Protein Alignment PTP-ER and Ptpn12

DIOPT Version :10

• Sequence 1: NP_726092.1
• Gene: PTP-ER / 37461
• FlyBaseID: FBgn0016641
• Length: 1377
• Species: Drosophila melanogaster
• Sequence 2: NP_476456.2
• Gene: Ptpn12 / 117255
• RGDID: 620894
• Length: 766
• Species: Rattus norvegicus
• Alignment Length: 527
• Identity: 123/527 - (23%)
• Similarity: 177/527 - (33%)
• Gaps: 241/527 - (45%)

  Fly   861 EDSELLASYQTVVSRMAQPIPELKENEQKRIFRD------LHKEFWDLPLNHQEK--PMVFGSQ- 916
            |..|:|..:...|..|..|    ..|.:....||      |..::      ..||  |...|.:
  Rat     2 EQVEILRRFIQRVQAMKSP----DHNGEDNFARDFMRLRRLSTKY------RTEKIYPTATGEKE 56

  Fly   917 ---TKNRYKTILPNENSRVLLESESSELTSLLGEIKRTSSVTASEDLPYINANYIKGPDYVSKCY 978
               .|||||.|||.::|||.|..:                 |.|:|..|||||:|||. |..:.|
  Rat    57 ENVKKNRYKDILPFDHSRVKLTLK-----------------TPSQDSDYINANFIKGV-YGPRAY 103

  Fly   979 VATQGPLPNTIFEFWLMIYQNTQRYIRRCVDGGSSSSPHVDREQILQQYFQKIVMLTNFTEANRQ 1043
            |||||||.||:.:||.||::..                           ...|||.....|..|:
  Rat   104 VATQGPLANTVIDFWRMIWEYN---------------------------VVIIVMACREFEMGRK 141

  Fly  1044 KCAVYFPIELNEIFAVAAKCEVFQLSAAARDYFDRYLTPTFVPDTVVASSDAIDYEISGRHIGVE 1108
            ||..|:|:                       |.:..:  ||.|
  Rat   142 KCERYWPL-----------------------YGEDPI--TFAP---------------------- 159

  Fly  1109 SVKVTLEGDLLEALPAQGSFFLIKNVGIVRRNGYSVRKLVLLYCIRVPQSASYHLQKIYCYHYWY 1173
             .|::.|.:                   ..|..|.:|.|:|.:     |:.|   :::|.:|  |
  Rat   160 -FKISCENE-------------------QARTDYFIRTLLLEF-----QNES---RRLYQFH--Y 194

  Fly  1174 PDWPDHHSPRDINTLLDTCLHVLNLGKCESEFDIYDDTRSERNAHLAAQRLEIYQQDIFNAVQPL 1238
            .:||||..|...:::||    :::|                         :..||:.     :.:
  Rat   195 VNWPDHDVPSSFDSILD----MISL-------------------------MRKYQEH-----EDV 225

  Fly  1239 PV-IHCSAGIGRTGCFTAILNAVRQLRQSLAYSLTGMLTKSLTSSSTEEYHNPTDSDSSFTCNTI 1302
            |: ||||||.||||...||                                       .:|.|.:
  Rat   226 PICIHCSAGCGRTGAICAI---------------------------------------DYTWNLL 251

  Fly  1303 RHISHILDHRDAEAVKTPPSFDRLPKMPDIFVDVLGIVCNLRLQRGGMVQNSEQYELIHRAICLY 1367
            :            |.|.|..|           :|..::..:|.||...||..|||||:||||...
  Rat   252 K------------AGKIPEEF-----------NVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQL 293

  Fly  1368 LKRTLAL 1374
            .::.|.|
  Rat   294 FEKQLQL 300

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	PTP_DSP_cys	919..1362	CDD:475123	102/443 (23%)
Ptpn12	NP_476456.2	PTPc-N12	2..298	CDD:350452	121/523 (23%)
		DUF5585	499..>641	CDD:465521