DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTP-ER and ptpn23a

DIOPT Version :9

Sequence 1:	NP_726092.1	Gene:	PTP-ER / 37461	FlyBaseID:	FBgn0016641	Length:	1377	Species:	Drosophila melanogaster
Sequence 2:	XP_005158252.1	Gene:	ptpn23a / 100007322	ZFINID:	ZDB-GENE-100921-24	Length:	2003	Species:	Danio rerio

Alignment Length:	1364	Identity:	255/1364 - (18%)
Similarity:	405/1364 - (29%)	Gaps:	571/1364 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 IEYPYPQTPRPT----------HAAPSDTTPLEAGEDAESNKSTPYFTPLEYLQTSFEFPSPTVE 68
            ::..:||.|.|.          |..||...|   |....:.:  |..|.::.:||.....|| ..
Zfish   835 MQQQFPQMPNPQVLPPPPVSGYHPQPSQNQP---GPSVTAVR--PSTTTVDSIQTPITSYSP-AS 893

  Fly    69 VGGGVPGFPEHEDQEEEVFTPRQFTITSPHPAAHVH--------HPSSSQSPTLGRKFKRLSQYD 125
            ....:|...:|:               .|||.:.|:        |....|.|.:     .:||..
Zfish   894 AQAVMPSPGQHQ---------------VPHPISSVYATPPQMAPHVQYMQQPGV-----PMSQPP 938

  Fly   126 RRSCSPH------INTSSGEERVSGRGIDKENTMPKGGSVDQDLENSLYLSKSEHNSPTI----- 179
            :...:||      :....|.:. ..:....:..:|....:.:.|..|   ..|:|.:|..
Zfish   939 QAMPAPHPQPQPQVFAQQGGQN-QPQPFYPQAVLPSQQQMPRPLTGS---QPSQHTTPQFPQYIR 999

  Fly   180 --------------LFKDESSTTPGLEA-SRLSYSPKL-LSSINNLNVSGSPLNIINSAGYKNGN 228
                          .|:...|..|..:. ..:|:.||. |..:|.:|    |..:.:|     |.
Zfish  1000 QPGPPNFQQPQMQGQFRAPPSHAPPHQGYPPVSFVPKAPLPQVNTIN----PGQMSHS-----GV 1055

  Fly   229 FFRFPEIDHVVQDAPMDTVCLEEATRRDRSPALAE-----PPEQQQQKSEGRKNRKNKNNLTIRI 288
            ..:.|...|.|....|              |.||.     ||..|...|....:.. :.||.|..
Zfish  1056 SPQMPLSSHPVPPVSM--------------PHLAHVNQHIPPSSQPVPSMSMPHLA-RVNLQIAP 1105

  Fly   289 TDVPIKNSSQP---------SPLPKPKTPTIKSTKEKARSLDSAANESELSIVVHNITESHGSCD 344
            :..|:.::|.|         .|..:|:.|.:                :.||...|.
Zfish  1106 SSQPVSSASMPHLAHVSQQIPPASQPQPPPV----------------NHLSHPPHR--------- 1145

  Fly   345 DMETGQSQPSTSVIHHHL----HLQQPAS----------AIHSTSLSRLDSHLSLANQRRTPRRK 395
                 |..||:    |||    |:|.||:          .:|::|......|..:.:..:.|
Zfish  1146 -----QIHPSS----HHLGPTPHMQIPAAPTQMPPPQQPQMHASSTHMSPPHPQMPSVSQPP--- 1198

  Fly   396 SPGINTTDWLMYHR--KQNPYQVQPTHCSSTTQ-----SSLDSDASLTPSLGDFELKSACSVDGG 453
             |....:..:..|:  :|.||...|...:...|     .||.|...:.|:
Zfish  1199 -PHCPQSHIIPAHQPNQQPPYPAVPMQATVPIQPQAPHGSLPSQVQIHPN--------------- 1247

  Fly   454 SKFGIGASLAPRSAHKHNQLLHSSSTNLKTLPECL-----TLVEFS---SSGGGPKESPFKQKSM 510
                   :.:....|.|.|::..|..  ..||..:     |:...|   |..||....|.:.
Zfish  1248 -------TPSQHQNHPHPQIIPQSCP--PALPHNMYKPQPTITPISAPMSFPGGVPMVPHQS--- 1300

  Fly   511 DLPMPTLQAKTTVSTSSMNLLQRRGSNHSLTLNLHSSCGNLMNSGLSHSNYSLGSILNSKSSCNL 575
               :|:||.::...:|...:.|:......::..: ...||:....:.|            .....
Zfish  1301 ---VPSLQPQSQPPSSKPLVPQQLPPGGPISYAV-PQVGNIPPGAMQH------------PVATA 1349

