----RLSYSP------KLLSSINNL 209
                              |.||...:.:.:..|....|:|    |....|      |.|...|..
Mosquito   396 LSALDVATDDASRASESVERNSSLSVERTQIETNAYEESSNEVERNQTLPARAKKGKFLDQFNEE 460

  Fly   210 NVSGSPLNIINSAGYKNGNFFRFPEIDHVVQDAPMDTVCLEEATRRDRSPALAEPPEQQQQKSE- 273
            ....:.:|:.|.|.:                  .:..:.:.|..:.|...|::|..|..:..||
Mosquito   461 TTEDNDINLPNGAAW------------------ALAGMRMVERKQSDVGQAVSESTETVRDDSEN 507

  Fly   274 --GRKNRKNKNNLTIRITDVPIKNS-------SQPSPLPKP-------KTPTIKS---------- 312
              |....|...:..|.:.:....||       |...|:...       |.|.:::
Mosquito   508 VVGNNTLKQLMDWAIIMKEADFANSSFVRSTVSSDEPVGAKDRRTYANKVPAVENGADVLSEENR 572

  Fly   313 ----------TKEKARSLDSAANESELSIVVHNITESHGSCDDMETGQ----------SQPSTSV 357
                      ||..|.....||...:.::|......|..|.|  .:||          |..||::
Mosquito   573 LTAIVTETAPTKPAAEGESVAAETEDGNVVDTTFVPSTESPD--RSGQELEDFKFEDRSTSSTTM 635

  Fly   358 IHHHLHLQQPASAIHSTSLSRLDSHLSLANQRRTPR-RKSPGINTTDWLMYHRKQNPYQVQPTHC 421
            .:....:.:..:|:.:|:....:...::.....:|| |.:|.|.||                  .
Mosquito   636 ANEVASISESVNAMPTTTRRTYEVSENVDESEVSPRVRNTPEIRTT------------------T 682

  Fly   422 SSTTQSSLDSDASLTPSLGDFELKSACSVDGGSKFGIGASLAPRSAHK------HNQLLHSSST- 479
            ::||.::..||.|  .:.|.||....      :.:...|.:..|:...      ...:...:||
Mosquito   683 TTTTSAAQRSDVS--TAFGMFEDVPV------TTYSPAAPILRRTEQTTPPIPLTTMITRIASTM 739

  Fly   480 ---NLKTL-PEC-------LTLVEFSSS--GGG--------PKESPFKQKSMDLPMPTLQAKTTV 523
               .|.|: |:.       |.:.|::|:  |.|        ..|||....:.|......|..|..
Mosquito   740 PVRRLTTMQPDFAAITTTDLPVREYASTDMGSGATFTTTVASSESPIVHDTADSKPLDQQDSTES 804

  Fly   524 STSSMNLLQRR-----------GSNHSLTLNLHSSCGNLMNSGLSHSNYSLGSILNSKSSCNLDA 577
            |..:.|||.|.           .|..::..||.|:   .:.:.:...:.|.|..|..:||...:.
Mosquito   805 SEVNQNLLNRTEDKLMVATSTVASVTTVVPNLSSA---TLTNNVEFDDASAGESLIGQSSVTTER 866

  Fly   578 GTASQIRADQ-----------LPQSHLLGSSQGSRQGLFRRRGSNHSITLKTGHTTTSCGDLNSM 631
            ....|:..|:           |...|:..:.               |.|:....||||....:::
Mosquito   867 SDPPQMTTDESADDGGKVPIVLDDKHVYDTI---------------STTVAAATTTTSTSSPSAI 916

  Fly   632 QQLQQQQAMLSAEKYNRLNMRTNSTGSGSGSGSNVPTPKRGLLERRGSNQSLTLNMGSILGGAAG 696
                                  .:|.|.||||.:|.........||..::|:|.
Mosquito   917 ----------------------TTTESSSGSGQSVGVSAEAYTTRRTIDRSMTT----------- 948

  Fly   697 TEIQMTDIVQPKVTVCSCAAANQAPHQRKFFSTENLNSSKANSQKFFGQVCFGSASDLQPNPQQD 761
            ||:...:.|.                :..:....|:.::..:          |.||......|.|
Mosquito   949 TELSEEESVT----------------EEDYIELNNVPATGGS----------GGASQGDGQNQTD 987

