DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTP-ER and ptprr

DIOPT Version :9

Sequence 1:	NP_726092.1	Gene:	PTP-ER / 37461	FlyBaseID:	FBgn0016641	Length:	1377	Species:	Drosophila melanogaster
Sequence 2:	XP_021330980.1	Gene:	ptprr / 100526652	ZFINID:	ZDB-GENE-101029-2	Length:	639	Species:	Danio rerio

Alignment Length:	1043	Identity:	216/1043 - (20%)
Similarity:	304/1043 - (29%)	Gaps:	549/1043 - (52%)

- Green bases have known domain annotations that are detailed below.

  Fly   379 LDSHLSLANQRRTPRRKSPGINTTDWLMYHRKQNPYQVQPTHCSSTTQSSLDSDASLTPSLGDFE 443
            |.||.     :|.|:|::..:..||    |.:..    ||.|.:.|.:   :.|          |
Zfish    82 LQSHF-----QRAPQRQAELLRNTD----HAENK----QPAHRTLTME---EKD----------E 120

  Fly   444 LKSACSVDGGSKFGIGASLAPRSAHKH-------NQLLHSS----STNLKT-------------- 483
            ::...|..|||         ..:||:.       :.|.|||    :|...|
Zfish   121 IELYVSSVGGS---------DPAAHEEMIRLLNLDNLQHSSGPIATTEASTEKNVFKDHHEKNGI 176

  Fly   484 --------LPECLT--LVEFSSSG--GGPKESPFKQKSMDLPMPTLQAKTTVSTSSMNL--LQRR 534
                    |..|||  |:.||...  ...||.....:.:..|.|        .:..::|  :...
Zfish   177 WGKDGFYVLVICLTIFLIIFSCLMVLYRLKEKEVLDQQLKDPSP--------PSRDVHLAPVPVH 233

  Fly   535 GSNHSLTLNLHSSCGNLMNSGLSHSNYSLGSIL-----NSKSSCNL------DAGTASQIRADQL 588
            |:...|||.         ||.:..|..|..|..     .:..|||:      .:||.|:.:....
Zfish   234 GAQPPLTLK---------NSMVQASRTSKPSATYFPSSTNAPSCNISIHQTPSSGTTSEPQCPSG 289

  Fly   589 PQSHLLGSSQGSRQGLFRRRGSNHSITLKTGHTTTSCGDLNSMQQLQQQQAMLSAEKYNRLNMRT 653
            |.:..|..|.......||.:
Zfish   290 PPAAELKPSVSCTHSPFRMK--------------------------------------------- 309

  Fly   654 NSTGSGSGSGSNVPTPKRGLLERRGSNQSLTLNMGSILGGAAGTEIQMTDIVQPKVTVCSCAAAN 718
                           |..||.||||||.||.|:|.| ||.           |:|    .:|...
Zfish   310 ---------------PVAGLQERRGSNVSLVLDMSS-LGS-----------VEP----LNCGVV- 342

  Fly   719 QAPHQRKFFSTENLNSSKANSQKFFGQVCFGSASDLQPNPQQDSVREDQAIGATCTCAGTVRNIM 783
             .|.:|
Zfish   343 -TPRER----------------------------------------------------------- 347

  Fly   784 TRPLSPQTTSEEFKIYLASIQMLQSASNPLNQFDLIRLNYVFDHSYQTNRNIIEQPPVLGSNARD 848
                             |:.:.|||||..|::..|                            ||
Zfish   348 -----------------ATQEYLQSASRVLSRKQL----------------------------RD 367

  Fly   849 VETPTDMVPPSSEDSELLASYQTVVSRMAQPIPELKENEQKRIFRDLHKEFWDLPLN--HQEKPM 911
            |...|.:                                       ||.||.::|:|  .|::..
Zfish   368 VTQNTHV---------------------------------------LHAEFAEIPMNFVDQKELD 393

  Fly   912 VFGSQTKNRYKTILPNENSRVLLESESSE--LTSLLGEIKRTSSVTASEDLPYINANYIKGPDYV 974
            |....:||||||||||.:|||:|::::|.  |:|                  |||||||:|...|
Zfish   394 VPNHGSKNRYKTILPNPHSRVILKTKNSNDPLSS------------------YINANYIRGYLGV 440

  Fly   975 SKCYVATQGPLPNTIFEFWLMIYQNTQRYIRRCVDGGSSSSPHVDREQILQQYFQKIVMLTNFTE 1039
            .:.::|||||:.||:.:||.|::|..      |                     ..|||:|...|
Zfish   441 ERAFIATQGPMINTVNDFWQMVWQED------C---------------------PVIVMITKLKE 478

  Fly  1040 ANRQKCAVYFPIELNEIFAVAAKCEVFQLSAAARDYFDRYLTPTFVPDTVVASSDAIDYEISGRH 1104
            .| :||.:|:|    |...:..|.||
Zfish   479 KN-EKCVLYWP----EKRGIYGKVEV--------------------------------------- 499

  Fly  1105 IGVESVKVTLEGDLLEALPAQGSFFLIKNVGIVRRNGYSVRKLVLLYCIRVPQSASYHLQKIYCY 1169
             .|.:||             :...::|:.:.:  :||...||:                     .
Zfish   500 -SVNNVK-------------ECDHYIIRTLNL--KNGGQSRKV---------------------Q 527

  Fly  1170 HYWYPDWPDHHSPRDINTLLDTCLHVLNLGKCESEFDIYDDTRSERNAHLAAQRLEIYQQDIFNA 1234
            ||||..||||.:|.....||                .:.:|...:|..              :.:
Zfish   528 HYWYTSWPDHKTPESAGPLL----------------QLVNDVEEDRKG--------------WTS 562

  Fly  1235 VQPLPVIHCSAGIGRTGCFTAILNAVRQLRQSLAYSLTGMLTKSLTSSSTEEYHNPTDSDSSFTC 1299
            ..|: |:||||||||||||.|.....|||      .|.|:
Zfish   563 SGPV-VVHCSAGIGRTGCFMATTIGCRQL------GLEGL------------------------- 595

  Fly  1300 NTIRHISHILDHRDAEAVKTPPSFDRLPKMPDIFVDVLGIVCNLRLQRGGMVQNSEQYELIHRAI 1364
                                              ||||||||.||..||||:|..||||.:|.|:
Zfish   596 ----------------------------------VDVLGIVCQLRTDRGGMIQTEEQYEFVHHAL 626

  Fly  1365 CLY 1367
            .||
Zfish   627 SLY 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	Y_phosphatase	916..1364	CDD:278528	113/449 (25%)
PTP-ER	NP_726092.1	PTPc	917..1364	CDD:238006	113/448 (25%)
ptprr	XP_021330980.1	PTPc	400..626	CDD:238006	113/447 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3586
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.050