  Fly   576 DAGTASQI----RADQLPQSHLLGSSQGSRQGLFRRRGSNHSITLKTGHTTTSCGDLNSMQQLQQ 636
            ..|..|.|    .|...||.|:|.|.
Zfish  1350 SPGPQSMIPPSSGAPGAPQPHVLPSP--------------------------------------- 1375

  Fly   637 QQAMLSAEKYNRLNMRTNSTGSGSGSGSNVPTPKRGLLERRGSNQSLTLNMGSILGGAAGTEIQM 701
                                 :.|.|.|..| |..|:..:|.| .:||     .:||||
Zfish  1376 ---------------------APSPSPSPGP-PSLGMTTQRPS-PALT-----PVGGAA------ 1406

  Fly   702 TDIVQPKVTVCSCAAANQAPH------QRKFFSTENLNSSKANSQKFFGQVCFGSASD----LQP 756
                .|:.:|...|.....|.      ||:..||::|.||...||       .|...|    |.|
Zfish  1407 ----MPQSSVQGPAPTGTMPQPDSTLFQRQNSSTDDLLSSSPESQ-------HGGTKDTACVLLP 1460

  Fly   757 ---NPQQDSVREDQAIGATCTCAGTVRNIMTRPL-SPQTTSEEFKIYLASIQMLQSASNPLNQFD 817
               :||::..|:.         |..||.|...|. :|:..|:              .|..|.:|
Zfish  1461 TKADPQEEHHRKK---------AEGVRLIQGDPYQAPERVSK--------------LSAQLERF- 1501

  Fly   818 LIRLNYVFDHSYQTNRNIIEQPPVLGSNARDVETPTDMVPPSSEDSELLASYQTVVSRMAQPIPE 882
                                     .|..:.:|.||.    ....|||.|.::           |
Zfish  1502 -------------------------RSTVQSLERPTG----EGGLSELDAQWK-----------E 1526

  Fly   883 LKENEQKRIFRDLHKEFWDLPLNHQEKPMVFGSQT-KNRYKTILPNENSRVLLESESSELTSLLG 946
            |:|.::|.              ..|....:....| |||::.::|.:.:||:|.|...:
Zfish  1527 LQEQQEKD--------------TRQLSIAIARCYTMKNRHQDVMPYDCNRVVLHSGKDD------ 1571

  Fly   947 EIKRTSSVTASEDLPYINANYIKGPDYVSKC--YVATQGPLPNTIFEFWLMIYQNTQRYIRRCVD 1009
                           ||||::.:  |....|  .:|||.||..|..:||||:|
Zfish  1572 ---------------YINASFTE--DLSPYCPRLIATQAPLTGTAADFWLMVY------------ 1607

  Fly  1010 GGSSSSPHVDREQILQQYFQKIVMLTNFTEANRQKCAVYFPIELNEIFAVAAKCEVFQLSAAARD 1074
                           :|....||||.:..|..:||...|||.|..:..|
Zfish  1608 ---------------EQKVSVIVMLVSEQELEKQKVLRYFPSERGQQLA---------------- 1641

  Fly  1075 YFDRYLTPTFVPDTVVASSDAIDYEISGRHIGVESVKVTLEGDLLEALPAQGS--FFLIKNVGIV 1137
                                                    :|.:...|..|.|  ..:.:.:|:.
Zfish  1642 ----------------------------------------QGPITLTLTTQKSTPTHIERMIGLQ 1666

  Fly  1138 RRNGYSVRKLVLLYCIRVPQSASYHLQKIYCYHYWYPDWPDHHSPRDINTLLDTCLHVLNLGKCE 1202
            .|: .|:|:.|:            |||        :..||:                   ||..|
Zfish  1667 YRD-QSLRRTVV------------HLQ--------FTSWPE-------------------LGLPE 1691

  Fly  1203 SEFDIYDDTRSERNAHLAAQRLEIYQQDIFNAVQPL---PVIHCSAGIGRTGCFTAILNAVRQL 1263
            |:.::....: |.:.|...||             ||   .|:|||:|:||||.|..:..|::::
Zfish  1692 SKSNLIRFIQ-EVHGHYLLQR-------------PLHTPVVVHCSSGVGRTGAFCLLYAALQEI 1741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTP-ER	NP_726092.1	Y_phosphatase	916..1364	CDD:278528	74/356 (21%)
PTP-ER	NP_726092.1	PTPc	917..1364	CDD:238006	74/355 (21%)
ptpn23a	XP_005158252.1	BRO1_HD-PTP_like	2..357	CDD:185762
		V_HD-PTP_like	362..698	CDD:185747
		ALIX_LYPXL_bnd	416..701	CDD:290660
		Y_phosphatase	1548..1780	CDD:278528	73/354 (21%)
		PTPc	1549..1779	CDD:238006	73/353 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900