  Fly   762 SVREDQAIGATCTCAGTVRNIMTRPLSPQTTSEEFKIYLASIQMLQSASNPLNQFDLIRLNYVFD 826
            ...:.|.:.......||.......|    ...|:..:.:|.:..:.|.        ::.|..:..
Mosquito   988 LSGQQQGVAPKQGINGTTEQSQGEP----AAEEDSSVVVAVVASIVSV--------IVVLLLIAA 1040

  Fly   827 HSYQTNRNII----EQPPVLGSNARDVETPTDMVPPSSEDSELLASYQTV-----VSRMAQ---- 878
            ..|.....|:    :.....|...|.|.     :...|.|:  ::.|.:|     .:||::
Mosquito  1041 FMYYPPLQIVFRKRQNQVSYGQRCRPVG-----LDAYSLDN--VSVYNSVRRKGNTARMSKRSYG 1098

  Fly   879 ----PIPELKEN-----------EQKRIFRDLHKEFWDLPLNHQEKPMVFGSQTKNRYKTILPNE 928
                ..|..|.|           ..|....|..||..::.....|.|.  |.:.||||..::|..
Mosquito  1099 NSAFEDPNFKTNPLTVAELANIIHNKTAIYDEFKEIPNVTARADEVPE--GCEDKNRYANVVPLP 1161

  Fly   929 NSRVLLESESSELTSLLGEIKRTSSVTASEDLPYINANYIKGPDYVSKCYVATQGPLPNTIFEFW 993
            .:||              .:||.:.   .|...|||||::|||...:..|:|.|.|:.|||.:||
Mosquito  1162 ETRV--------------HLKRMND---DEKTEYINANFVKGPKDSANYYIACQAPMENTINDFW 1209

  Fly   994 LMIYQNTQRYIRRCVDGGSSSSPHVDREQILQQYFQKIVMLTNFTEANRQKCAVYFPIELNEIFA 1058
            .|:::...:.                           |:|.|:.:|...:|||.|.|
Mosquito  1210 RMVWEQNSKV---------------------------IIMATDLSENGVEKCAEYLP-------- 1239

  Fly  1059 VAAKCEVFQLSAAARDYFDRYLTPTFVPDTVVASSDAI-DYEISGRHIGVESVKVTLEGDLLEAL 1122
                                       |..|:.:|... |::::
Mosquito  1240 ---------------------------PSVVLDNSRTFGDFQLT--------------------- 1256

  Fly  1123 PAQGSFFLIKNVGIVRRNGYSVRKLVLLYCIRVPQSASYHLQKIYCYHYWYPDWPDHHSPRD--- 1184
                    :||    |.|    ::...:..:.:..:.|.:|::|  .|:|| .|||...|.|
Mosquito  1257 --------LKN----REN----KEKYTISTVHMRHTPSNNLREI--MHFWY-QWPDTGVPIDESS 1302

  Fly  1185 -INTLLDTCLHVLNLGKCE-SEF-DIYDDTRSE-----------------------RNA------ 1217
             |..||:...| |.|...| :|| .|.:::..:                       .||
Mosquito  1303 IIGMLLEARTH-LKLSPSELAEFATIVEESEEQPSEQPGVGNGTDNSSNNNNNNNNNNATSNGTP 1366

  Fly  1218 -------------------HLAAQRLEIYQQDIFNAVQPLPVIHCSAGIGRTGCFTAILNAVRQL 1263
                               |.:.||.:          .|| .:|||.|.||||...|...|:|.|
Mosquito  1367 AGAGKEPASIVSNGGTMDKHKSLQRTQ----------GPL-TVHCSPGTGRTGTLVACDIALRLL 1420

  Fly  1264 RQSLAYSLTGMLTKSLTSSSTEEYHNPTDSDSSFTCNTIRHISHILDHRDAEAVKTPPSFDRLPK 1328
                                                                  :.||....||:
Mosquito  1421 ------------------------------------------------------EVPPRTVDLPQ 1431

  Fly  1329 MPDIFVDVLGIVCNLRLQRGGMVQNSEQYELIHRAICLY 1367
                      ||..:|..|...|:..||||||:|...:|
Mosquito  1432 ----------IVYYVRRGRASAVRTREQYELIYRVSNVY 1460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	PTP_DSP_cys	919..1362	CDD:475123	99/497 (20%)
LOC1278795	XP_061497222.1	None